Maternal Serum Fractalkine Concentrations in Pregnancies Complicated by Fetal Growth Restriction
OBJECTIVE: Fractalkine is a newly discovered chemokine that is expressed in placental tissue during pregnancy and is subsequently shed into the maternal serum. Although there are a few studies examining the relationship between fractalkine and preeclampsia, its role in isolated fetal growth restric...
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Medical Network
2023-08-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1342 |
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| author | Ecem Berfun Toprak Sager Ibrahim Kale Hakan Sager Aysegul Ozel Murat Muhcu |
| author_facet | Ecem Berfun Toprak Sager Ibrahim Kale Hakan Sager Aysegul Ozel Murat Muhcu |
| author_sort | Ecem Berfun Toprak Sager |
| collection | DOAJ |
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OBJECTIVE: Fractalkine is a newly discovered chemokine that is expressed in placental tissue during pregnancy and is subsequently shed into the maternal serum. Although there are a few studies examining the relationship between fractalkine and preeclampsia, its role in isolated fetal growth restriction has not been investigated yet. In this study, we aimed to investigate the relationship between isolated fetal growth restriction and maternal serum fractalkine concentrations.
STUDY DESIGN: This cross-sectional study was conducted on 86 pregnant women, 25 of whom were diagnosed with fetal growth restriction in the third trimester, 23 were small for gestational age, and 38 were healthy controls. These three groups were compared in terms of maternal serum fractalkine concentrations.
RESULTS: While the highest mean maternal serum fractalkine concentration was found in the small for gestational age group at 23.31 ng/mL, it was determined as 18.06 ng/mL in the fetal growth restriction group and 16.03 ng/mL in the control group. We did not find a statistical difference between the groups in terms of fractalkine concentrations (p=0.258). When the patients with fetal growth restriction and small for gestational age were evaluated as a single group and compared with the control group, the mean fractalkine concentration in the fetal growth restriction+small for gestational age group was higher than the control group, but this difference was not statistically significant (p=0.214).
CONCLUSION: Maternal serum fractalkine concentration was higher in both fetal growth restriction and small for gestational age groups compared to healthy controls, but this difference was not statistically significant. The role of the fractalkine molecule in the development of fetal growth restriction remains to be clarified in future studies with larger series.
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| format | Article |
| id | doaj-art-b4291bace6394245adfb065a8b27a777 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-b4291bace6394245adfb065a8b27a7772025-02-11T21:17:24ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182023-08-0129210.21613/GORM.2022.1342Maternal Serum Fractalkine Concentrations in Pregnancies Complicated by Fetal Growth RestrictionEcem Berfun Toprak Sager 0Ibrahim Kale1Hakan Sager2Aysegul Ozel3Murat Muhcu4Umraniye Training and Research Hospital, Department of Obstetrics and GynecologyUmraniye Training and Research Hospital, Department of Obstetrics and GynecologyBursa Yuksek Ihtisas Research and Training Hospital, Department of Obstetrics and GynecologyUmraniye Training and Research Hospital, Department of Obstetrics and Gynecology, Maternal Fetal UnitUmraniye Training and Research Hospital, Department of Obstetrics and Gynecology, Maternal Fetal Unit OBJECTIVE: Fractalkine is a newly discovered chemokine that is expressed in placental tissue during pregnancy and is subsequently shed into the maternal serum. Although there are a few studies examining the relationship between fractalkine and preeclampsia, its role in isolated fetal growth restriction has not been investigated yet. In this study, we aimed to investigate the relationship between isolated fetal growth restriction and maternal serum fractalkine concentrations. STUDY DESIGN: This cross-sectional study was conducted on 86 pregnant women, 25 of whom were diagnosed with fetal growth restriction in the third trimester, 23 were small for gestational age, and 38 were healthy controls. These three groups were compared in terms of maternal serum fractalkine concentrations. RESULTS: While the highest mean maternal serum fractalkine concentration was found in the small for gestational age group at 23.31 ng/mL, it was determined as 18.06 ng/mL in the fetal growth restriction group and 16.03 ng/mL in the control group. We did not find a statistical difference between the groups in terms of fractalkine concentrations (p=0.258). When the patients with fetal growth restriction and small for gestational age were evaluated as a single group and compared with the control group, the mean fractalkine concentration in the fetal growth restriction+small for gestational age group was higher than the control group, but this difference was not statistically significant (p=0.214). CONCLUSION: Maternal serum fractalkine concentration was higher in both fetal growth restriction and small for gestational age groups compared to healthy controls, but this difference was not statistically significant. The role of the fractalkine molecule in the development of fetal growth restriction remains to be clarified in future studies with larger series. https://gorm.com.tr/index.php/GORM/article/view/1342Fetal growth restrictionFractalkineSmall for gestational age |
| spellingShingle | Ecem Berfun Toprak Sager Ibrahim Kale Hakan Sager Aysegul Ozel Murat Muhcu Maternal Serum Fractalkine Concentrations in Pregnancies Complicated by Fetal Growth Restriction Gynecology Obstetrics & Reproductive Medicine Fetal growth restriction Fractalkine Small for gestational age |
| title | Maternal Serum Fractalkine Concentrations in Pregnancies Complicated by Fetal Growth Restriction |
| title_full | Maternal Serum Fractalkine Concentrations in Pregnancies Complicated by Fetal Growth Restriction |
| title_fullStr | Maternal Serum Fractalkine Concentrations in Pregnancies Complicated by Fetal Growth Restriction |
| title_full_unstemmed | Maternal Serum Fractalkine Concentrations in Pregnancies Complicated by Fetal Growth Restriction |
| title_short | Maternal Serum Fractalkine Concentrations in Pregnancies Complicated by Fetal Growth Restriction |
| title_sort | maternal serum fractalkine concentrations in pregnancies complicated by fetal growth restriction |
| topic | Fetal growth restriction Fractalkine Small for gestational age |
| url | https://gorm.com.tr/index.php/GORM/article/view/1342 |
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