Development of Severe Hyponatremia due to Salt-Losing Nephropathy after Esophagectomy for Esophageal Cancer
A 72-year-old woman was admitted to our hospital for esophagectomy for esophageal cancer. On the third postoperative day, she developed polyuria (3.8 L/day), massive natriuresis, hyponatremia (112 mEq/L), hyperkalemia (5.6 mEq/L), and decreased central venous pressure, which was refractory to isoton...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2009/241283 |
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| author | Katsunobu Yoshioka Minako Nishio Soichi Sano Katsunobu Sakurai Keiko Yamagami Yoshito Yamashita |
| author_facet | Katsunobu Yoshioka Minako Nishio Soichi Sano Katsunobu Sakurai Keiko Yamagami Yoshito Yamashita |
| author_sort | Katsunobu Yoshioka |
| collection | DOAJ |
| description | A 72-year-old woman was admitted to our hospital for esophagectomy for esophageal cancer. On the third postoperative day, she developed polyuria (3.8 L/day), massive natriuresis, hyponatremia (112 mEq/L), hyperkalemia (5.6 mEq/L), and decreased central venous pressure, which was refractory to isotonic saline infusion. Laboratory findings indicated proximal tubular injury (high urinary β2-microglobulin, coexistence of hypouricemia) together with reduced aldosterone action at the cortical collecting duct. A diagnosis of salt-losing nephropathy was made and sodium correction was done with 3% saline and fludrocortisone. She responded well to therapy. The cause of hyponatremia was considered renal tubular dysfunction together with elevated antidiuretic hormone level. Postoperatively, it is important to look for the development of salt-losing nephropathy. |
| format | Article |
| id | doaj-art-b41b2833d6644ca0a3c9dbee0d9e639e |
| institution | OA Journals |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-b41b2833d6644ca0a3c9dbee0d9e639e2025-08-20T02:23:13ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/241283241283Development of Severe Hyponatremia due to Salt-Losing Nephropathy after Esophagectomy for Esophageal CancerKatsunobu Yoshioka0Minako Nishio1Soichi Sano2Katsunobu Sakurai3Keiko Yamagami4Yoshito Yamashita5Department of Internal Medicine, Osaka City General Hospital, Osaka 534-0021, JapanDepartment of Internal Medicine, Osaka City General Hospital, Osaka 534-0021, JapanDepartment of Internal Medicine, Osaka City General Hospital, Osaka 534-0021, JapanThe Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka 534-0021, JapanDepartment of Internal Medicine, Osaka City General Hospital, Osaka 534-0021, JapanThe Department of Gastroenterological Surgery, Osaka City General Hospital, Osaka 534-0021, JapanA 72-year-old woman was admitted to our hospital for esophagectomy for esophageal cancer. On the third postoperative day, she developed polyuria (3.8 L/day), massive natriuresis, hyponatremia (112 mEq/L), hyperkalemia (5.6 mEq/L), and decreased central venous pressure, which was refractory to isotonic saline infusion. Laboratory findings indicated proximal tubular injury (high urinary β2-microglobulin, coexistence of hypouricemia) together with reduced aldosterone action at the cortical collecting duct. A diagnosis of salt-losing nephropathy was made and sodium correction was done with 3% saline and fludrocortisone. She responded well to therapy. The cause of hyponatremia was considered renal tubular dysfunction together with elevated antidiuretic hormone level. Postoperatively, it is important to look for the development of salt-losing nephropathy.http://dx.doi.org/10.1155/2009/241283 |
| spellingShingle | Katsunobu Yoshioka Minako Nishio Soichi Sano Katsunobu Sakurai Keiko Yamagami Yoshito Yamashita Development of Severe Hyponatremia due to Salt-Losing Nephropathy after Esophagectomy for Esophageal Cancer Case Reports in Medicine |
| title | Development of Severe Hyponatremia due to Salt-Losing Nephropathy after Esophagectomy for Esophageal Cancer |
| title_full | Development of Severe Hyponatremia due to Salt-Losing Nephropathy after Esophagectomy for Esophageal Cancer |
| title_fullStr | Development of Severe Hyponatremia due to Salt-Losing Nephropathy after Esophagectomy for Esophageal Cancer |
| title_full_unstemmed | Development of Severe Hyponatremia due to Salt-Losing Nephropathy after Esophagectomy for Esophageal Cancer |
| title_short | Development of Severe Hyponatremia due to Salt-Losing Nephropathy after Esophagectomy for Esophageal Cancer |
| title_sort | development of severe hyponatremia due to salt losing nephropathy after esophagectomy for esophageal cancer |
| url | http://dx.doi.org/10.1155/2009/241283 |
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