Administration of the KCa channel activator SKA-31 improves endothelial function in the aorta of atherosclerosis-prone mice

Administration of the KCa channel activator SKA-31 improves endothelial function in the aorta of atherosclerosis-prone mice

IntroductionAtherosclerosis remains a major risk factor for vascular dysfunction and cardiovascular (CV) disease. Pharmacological enhancement of endothelial Ca2+-activated K+ channel activity (i.e., KCa2.3 and KCa3.1) opposes vascular dysfunction associated with ageing and type 2 diabetes (T2D) in e...

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Main Authors: O. Daniel Vera, Ramesh C. Mishra, Rayan Khaddaj-Mallat, Liam Hamm, Barak Almarzouq, Yong-Xiang Chen, Darrell D. Belke, Latika Singh, Heike Wulff, Andrew P. Braun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
endothelial dysfunction
KCa channel activator
aorta
atherosclerosis
ApoE knockout mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1545050/full
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