Pregnancy and Neonatal Outcomes in SARS-CoV-2 Infection: A Systematic Review
With the emergence of SARS-CoV-2 and its rapid spread, concerns regarding its effects on pregnancy outcomes have been growing. We reviewed 245 pregnancies complicated by maternal SARS-CoV-2 infection across 48 studies listed on PubMed and MedRxiv. The most common clinical presentations were fever (5...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2020/4592450 |
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| author | Reem S. Chamseddine Farah Wahbeh Frank Chervenak Laurent J. Salomon Baderledeen Ahmed Arash Rafii |
| author_facet | Reem S. Chamseddine Farah Wahbeh Frank Chervenak Laurent J. Salomon Baderledeen Ahmed Arash Rafii |
| author_sort | Reem S. Chamseddine |
| collection | DOAJ |
| description | With the emergence of SARS-CoV-2 and its rapid spread, concerns regarding its effects on pregnancy outcomes have been growing. We reviewed 245 pregnancies complicated by maternal SARS-CoV-2 infection across 48 studies listed on PubMed and MedRxiv. The most common clinical presentations were fever (55.9%), cough (36.3%), fatigue (11.4%), and dyspnea (12.7%). Only 4.1% of patients developed respiratory distress. Of all patients, 89.0% delivered via cesarean section (n=201), with a 33.3% rate of gestational complications, a 35.3% rate of preterm delivery, and a concerning 2.5% rate of stillbirth delivery or neonatal death. Among those tested, 6.45% of newborns were reported positive for SARS-CoV-2 infection. Relative to known viral infections, the prognosis for pregnant women with SARS-CoV-2 is good, even in the absence of specific antiviral treatment. However, neonates and acute patients, especially those with gestational or preexisting comorbidities, must be actively managed to prevent the severe outcomes being increasingly reported in the literature. |
| format | Article |
| id | doaj-art-b4331e83d5b04587ab0a2295b744c85d |
| institution | OA Journals |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-b4331e83d5b04587ab0a2295b744c85d2025-08-20T02:23:13ZengWileyJournal of Pregnancy2090-27272090-27352020-01-01202010.1155/2020/45924504592450Pregnancy and Neonatal Outcomes in SARS-CoV-2 Infection: A Systematic ReviewReem S. Chamseddine0Farah Wahbeh1Frank Chervenak2Laurent J. Salomon3Baderledeen Ahmed4Arash Rafii5Genetic Intelligence Laboratory, Weill Cornell Medicine-Qatar, Doha, QatarGenetic Intelligence Laboratory, Weill Cornell Medicine-Qatar, Doha, QatarDepartment of Obstetrics and Gynecology, Zucker School of Medicine at Hofstra/Northwell-Lenox Hill Hospital, New York, USAMaternité, Médecine, Chirurgie et Imagerie Fœtales, Hôpital Universitaire Necker Enfants Malades, Université de Paris and EA FETUS, Affiliate of Institute Imagine, Paris, FranceFetal Maternal Center, Doha, QatarGenetic Intelligence Laboratory, Weill Cornell Medicine-Qatar, Doha, QatarWith the emergence of SARS-CoV-2 and its rapid spread, concerns regarding its effects on pregnancy outcomes have been growing. We reviewed 245 pregnancies complicated by maternal SARS-CoV-2 infection across 48 studies listed on PubMed and MedRxiv. The most common clinical presentations were fever (55.9%), cough (36.3%), fatigue (11.4%), and dyspnea (12.7%). Only 4.1% of patients developed respiratory distress. Of all patients, 89.0% delivered via cesarean section (n=201), with a 33.3% rate of gestational complications, a 35.3% rate of preterm delivery, and a concerning 2.5% rate of stillbirth delivery or neonatal death. Among those tested, 6.45% of newborns were reported positive for SARS-CoV-2 infection. Relative to known viral infections, the prognosis for pregnant women with SARS-CoV-2 is good, even in the absence of specific antiviral treatment. However, neonates and acute patients, especially those with gestational or preexisting comorbidities, must be actively managed to prevent the severe outcomes being increasingly reported in the literature.http://dx.doi.org/10.1155/2020/4592450 |
| spellingShingle | Reem S. Chamseddine Farah Wahbeh Frank Chervenak Laurent J. Salomon Baderledeen Ahmed Arash Rafii Pregnancy and Neonatal Outcomes in SARS-CoV-2 Infection: A Systematic Review Journal of Pregnancy |
| title | Pregnancy and Neonatal Outcomes in SARS-CoV-2 Infection: A Systematic Review |
| title_full | Pregnancy and Neonatal Outcomes in SARS-CoV-2 Infection: A Systematic Review |
| title_fullStr | Pregnancy and Neonatal Outcomes in SARS-CoV-2 Infection: A Systematic Review |
| title_full_unstemmed | Pregnancy and Neonatal Outcomes in SARS-CoV-2 Infection: A Systematic Review |
| title_short | Pregnancy and Neonatal Outcomes in SARS-CoV-2 Infection: A Systematic Review |
| title_sort | pregnancy and neonatal outcomes in sars cov 2 infection a systematic review |
| url | http://dx.doi.org/10.1155/2020/4592450 |
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