Sympathetic intervention in abdominopelvic cancer pain: A systematic review and meta-analysis
This review aims to investigate the effectiveness of CP, SHP, and GI intervention as a singular or combination to reduce the pain intensity. Medline, Scopus, and CENTRAL databases were used to identify abstracts using predefined search terms. Risk of bias in non-randomized studies - of intervention...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
|
| Series: | World Neurosurgery: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590139725000602 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849716562084233216 |
|---|---|
| author | Made Agus Mahendra Inggas Fandi Hendrawan Amelia Marcelina Kezia Aurelia Tamzil Takaomi Taira |
| author_facet | Made Agus Mahendra Inggas Fandi Hendrawan Amelia Marcelina Kezia Aurelia Tamzil Takaomi Taira |
| author_sort | Made Agus Mahendra Inggas |
| collection | DOAJ |
| description | This review aims to investigate the effectiveness of CP, SHP, and GI intervention as a singular or combination to reduce the pain intensity. Medline, Scopus, and CENTRAL databases were used to identify abstracts using predefined search terms. Risk of bias in non-randomized studies - of intervention tool and Cochrane risk-of-bias tool for randomized trials were applied for risk of bias assessment. This review includes only severe pain defined as visual analogue scale or numeric rating scale (NRS) 7–10. Fifteen articles were included in this study. In general, pain intensity was reduced significantly after the intervention (MD -4.58; 95 %CI -5.25 to −3.91). However, subgroup analysis failed to identify any significant reduction in ganglion Impar group. Regarding morphine consumption, the intervention was significantly subsided the need of morphine (SMD -1.31; 95 %CI -1.86 to −0.76). In meta-regression, follow-up period was significantly moderated the pain changes by increasing 0.43 score within a month after the intervention (p value < 0.01). The limitation of this study lies on the pain assessment that used NRS which is a self-reported evaluation and may lead to self-reported bias. In conclusion, the sympathetic intervention demonstrates its effectiveness in cancer pain. However, since GI intervention mostly failed to reduce the pain severity during the follow up, GI intervention should be used in combination with another intervention. |
| format | Article |
| id | doaj-art-b427aa2fd70c443c890f05f49a487aef |
| institution | DOAJ |
| issn | 2590-1397 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Neurosurgery: X |
| spelling | doaj-art-b427aa2fd70c443c890f05f49a487aef2025-08-20T03:12:57ZengElsevierWorld Neurosurgery: X2590-13972025-07-012710048610.1016/j.wnsx.2025.100486Sympathetic intervention in abdominopelvic cancer pain: A systematic review and meta-analysisMade Agus Mahendra Inggas0Fandi Hendrawan1Amelia Marcelina2Kezia Aurelia Tamzil3Takaomi Taira4Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia; Corresponding author. Faculty of Medicine, Universitas Pelita Harapan, Bencongan, Kelapa Dua, Tangerang Regency, Banten, 15810, Indonesia.Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Special Region of Yogyakarta, IndonesiaFaculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Special Region of Yogyakarta, IndonesiaFaculty of Medicine, Universitas Udayana, Denpasar, Bali, IndonesiaDepartment of Neurosurgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, JapanThis review aims to investigate the effectiveness of CP, SHP, and GI intervention as a singular or combination to reduce the pain intensity. Medline, Scopus, and CENTRAL databases were used to identify abstracts using predefined search terms. Risk of bias in non-randomized studies - of intervention tool and Cochrane risk-of-bias tool for randomized trials were applied for risk of bias assessment. This review includes only severe pain defined as visual analogue scale or numeric rating scale (NRS) 7–10. Fifteen articles were included in this study. In general, pain intensity was reduced significantly after the intervention (MD -4.58; 95 %CI -5.25 to −3.91). However, subgroup analysis failed to identify any significant reduction in ganglion Impar group. Regarding morphine consumption, the intervention was significantly subsided the need of morphine (SMD -1.31; 95 %CI -1.86 to −0.76). In meta-regression, follow-up period was significantly moderated the pain changes by increasing 0.43 score within a month after the intervention (p value < 0.01). The limitation of this study lies on the pain assessment that used NRS which is a self-reported evaluation and may lead to self-reported bias. In conclusion, the sympathetic intervention demonstrates its effectiveness in cancer pain. However, since GI intervention mostly failed to reduce the pain severity during the follow up, GI intervention should be used in combination with another intervention.http://www.sciencedirect.com/science/article/pii/S2590139725000602Sympathetic interventionMorphineCancer painMeta-analysisMeta-regression |
| spellingShingle | Made Agus Mahendra Inggas Fandi Hendrawan Amelia Marcelina Kezia Aurelia Tamzil Takaomi Taira Sympathetic intervention in abdominopelvic cancer pain: A systematic review and meta-analysis World Neurosurgery: X Sympathetic intervention Morphine Cancer pain Meta-analysis Meta-regression |
| title | Sympathetic intervention in abdominopelvic cancer pain: A systematic review and meta-analysis |
| title_full | Sympathetic intervention in abdominopelvic cancer pain: A systematic review and meta-analysis |
| title_fullStr | Sympathetic intervention in abdominopelvic cancer pain: A systematic review and meta-analysis |
| title_full_unstemmed | Sympathetic intervention in abdominopelvic cancer pain: A systematic review and meta-analysis |
| title_short | Sympathetic intervention in abdominopelvic cancer pain: A systematic review and meta-analysis |
| title_sort | sympathetic intervention in abdominopelvic cancer pain a systematic review and meta analysis |
| topic | Sympathetic intervention Morphine Cancer pain Meta-analysis Meta-regression |
| url | http://www.sciencedirect.com/science/article/pii/S2590139725000602 |
| work_keys_str_mv | AT madeagusmahendrainggas sympatheticinterventioninabdominopelviccancerpainasystematicreviewandmetaanalysis AT fandihendrawan sympatheticinterventioninabdominopelviccancerpainasystematicreviewandmetaanalysis AT ameliamarcelina sympatheticinterventioninabdominopelviccancerpainasystematicreviewandmetaanalysis AT keziaaureliatamzil sympatheticinterventioninabdominopelviccancerpainasystematicreviewandmetaanalysis AT takaomitaira sympatheticinterventioninabdominopelviccancerpainasystematicreviewandmetaanalysis |