The effect of a single oral dose of L-arginine on quadriceps strength in smokers and non-smokers: a non-randomized clinical trial
Smoking is a major risk factor for the development of chronic obstructive pulmonary disease (COPD), which is thought to be caused by smoking in even 8 out of 10 cases. One of the first clinical signs in patients with COPD is reduced physical ability, which is usually attributed to reduced lung fu...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2024-01-01
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| Series: | Acta Clinica Croatica |
| Subjects: | |
| Online Access: | https://hrcak.srce.hr/file/474020 |
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| Summary: | Smoking is a major risk factor for the development of chronic obstructive
pulmonary disease (COPD), which is thought to be caused by smoking in even 8 out of 10 cases. One
of the first clinical signs in patients with COPD is reduced physical ability, which is usually attributed
to reduced lung function, although a significant role is played by a disorder of the musculoskeletal
system. Th e aim of the study was to examine differences in fitness and locomotor status between
smokers and non-smokers, as well as the effect of oral administration of L-arginine on the strength
of the quadriceps depending on smoking status. The study included 164 subjects, 84 non-smokers and
81 smokers not diagnosed with COPD. All subjects completed CAT and IPAQ questionnaires, and
performed spirometry, 6-minute walking test and quadriceps strength testing without therapy and
after oral administration of 500 mg L-arginine. Th e results showed that the increase in quadriceps
strength after oral administration of L-arginine was not dependent on smoking status but was more
pronounced in smokers who started smoking at an earlier age and who smoked more cigarettes, as
well as a generally higher physical activity of non-smokers. These results could become relevant for
recognizing the development of skeletal musculature hypotonus and hypotrophy in smokers who are
prone to develop COPD. |
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| ISSN: | 0353-9466 1333-9451 |