Resistant starch, chronic kidney disease, and the gut microbiome: A mini‐review
Abstract The kidneys play a vital role in maintaining various homeostatic functions, yet the prevalence of chronic kidney disease (CKD) has been increasing globally. The review discusses how resistant starch supplementation in CKD patients can shift the gut microbiota composition, promoting short‐ch...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Food Frontiers |
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| Online Access: | https://doi.org/10.1002/fft2.474 |
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| _version_ | 1850128384765460480 |
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| author | Jiayue Guo Amy Szacilo Lingyan Kong |
| author_facet | Jiayue Guo Amy Szacilo Lingyan Kong |
| author_sort | Jiayue Guo |
| collection | DOAJ |
| description | Abstract The kidneys play a vital role in maintaining various homeostatic functions, yet the prevalence of chronic kidney disease (CKD) has been increasing globally. The review discusses how resistant starch supplementation in CKD patients can shift the gut microbiota composition, promoting short‐chain fatty acid‐producing bacteria, especially butyrate producers, and reducing mucin‐degrading bacteria. This shift is posited to reduce inflammation and oxidative stress, thereby potentially alleviating CKD progression. It also highlights the complexity of establishing clear causal pathways due to the current limitations in testing techniques for gut microbiota, which often lack the resolution needed to establish clear causal mechanisms. Therefore, this review stresses the need for future research to address these gaps, refine testing methods, clarify the health implications of microbiota shifts, and consider individual metabolic differences and variations in gut microbiota. |
| format | Article |
| id | doaj-art-b41cdce2f8c9408ea432b87a64b4c188 |
| institution | OA Journals |
| issn | 2643-8429 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Food Frontiers |
| spelling | doaj-art-b41cdce2f8c9408ea432b87a64b4c1882025-08-20T02:33:19ZengWileyFood Frontiers2643-84292025-01-016151410.1002/fft2.474Resistant starch, chronic kidney disease, and the gut microbiome: A mini‐reviewJiayue Guo0Amy Szacilo1Lingyan Kong2Department of Nutrition and Health Beijing Advanced Innovation Center for Food Nutrition and Human Health China Agricultural University Beijing ChinaDepartment of Human Nutrition Hospitality and Sport Management The University of Alabama Tuscaloosa Alabama USADepartment of Human Nutrition Hospitality and Sport Management The University of Alabama Tuscaloosa Alabama USAAbstract The kidneys play a vital role in maintaining various homeostatic functions, yet the prevalence of chronic kidney disease (CKD) has been increasing globally. The review discusses how resistant starch supplementation in CKD patients can shift the gut microbiota composition, promoting short‐chain fatty acid‐producing bacteria, especially butyrate producers, and reducing mucin‐degrading bacteria. This shift is posited to reduce inflammation and oxidative stress, thereby potentially alleviating CKD progression. It also highlights the complexity of establishing clear causal pathways due to the current limitations in testing techniques for gut microbiota, which often lack the resolution needed to establish clear causal mechanisms. Therefore, this review stresses the need for future research to address these gaps, refine testing methods, clarify the health implications of microbiota shifts, and consider individual metabolic differences and variations in gut microbiota.https://doi.org/10.1002/fft2.474chronic kidney diseasegut microbiomeinflammationoxidative stressresistant starch |
| spellingShingle | Jiayue Guo Amy Szacilo Lingyan Kong Resistant starch, chronic kidney disease, and the gut microbiome: A mini‐review Food Frontiers chronic kidney disease gut microbiome inflammation oxidative stress resistant starch |
| title | Resistant starch, chronic kidney disease, and the gut microbiome: A mini‐review |
| title_full | Resistant starch, chronic kidney disease, and the gut microbiome: A mini‐review |
| title_fullStr | Resistant starch, chronic kidney disease, and the gut microbiome: A mini‐review |
| title_full_unstemmed | Resistant starch, chronic kidney disease, and the gut microbiome: A mini‐review |
| title_short | Resistant starch, chronic kidney disease, and the gut microbiome: A mini‐review |
| title_sort | resistant starch chronic kidney disease and the gut microbiome a mini review |
| topic | chronic kidney disease gut microbiome inflammation oxidative stress resistant starch |
| url | https://doi.org/10.1002/fft2.474 |
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