Use of Modified Glucose-Insulin-Potassium Mixture in Cardiosurgical Patients
The investigation was undertaken to study the hemodynamic and metabolic effects of modified (with elevated glucose and insulin levels) glucose-insulin-potassium (GIP) mixture in the correction of acute heart failure in cardiosurgical patients. After infusion of the modified GIP mixture (0.9 g of glu...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2006-12-01
|
| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/1379 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850041211460517888 |
|---|---|
| author | V. N. Poptsov Ye. V. Morozyuk B. Yu. Bogomolov |
| author_facet | V. N. Poptsov Ye. V. Morozyuk B. Yu. Bogomolov |
| author_sort | V. N. Poptsov |
| collection | DOAJ |
| description | The investigation was undertaken to study the hemodynamic and metabolic effects of modified (with elevated glucose and insulin levels) glucose-insulin-potassium (GIP) mixture in the correction of acute heart failure in cardiosurgical patients. After infusion of the modified GIP mixture (0.9 g of glucose per kg body weight and 3.75 units of insulin per g glucose), in 15 patients (12 males and 3 females) aged 35 to 72 (54±5) years the increase (p<0.05) in cardiac index and stroke volume index was 21% with simultaneous 20 and 17% decreases in pulmonary wedge pressure and mean pulmonary pressure, respectively (p<0.05). The duration of infusion was 5 hours. A steady-state improvement of cardiac pump function and metabolic parameters could reduce the dosage of cardiotonic drugs 12 hours after administration of the modified GIP mixture. During and after administration of the mixture, the blood levels of glucose and potassium were substantially unchanged. In the study group, all the patients survived. The duration of a resuscitative period was 2.4±0.2 days. With the management protocol used, infusion of the modified GIP mixture was favorable to the steady-state improvement of cardiac pump function without carbohydrate and electrolyte homeostatic impairments.acute heart failure; glucose-insulin-potassium mixture |
| format | Article |
| id | doaj-art-b43fb31a7b804a59894f43d4872cfc0b |
| institution | DOAJ |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2006-12-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-b43fb31a7b804a59894f43d4872cfc0b2025-08-20T02:55:49ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102006-12-012616316610.15360/1813-9779-2006-6-163-1661379Use of Modified Glucose-Insulin-Potassium Mixture in Cardiosurgical PatientsV. N. Poptsov0Ye. V. Morozyuk1B. Yu. Bogomolov2Research Institute of Transplantology and Artificial Organs, Russian Ministry of Health, MoscowResearch Institute of Transplantology and Artificial Organs, Russian Ministry of Health, MoscowResearch Institute of Transplantology and Artificial Organs, Russian Ministry of Health, MoscowThe investigation was undertaken to study the hemodynamic and metabolic effects of modified (with elevated glucose and insulin levels) glucose-insulin-potassium (GIP) mixture in the correction of acute heart failure in cardiosurgical patients. After infusion of the modified GIP mixture (0.9 g of glucose per kg body weight and 3.75 units of insulin per g glucose), in 15 patients (12 males and 3 females) aged 35 to 72 (54±5) years the increase (p<0.05) in cardiac index and stroke volume index was 21% with simultaneous 20 and 17% decreases in pulmonary wedge pressure and mean pulmonary pressure, respectively (p<0.05). The duration of infusion was 5 hours. A steady-state improvement of cardiac pump function and metabolic parameters could reduce the dosage of cardiotonic drugs 12 hours after administration of the modified GIP mixture. During and after administration of the mixture, the blood levels of glucose and potassium were substantially unchanged. In the study group, all the patients survived. The duration of a resuscitative period was 2.4±0.2 days. With the management protocol used, infusion of the modified GIP mixture was favorable to the steady-state improvement of cardiac pump function without carbohydrate and electrolyte homeostatic impairments.acute heart failure; glucose-insulin-potassium mixturehttps://www.reanimatology.com/rmt/article/view/1379acute heart failureglucose-insulin-potassium mixture |
| spellingShingle | V. N. Poptsov Ye. V. Morozyuk B. Yu. Bogomolov Use of Modified Glucose-Insulin-Potassium Mixture in Cardiosurgical Patients Общая реаниматология acute heart failure glucose-insulin-potassium mixture |
| title | Use of Modified Glucose-Insulin-Potassium Mixture in Cardiosurgical Patients |
| title_full | Use of Modified Glucose-Insulin-Potassium Mixture in Cardiosurgical Patients |
| title_fullStr | Use of Modified Glucose-Insulin-Potassium Mixture in Cardiosurgical Patients |
| title_full_unstemmed | Use of Modified Glucose-Insulin-Potassium Mixture in Cardiosurgical Patients |
| title_short | Use of Modified Glucose-Insulin-Potassium Mixture in Cardiosurgical Patients |
| title_sort | use of modified glucose insulin potassium mixture in cardiosurgical patients |
| topic | acute heart failure glucose-insulin-potassium mixture |
| url | https://www.reanimatology.com/rmt/article/view/1379 |
| work_keys_str_mv | AT vnpoptsov useofmodifiedglucoseinsulinpotassiummixtureincardiosurgicalpatients AT yevmorozyuk useofmodifiedglucoseinsulinpotassiummixtureincardiosurgicalpatients AT byubogomolov useofmodifiedglucoseinsulinpotassiummixtureincardiosurgicalpatients |