Induction of cell death in malignant cells and regulatory T cells in the tumor microenvironment by targeting CD137

Induction of cell death in malignant cells and regulatory T cells in the tumor microenvironment by targeting CD137

Regulatory T cells (Tregs) contribute significantly to the immunosuppressive nature of the tumor microenvironment which is a main barrier for immunotherapies of solid cancers. Reducing Treg numbers enhances anti-tumor immune responses but current depletion strategies also impair effector T cells (Te...

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Bibliographic Details
Main Authors: Rui Sun, Kang Yi Lee, Yu Mei, Emily Nickles, Jia Le Lin, Runze Xia, Haiyan Liu, Herbert Schwarz
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Antibody
CD137
depletion
regulatory T cell
tumor microenvironment
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2443265
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