Controlled release and antibioticeffect of vancomycin-loaded poly(-isopropylacrylamide) nanoparticles as a smart drug delivery system
Numerous studies have addressed the use of vancomycin (VA) to effectively treat bacterial infections. However, VA is known to cause side effects when administered intravenously. Herein, monodisperse poly( N -isopropylacrylamide) (PNIPAAm) hollow nanocapsules were synthesized at the interface of a wa...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-03-01
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| Series: | Journal of Applied Biomaterials & Functional Materials |
| Online Access: | https://doi.org/10.1177/22808000241291824 |
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| author | Liang Lei Shanlong Li Xuefeng Kang Jian Shang |
| author_facet | Liang Lei Shanlong Li Xuefeng Kang Jian Shang |
| author_sort | Liang Lei |
| collection | DOAJ |
| description | Numerous studies have addressed the use of vancomycin (VA) to effectively treat bacterial infections. However, VA is known to cause side effects when administered intravenously. Herein, monodisperse poly( N -isopropylacrylamide) (PNIPAAm) hollow nanocapsules were synthesized at the interface of a water-in-oil (W/O) single emulsion via Shirasu porous glass (SPG) membrane emulsification and UV-initiated polymerization. In water solutions, the PNIPAAm nanocapsules were able to encapsulate VA and form a new nanoscale water-soluble drug delivery system, namely, PNIPAAm-VA. In vitro experiments showed that PNIPAAm and PNIPAAm-VA had no cytotoxicity toward human bone marrow mesenchymal stem cells. In addition, the slow hydrolysis of PNIPAAm-VA in vitro led to the progressive release of VA, which was discharged at more than 50% and 80% of its initial concentration within 10 days at 37°C and 40°C, respectively; this subsequently inhibited the growth of methicillin-resistant Staphylococcus aureus bacteria. We believe that our PNIPAAm-VA nanoparticles can potentially be used as an effective injectable for temperature-sensitive materials in vivo to achieve the localized controlled release of drugs as safe and specific therapeutic agents. |
| format | Article |
| id | doaj-art-b41055ea2a604665ac090157e3e09a37 |
| institution | DOAJ |
| issn | 2280-8000 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Applied Biomaterials & Functional Materials |
| spelling | doaj-art-b41055ea2a604665ac090157e3e09a372025-08-20T02:53:26ZengSAGE PublishingJournal of Applied Biomaterials & Functional Materials2280-80002025-03-012310.1177/22808000241291824Controlled release and antibioticeffect of vancomycin-loaded poly(-isopropylacrylamide) nanoparticles as a smart drug delivery systemLiang Lei0Shanlong Li1Xuefeng Kang2Jian Shang3Department of Orthopaedics, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, ChinaDepartment of Orthopaedics, People’s Hospital of Qingdao West Coast New Area, Qingdao, Shandong, ChinaDepartment of Orthopaedics, Heilongjiang Provincial Hospital, Harbin, Heilongjiang, ChinaDepartment of Orthopaedics, Shenzhen University General Hospital, Shenzhen, Guangdong, ChinaNumerous studies have addressed the use of vancomycin (VA) to effectively treat bacterial infections. However, VA is known to cause side effects when administered intravenously. Herein, monodisperse poly( N -isopropylacrylamide) (PNIPAAm) hollow nanocapsules were synthesized at the interface of a water-in-oil (W/O) single emulsion via Shirasu porous glass (SPG) membrane emulsification and UV-initiated polymerization. In water solutions, the PNIPAAm nanocapsules were able to encapsulate VA and form a new nanoscale water-soluble drug delivery system, namely, PNIPAAm-VA. In vitro experiments showed that PNIPAAm and PNIPAAm-VA had no cytotoxicity toward human bone marrow mesenchymal stem cells. In addition, the slow hydrolysis of PNIPAAm-VA in vitro led to the progressive release of VA, which was discharged at more than 50% and 80% of its initial concentration within 10 days at 37°C and 40°C, respectively; this subsequently inhibited the growth of methicillin-resistant Staphylococcus aureus bacteria. We believe that our PNIPAAm-VA nanoparticles can potentially be used as an effective injectable for temperature-sensitive materials in vivo to achieve the localized controlled release of drugs as safe and specific therapeutic agents.https://doi.org/10.1177/22808000241291824 |
| spellingShingle | Liang Lei Shanlong Li Xuefeng Kang Jian Shang Controlled release and antibioticeffect of vancomycin-loaded poly(-isopropylacrylamide) nanoparticles as a smart drug delivery system Journal of Applied Biomaterials & Functional Materials |
| title | Controlled release and antibioticeffect of vancomycin-loaded poly(-isopropylacrylamide) nanoparticles as a smart drug delivery system |
| title_full | Controlled release and antibioticeffect of vancomycin-loaded poly(-isopropylacrylamide) nanoparticles as a smart drug delivery system |
| title_fullStr | Controlled release and antibioticeffect of vancomycin-loaded poly(-isopropylacrylamide) nanoparticles as a smart drug delivery system |
| title_full_unstemmed | Controlled release and antibioticeffect of vancomycin-loaded poly(-isopropylacrylamide) nanoparticles as a smart drug delivery system |
| title_short | Controlled release and antibioticeffect of vancomycin-loaded poly(-isopropylacrylamide) nanoparticles as a smart drug delivery system |
| title_sort | controlled release and antibioticeffect of vancomycin loaded poly isopropylacrylamide nanoparticles as a smart drug delivery system |
| url | https://doi.org/10.1177/22808000241291824 |
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