Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting
Multiple-unit-type oral floating hollow microspheres of 5-fluorouracil (5-Fu) were developed using modified solvent evaporation technique to prolong gastric residence time, to target stomach cancer, and to increase drug bioavailability. The prepared microspheres were characterized for micromeritic p...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/705259 |
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| author | Peeyush Bhardwaj Deepti Chaurasia Ranjit Singh Anoop Swarup |
| author_facet | Peeyush Bhardwaj Deepti Chaurasia Ranjit Singh Anoop Swarup |
| author_sort | Peeyush Bhardwaj |
| collection | DOAJ |
| description | Multiple-unit-type oral floating hollow microspheres of 5-fluorouracil (5-Fu) were developed using modified solvent evaporation technique to prolong gastric residence time, to target stomach cancer, and to increase drug bioavailability. The prepared microspheres were characterized for micromeritic properties, floating behavior, entrapment efficiency, and scanning electron microscopy (SEM). The in vitro drug release and floating behavior were studied in simulated gastric fluid (SGF) at pH 1.2. The yield of microspheres was obtained up to 84.46±6.47%. Microspheres showed passable flow properties. Based on optical microscopy, particle size was found to be ranging from 158.65±12.02 to 198.67±17.45 μm. SEM confirmed spherical size, perforated smooth surface, and a hollow cavity inside the microspheres. Different kinetic models for drug release were also applied on selected batches. |
| format | Article |
| id | doaj-art-b440d358f8bd4bc482c43b0b32fd46e0 |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-b440d358f8bd4bc482c43b0b32fd46e02025-08-20T02:23:13ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/705259705259Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach TargetingPeeyush Bhardwaj0Deepti Chaurasia1Ranjit Singh2Anoop Swarup3Institute of Pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, IndiaNKBR College of Pharmacy & Research Centre, Meerut, Uttar Pradesh, IndiaGovernment College of Pharmacy, Rohru, Shimla, Himachal Pradesh, IndiaJagran Lakecity University, Bhopal, Madhya Pradesh, IndiaMultiple-unit-type oral floating hollow microspheres of 5-fluorouracil (5-Fu) were developed using modified solvent evaporation technique to prolong gastric residence time, to target stomach cancer, and to increase drug bioavailability. The prepared microspheres were characterized for micromeritic properties, floating behavior, entrapment efficiency, and scanning electron microscopy (SEM). The in vitro drug release and floating behavior were studied in simulated gastric fluid (SGF) at pH 1.2. The yield of microspheres was obtained up to 84.46±6.47%. Microspheres showed passable flow properties. Based on optical microscopy, particle size was found to be ranging from 158.65±12.02 to 198.67±17.45 μm. SEM confirmed spherical size, perforated smooth surface, and a hollow cavity inside the microspheres. Different kinetic models for drug release were also applied on selected batches.http://dx.doi.org/10.1155/2014/705259 |
| spellingShingle | Peeyush Bhardwaj Deepti Chaurasia Ranjit Singh Anoop Swarup Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting The Scientific World Journal |
| title | Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting |
| title_full | Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting |
| title_fullStr | Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting |
| title_full_unstemmed | Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting |
| title_short | Development and Characterization of Novel Site Specific Hollow Floating Microspheres Bearing 5-Fu for Stomach Targeting |
| title_sort | development and characterization of novel site specific hollow floating microspheres bearing 5 fu for stomach targeting |
| url | http://dx.doi.org/10.1155/2014/705259 |
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