Immunological Aspects of Acute and Recurrent Herpes Simplex Keratitis
Herpes simplex keratitis (HSK) belongs to the major causes of visual morbidity worldwide and available methods of treatment remain unsatisfactory. Primary infection occurs usually early in life and is often asymptomatic. Chronic visual impairment and visual loss are caused by corneal scaring, thinni...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/513560 |
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| _version_ | 1849691964345155584 |
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| author | Jacek Rolinski Iwona Hus |
| author_facet | Jacek Rolinski Iwona Hus |
| author_sort | Jacek Rolinski |
| collection | DOAJ |
| description | Herpes simplex keratitis (HSK) belongs to the major causes of visual morbidity worldwide and available methods of treatment remain unsatisfactory. Primary infection occurs usually early in life and is often asymptomatic. Chronic visual impairment and visual loss are caused by corneal scaring, thinning, and vascularization connected with recurrent HSV infections. The pathogenesis of herpetic keratitis is complex and is still not fully understood. According to the current knowledge, corneal scarring and vascularization are the result of chronic inflammatory reaction against HSV antigens. In this review we discuss the role of innate and adaptive immunities in acute and recurrent HSV ocular infection and present the potential future targets for novel therapeutical options based on immune interventions. |
| format | Article |
| id | doaj-art-b444c3c9ca1647f8bd5bd3c1f72b7e03 |
| institution | DOAJ |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-b444c3c9ca1647f8bd5bd3c1f72b7e032025-08-20T03:20:51ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/513560513560Immunological Aspects of Acute and Recurrent Herpes Simplex KeratitisJacek Rolinski0Iwona Hus1Chair and Department of Clinical Immunology, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, PolandDepartment of Clinical Transplantology, Medical University of Lublin, Staszica 11, 20-081 Lublin, PolandHerpes simplex keratitis (HSK) belongs to the major causes of visual morbidity worldwide and available methods of treatment remain unsatisfactory. Primary infection occurs usually early in life and is often asymptomatic. Chronic visual impairment and visual loss are caused by corneal scaring, thinning, and vascularization connected with recurrent HSV infections. The pathogenesis of herpetic keratitis is complex and is still not fully understood. According to the current knowledge, corneal scarring and vascularization are the result of chronic inflammatory reaction against HSV antigens. In this review we discuss the role of innate and adaptive immunities in acute and recurrent HSV ocular infection and present the potential future targets for novel therapeutical options based on immune interventions.http://dx.doi.org/10.1155/2014/513560 |
| spellingShingle | Jacek Rolinski Iwona Hus Immunological Aspects of Acute and Recurrent Herpes Simplex Keratitis Journal of Immunology Research |
| title | Immunological Aspects of Acute and Recurrent Herpes Simplex Keratitis |
| title_full | Immunological Aspects of Acute and Recurrent Herpes Simplex Keratitis |
| title_fullStr | Immunological Aspects of Acute and Recurrent Herpes Simplex Keratitis |
| title_full_unstemmed | Immunological Aspects of Acute and Recurrent Herpes Simplex Keratitis |
| title_short | Immunological Aspects of Acute and Recurrent Herpes Simplex Keratitis |
| title_sort | immunological aspects of acute and recurrent herpes simplex keratitis |
| url | http://dx.doi.org/10.1155/2014/513560 |
| work_keys_str_mv | AT jacekrolinski immunologicalaspectsofacuteandrecurrentherpessimplexkeratitis AT iwonahus immunologicalaspectsofacuteandrecurrentherpessimplexkeratitis |