Analysis of Wilms Tumour Epidemiology, Clinicopathological Features and Treatment Outcomes in 84 Moroccan Patients
ABSTRACT Background Wilms tumour (WT), the second most reported childhood cancer in Morocco, is a malignant kidney tumour that affects children under 15 years old. Prognosis has improved with the adoption of multimodal treatment. However, data on WT in Morocco remain limited. Aims This study aims to...
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Wiley
2024-11-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.2158 |
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| author | Sara Benlhachemi Mohammed Khattab Kenza Hattoufi Redouane Abouqal Saber Boutayeb Elmostafa El Fahime |
| author_facet | Sara Benlhachemi Mohammed Khattab Kenza Hattoufi Redouane Abouqal Saber Boutayeb Elmostafa El Fahime |
| author_sort | Sara Benlhachemi |
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| description | ABSTRACT Background Wilms tumour (WT), the second most reported childhood cancer in Morocco, is a malignant kidney tumour that affects children under 15 years old. Prognosis has improved with the adoption of multimodal treatment. However, data on WT in Morocco remain limited. Aims This study aims to comprehensively describe and analyse the epidemiological, clinicopathological features and treatment outcomes of WT in Moroccan patients, including treatment response and recurrence rates. Methods and Results A retrospective study involved 84 children under 15 years with WT, treated according to the SIOP protocol and followed at the Paediatric Haematology and Oncology Centre at Children's hospital of Rabat, between January 2014 and February 2018. The median age of participants was 36 months, with a male/female sex ratio of 0.79. Abdominal mass was the primary concern in 55 cases (66%). Five patients (6%) had bilateral WT. Metastatic WT occurred in 21 cases (25%). Stage III was predominant in 33 cases (43%). Twenty cases (26%) had high‐risk WT, and IVC tumour thrombus was observed in 12 cases (14%). WT histotype correlated significantly with both sex and tumour localisation (p values of 0.040 and 0.013, respectively). Age correlated significantly with WT extension, overall stage and SIOP histology risk grades (p values of 0.003, 0.003 and 0.045, respectively). Overall stage was statistically related to the occurrence of IVC tumour thrombus (p = 0.002). Over a 5‐year span post‐nephrectomy, complete remission was achieved in 63 patients (75%), partial remission in one patient (1%), while 19 patients (23%) died and one patient (1%) relapsed. Conclusion These findings are encouraging for a developing country. However, the elevated rates of Stages III and IVC thrombus in this series are still high, primarily attributed to delays in diagnosis and treatment and the limited number of paediatric haematology and oncology units at the time of the study. Nevertheless, further multicentric research is warranted to enrich Moroccan data and establish a national register for WT cases. |
| format | Article |
| id | doaj-art-b4354e78e64b4e73a899c147f16aba03 |
| institution | OA Journals |
| issn | 2573-8348 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
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| series | Cancer Reports |
| spelling | doaj-art-b4354e78e64b4e73a899c147f16aba032025-08-20T02:05:28ZengWileyCancer Reports2573-83482024-11-01711n/an/a10.1002/cnr2.2158Analysis of Wilms Tumour Epidemiology, Clinicopathological Features and Treatment Outcomes in 84 Moroccan PatientsSara Benlhachemi0Mohammed Khattab1Kenza Hattoufi2Redouane Abouqal3Saber Boutayeb4Elmostafa El Fahime5Neuroscience and Neurogenetics Research Team (ERNN), Faculty of Medicine and Pharmacy Mohammed V University Rabat MoroccoDepartment of Paediatric Haematology and Oncology Abulcasis International University of Health Sciences Rabat MoroccoDepartment of Neonatology and Nutrition University Hospital Centre IBN SINA Rabat MoroccoBiostatistics Laboratory, Clinical Epidemiology Research, Faculty of Medicine and Pharmacy Mohammed V University Rabat MoroccoMedical Oncology Department National Institute of Oncology, Mohammed V University Rabat MoroccoNeuroscience and Neurogenetics Research Team (ERNN), Faculty of Medicine and Pharmacy Mohammed V University Rabat MoroccoABSTRACT Background Wilms tumour (WT), the second most reported childhood cancer in Morocco, is a malignant kidney tumour that affects children under 15 years old. Prognosis has improved with the adoption of multimodal treatment. However, data on WT in Morocco remain limited. Aims This study aims to comprehensively describe and analyse the epidemiological, clinicopathological features and treatment outcomes of WT in Moroccan patients, including treatment response and recurrence rates. Methods and Results A retrospective study involved 84 children under 15 years with WT, treated according to the SIOP protocol and followed at the Paediatric Haematology and Oncology Centre at Children's hospital of Rabat, between January 2014 and February 2018. The median age of participants was 36 months, with a male/female sex ratio of 0.79. Abdominal mass was the primary concern in 55 cases (66%). Five patients (6%) had bilateral WT. Metastatic WT occurred in 21 cases (25%). Stage III was predominant in 33 cases (43%). Twenty cases (26%) had high‐risk WT, and IVC tumour thrombus was observed in 12 cases (14%). WT histotype correlated significantly with both sex and tumour localisation (p values of 0.040 and 0.013, respectively). Age correlated significantly with WT extension, overall stage and SIOP histology risk grades (p values of 0.003, 0.003 and 0.045, respectively). Overall stage was statistically related to the occurrence of IVC tumour thrombus (p = 0.002). Over a 5‐year span post‐nephrectomy, complete remission was achieved in 63 patients (75%), partial remission in one patient (1%), while 19 patients (23%) died and one patient (1%) relapsed. Conclusion These findings are encouraging for a developing country. However, the elevated rates of Stages III and IVC thrombus in this series are still high, primarily attributed to delays in diagnosis and treatment and the limited number of paediatric haematology and oncology units at the time of the study. Nevertheless, further multicentric research is warranted to enrich Moroccan data and establish a national register for WT cases.https://doi.org/10.1002/cnr2.2158clinicopathologyhistopathologySIOP protocoltreatmentWilms tumour |
| spellingShingle | Sara Benlhachemi Mohammed Khattab Kenza Hattoufi Redouane Abouqal Saber Boutayeb Elmostafa El Fahime Analysis of Wilms Tumour Epidemiology, Clinicopathological Features and Treatment Outcomes in 84 Moroccan Patients Cancer Reports clinicopathology histopathology SIOP protocol treatment Wilms tumour |
| title | Analysis of Wilms Tumour Epidemiology, Clinicopathological Features and Treatment Outcomes in 84 Moroccan Patients |
| title_full | Analysis of Wilms Tumour Epidemiology, Clinicopathological Features and Treatment Outcomes in 84 Moroccan Patients |
| title_fullStr | Analysis of Wilms Tumour Epidemiology, Clinicopathological Features and Treatment Outcomes in 84 Moroccan Patients |
| title_full_unstemmed | Analysis of Wilms Tumour Epidemiology, Clinicopathological Features and Treatment Outcomes in 84 Moroccan Patients |
| title_short | Analysis of Wilms Tumour Epidemiology, Clinicopathological Features and Treatment Outcomes in 84 Moroccan Patients |
| title_sort | analysis of wilms tumour epidemiology clinicopathological features and treatment outcomes in 84 moroccan patients |
| topic | clinicopathology histopathology SIOP protocol treatment Wilms tumour |
| url | https://doi.org/10.1002/cnr2.2158 |
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