COMPARATIVE RESULTS OF LIVER TRANSPLANTATION IN PATIENTS WITH VIRAL CIRRHOSIS AND AUTOIMMUNE LIVER DISEASES AT A SINGLE CENTER
Russian Scientist Centre for Radiology and Surgical Technology has sufficient experience of orthotopic liver transplantation (100 OLT), which allowed comparing the outcomes of the terminal stages of liver disease in the two most numerous groups of patients: viral cirrhosis (VH) and autoimmune liver...
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2012-03-01
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| Series: | Вестник трансплантологии и искусственных органов |
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| Online Access: | https://journal.transpl.ru/vtio/article/view/110 |
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| author | O.A Gerasimova D.A. Granov F.K. Zherebtsov |
| author_facet | O.A Gerasimova D.A. Granov F.K. Zherebtsov |
| author_sort | O.A Gerasimova |
| collection | DOAJ |
| description | Russian Scientist Centre for Radiology and Surgical Technology has sufficient experience of orthotopic liver transplantation (100 OLT), which allowed comparing the outcomes of the terminal stages of liver disease in the two most numerous groups of patients: viral cirrhosis (VH) and autoimmune liver diseases (AILD). Despite the fact that patients with VH indicator of urgency performing OLT (MELD) lower, rate of deaths on the waiting list higher than AILD, due to more favorable course of immune disease. After OLT significant differences during the early and last posttransplant periods were not found, although the recurrences of viral hepatitis are recorded much more frequently than AILD. One-year and a three-year survival rates were comparable. To prevent reinfection of the hepatitis B successfully used nucleoside analogues (telbivudine), which allowed minimizing recurrence of the disease. Prevention and treatment of hepatitis C after the OLT is a relevant problem, despite the low efficiency of antiviral therapy. Relapses AILD not represent a real threat to the life of the patients, because the modification of immunosuppressive therapy can limit the progression of the disease. |
| format | Article |
| id | doaj-art-b410a03efda64e3494a84e3222fc92bb |
| institution | Kabale University |
| issn | 1995-1191 |
| language | Russian |
| publishDate | 2012-03-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Вестник трансплантологии и искусственных органов |
| spelling | doaj-art-b410a03efda64e3494a84e3222fc92bb2025-08-20T03:59:56ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovВестник трансплантологии и искусственных органов1995-11912012-03-01141364010.15825/1995-1191-2012-1-36-4053COMPARATIVE RESULTS OF LIVER TRANSPLANTATION IN PATIENTS WITH VIRAL CIRRHOSIS AND AUTOIMMUNE LIVER DISEASES AT A SINGLE CENTERO.A Gerasimova0D.A. Granov1F.K. Zherebtsov2Russian Scientific Center of Radiology and Surgical Techology, Saint-PetersburgRussian Scientific Center of Radiology and Surgical Techology, Saint-PetersburgRussian Scientific Center of Radiology and Surgical Techology, Saint-PetersburgRussian Scientist Centre for Radiology and Surgical Technology has sufficient experience of orthotopic liver transplantation (100 OLT), which allowed comparing the outcomes of the terminal stages of liver disease in the two most numerous groups of patients: viral cirrhosis (VH) and autoimmune liver diseases (AILD). Despite the fact that patients with VH indicator of urgency performing OLT (MELD) lower, rate of deaths on the waiting list higher than AILD, due to more favorable course of immune disease. After OLT significant differences during the early and last posttransplant periods were not found, although the recurrences of viral hepatitis are recorded much more frequently than AILD. One-year and a three-year survival rates were comparable. To prevent reinfection of the hepatitis B successfully used nucleoside analogues (telbivudine), which allowed minimizing recurrence of the disease. Prevention and treatment of hepatitis C after the OLT is a relevant problem, despite the low efficiency of antiviral therapy. Relapses AILD not represent a real threat to the life of the patients, because the modification of immunosuppressive therapy can limit the progression of the disease.https://journal.transpl.ru/vtio/article/view/110liver transplantation, waiting list, autoimmune liver diseases, viral hepatitis, cirrhosis. |
| spellingShingle | O.A Gerasimova D.A. Granov F.K. Zherebtsov COMPARATIVE RESULTS OF LIVER TRANSPLANTATION IN PATIENTS WITH VIRAL CIRRHOSIS AND AUTOIMMUNE LIVER DISEASES AT A SINGLE CENTER Вестник трансплантологии и искусственных органов liver transplantation, waiting list, autoimmune liver diseases, viral hepatitis, cirrhosis. |
| title | COMPARATIVE RESULTS OF LIVER TRANSPLANTATION IN PATIENTS WITH VIRAL CIRRHOSIS AND AUTOIMMUNE LIVER DISEASES AT A SINGLE CENTER |
| title_full | COMPARATIVE RESULTS OF LIVER TRANSPLANTATION IN PATIENTS WITH VIRAL CIRRHOSIS AND AUTOIMMUNE LIVER DISEASES AT A SINGLE CENTER |
| title_fullStr | COMPARATIVE RESULTS OF LIVER TRANSPLANTATION IN PATIENTS WITH VIRAL CIRRHOSIS AND AUTOIMMUNE LIVER DISEASES AT A SINGLE CENTER |
| title_full_unstemmed | COMPARATIVE RESULTS OF LIVER TRANSPLANTATION IN PATIENTS WITH VIRAL CIRRHOSIS AND AUTOIMMUNE LIVER DISEASES AT A SINGLE CENTER |
| title_short | COMPARATIVE RESULTS OF LIVER TRANSPLANTATION IN PATIENTS WITH VIRAL CIRRHOSIS AND AUTOIMMUNE LIVER DISEASES AT A SINGLE CENTER |
| title_sort | comparative results of liver transplantation in patients with viral cirrhosis and autoimmune liver diseases at a single center |
| topic | liver transplantation, waiting list, autoimmune liver diseases, viral hepatitis, cirrhosis. |
| url | https://journal.transpl.ru/vtio/article/view/110 |
| work_keys_str_mv | AT oagerasimova comparativeresultsoflivertransplantationinpatientswithviralcirrhosisandautoimmuneliverdiseasesatasinglecenter AT dagranov comparativeresultsoflivertransplantationinpatientswithviralcirrhosisandautoimmuneliverdiseasesatasinglecenter AT fkzherebtsov comparativeresultsoflivertransplantationinpatientswithviralcirrhosisandautoimmuneliverdiseasesatasinglecenter |