Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.
Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using real time RT-PCR on fragments of the 5' and 3' UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-10-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0009860&type=printable |
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| author | Huguette Simo Tchetgna Francine Sado Yousseu Basile Kamgang Armel Tedjou Philip J McCall Charles S Wondji |
| author_facet | Huguette Simo Tchetgna Francine Sado Yousseu Basile Kamgang Armel Tedjou Philip J McCall Charles S Wondji |
| author_sort | Huguette Simo Tchetgna |
| collection | DOAJ |
| description | Acute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using real time RT-PCR on fragments of the 5' and 3' UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 56% (23/41) of the cases were co-infections with malaria. Phylogenetic analysis of the envelope gene identified DENV-1 as belonging to genotype V, DENV-2 to genotype II and DENV-3 to genotype III. The simultaneous occurrence of three serotypes in Douala reveals dengue as a serious public health threat for Cameroon and highlights the need for further epidemiological studies in the major cities of this region. |
| format | Article |
| id | doaj-art-b40ef5f43e4c492a9f03b25e3720f2b3 |
| institution | Kabale University |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2021-10-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-b40ef5f43e4c492a9f03b25e3720f2b32025-08-20T03:25:19ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352021-10-011510e000986010.1371/journal.pntd.0009860Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon.Huguette Simo TchetgnaFrancine Sado YousseuBasile KamgangArmel TedjouPhilip J McCallCharles S WondjiAcute febrile patients presenting at hospitals in Douala, Cameroon between July and December 2020, were screened for dengue infections using real time RT-PCR on fragments of the 5' and 3' UTR genomic regions. In total, 12.8% (41/320) of cases examined were positive for dengue. Dengue virus 3 (DENV-3) was the most common serotype found (68.3%), followed by DENV-2 (19.5%) and DENV-1 (4.9%). Co-infections of DENV-3 and DENV-2 were found in 3 cases. Jaundice and headache were the most frequent clinical signs associated with infection and 56% (23/41) of the cases were co-infections with malaria. Phylogenetic analysis of the envelope gene identified DENV-1 as belonging to genotype V, DENV-2 to genotype II and DENV-3 to genotype III. The simultaneous occurrence of three serotypes in Douala reveals dengue as a serious public health threat for Cameroon and highlights the need for further epidemiological studies in the major cities of this region.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0009860&type=printable |
| spellingShingle | Huguette Simo Tchetgna Francine Sado Yousseu Basile Kamgang Armel Tedjou Philip J McCall Charles S Wondji Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon. PLoS Neglected Tropical Diseases |
| title | Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon. |
| title_full | Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon. |
| title_fullStr | Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon. |
| title_full_unstemmed | Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon. |
| title_short | Concurrent circulation of dengue serotype 1, 2 and 3 among acute febrile patients in Cameroon. |
| title_sort | concurrent circulation of dengue serotype 1 2 and 3 among acute febrile patients in cameroon |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0009860&type=printable |
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