Estimation and Correlation of Serum C-Reactive Protein in Patients with Oral Squamous Cell Carcinoma
Background: C-reactive protein (CRP) is an early marker of inflammation and disease activity, and is often used as a diagnostic adjunct. Elevated CRP levels have been linked to poor prognosis in esophageal, gastric, and colorectal cancers. This study evaluates the association and correlation of preo...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Indian Academy of Oral Medicine and Radiology |
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| Online Access: | https://journals.lww.com/10.4103/jiaomr.jiaomr_233_24 |
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| author | Khushali H. Shah Sima P. Odedra R V Subramanyam Vandana S. Shah Jayasankar P. Pillai Pratesh N. Dholabhai |
| author_facet | Khushali H. Shah Sima P. Odedra R V Subramanyam Vandana S. Shah Jayasankar P. Pillai Pratesh N. Dholabhai |
| author_sort | Khushali H. Shah |
| collection | DOAJ |
| description | Background:
C-reactive protein (CRP) is an early marker of inflammation and disease activity, and is often used as a diagnostic adjunct. Elevated CRP levels have been linked to poor prognosis in esophageal, gastric, and colorectal cancers. This study evaluates the association and correlation of preoperative serum CRP levels with clinicopathological parameters in oral squamous cell carcinoma (OSCC).
Objectives:
To determine the relationship between elevated CRP levels and histopathologic grading, lymph node metastasis, lesion type, and tobacco habits in OSCC patients.
Methods:
The study included 50 OSCC patients and 30 healthy controls. Preoperative serum CRP levels were measured using a CRP assessment kit. Clinicopathological correlations were analyzed using the Chi-square and analysis of variance tests, with a significance threshold of P < 0.05.
Results:
The mean CRP level was 12.75 mg/dL in OSCC patients, which was significantly higher than in controls (P = 0.004). Elevated CRP levels were correlated with lymph node metastasis (P = 0.024), histopathologic grading (P = 0.035), and tobacco habits, including duration (P = 0.025) and frequency (P = 0.022).
Conclusions:
CRP levels were significantly elevated in OSCC patients compared to healthy controls, demonstrating a strong association with clinicopathological parameters. Elevated CRP may serve as a prognostic biomarker in OSCC. |
| format | Article |
| id | doaj-art-b41e144afbcd40029b9ceb93caa0448b |
| institution | OA Journals |
| issn | 0972-1363 0975-1572 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Academy of Oral Medicine and Radiology |
| spelling | doaj-art-b41e144afbcd40029b9ceb93caa0448b2025-08-20T02:12:25ZengWolters Kluwer Medknow PublicationsJournal of Indian Academy of Oral Medicine and Radiology0972-13630975-15722025-01-01371303410.4103/jiaomr.jiaomr_233_24Estimation and Correlation of Serum C-Reactive Protein in Patients with Oral Squamous Cell CarcinomaKhushali H. ShahSima P. OdedraR V SubramanyamVandana S. ShahJayasankar P. PillaiPratesh N. DholabhaiBackground: C-reactive protein (CRP) is an early marker of inflammation and disease activity, and is often used as a diagnostic adjunct. Elevated CRP levels have been linked to poor prognosis in esophageal, gastric, and colorectal cancers. This study evaluates the association and correlation of preoperative serum CRP levels with clinicopathological parameters in oral squamous cell carcinoma (OSCC). Objectives: To determine the relationship between elevated CRP levels and histopathologic grading, lymph node metastasis, lesion type, and tobacco habits in OSCC patients. Methods: The study included 50 OSCC patients and 30 healthy controls. Preoperative serum CRP levels were measured using a CRP assessment kit. Clinicopathological correlations were analyzed using the Chi-square and analysis of variance tests, with a significance threshold of P < 0.05. Results: The mean CRP level was 12.75 mg/dL in OSCC patients, which was significantly higher than in controls (P = 0.004). Elevated CRP levels were correlated with lymph node metastasis (P = 0.024), histopathologic grading (P = 0.035), and tobacco habits, including duration (P = 0.025) and frequency (P = 0.022). Conclusions: CRP levels were significantly elevated in OSCC patients compared to healthy controls, demonstrating a strong association with clinicopathological parameters. Elevated CRP may serve as a prognostic biomarker in OSCC.https://journals.lww.com/10.4103/jiaomr.jiaomr_233_24biomarkersc-reactive proteincarcinomamouth canceroral squamous cell carcinomaprognosissmokeless tobacco |
| spellingShingle | Khushali H. Shah Sima P. Odedra R V Subramanyam Vandana S. Shah Jayasankar P. Pillai Pratesh N. Dholabhai Estimation and Correlation of Serum C-Reactive Protein in Patients with Oral Squamous Cell Carcinoma Journal of Indian Academy of Oral Medicine and Radiology biomarkers c-reactive protein carcinoma mouth cancer oral squamous cell carcinoma prognosis smokeless tobacco |
| title | Estimation and Correlation of Serum C-Reactive Protein in Patients with Oral Squamous Cell Carcinoma |
| title_full | Estimation and Correlation of Serum C-Reactive Protein in Patients with Oral Squamous Cell Carcinoma |
| title_fullStr | Estimation and Correlation of Serum C-Reactive Protein in Patients with Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Estimation and Correlation of Serum C-Reactive Protein in Patients with Oral Squamous Cell Carcinoma |
| title_short | Estimation and Correlation of Serum C-Reactive Protein in Patients with Oral Squamous Cell Carcinoma |
| title_sort | estimation and correlation of serum c reactive protein in patients with oral squamous cell carcinoma |
| topic | biomarkers c-reactive protein carcinoma mouth cancer oral squamous cell carcinoma prognosis smokeless tobacco |
| url | https://journals.lww.com/10.4103/jiaomr.jiaomr_233_24 |
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