The effects of Stemregen® host modulation therapy on experimentally induced apical periodontitis in rats*
Abstract This study evaluated the effect of Stemregen® nutritional supplement on inflammation and resorption in apical periodontitis using a rat model. Methodology Rats were divided in three groups: negative control (n=7), positive control (n=10), and Stemregen® (Stem) (n=10). Apical periodontitis...
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University of São Paulo
2025-02-01
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| Series: | Journal of Applied Oral Science |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572025000100406&lng=en&tlng=en |
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| author | Fatma GÖNÜLLÜ Mevlüt Sinan OCAK Serkan DUNDAR İbrahim Hanifi ÖZERCAN |
| author_facet | Fatma GÖNÜLLÜ Mevlüt Sinan OCAK Serkan DUNDAR İbrahim Hanifi ÖZERCAN |
| author_sort | Fatma GÖNÜLLÜ |
| collection | DOAJ |
| description | Abstract This study evaluated the effect of Stemregen® nutritional supplement on inflammation and resorption in apical periodontitis using a rat model. Methodology Rats were divided in three groups: negative control (n=7), positive control (n=10), and Stemregen® (Stem) (n=10). Apical periodontitis was induced in the positive control and Stem groups, and all rats were sacrificed on the 30th day. Serum phosphorus (P), calcium (Ca), and alkaline phosphatase (ALP) were analyzed. Histopathological assessments measured osteoblastic and osteoclastic activity, inflammation, fibrosis, and abscess density. Immunohistochemical analyses evaluated RANKL, TRAP, and OPG levels. Results Results showed significantly lower osteoblastic activity in the negative control compared to Stem and positive control groups (p=0.005). Osteoclastic activity was higher in the positive control (p=0.032). Inflammation and abscess formation were reduced in the Stem group compared to the positive control (p<0.001). OPG levels were lower in the negative control compared to the other groups (p=0.005). Conclusion Stemregen® effectively reduced inflammation and bone destruction, suggesting potential benefits for apical periodontitis management, though further research is needed. |
| format | Article |
| id | doaj-art-b40b9831b64949768ec8db859c7a28e2 |
| institution | Kabale University |
| issn | 1678-7765 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | University of São Paulo |
| record_format | Article |
| series | Journal of Applied Oral Science |
| spelling | doaj-art-b40b9831b64949768ec8db859c7a28e22025-02-04T07:39:53ZengUniversity of São PauloJournal of Applied Oral Science1678-77652025-02-013310.1590/1678-7757-2024-0446The effects of Stemregen® host modulation therapy on experimentally induced apical periodontitis in rats*Fatma GÖNÜLLÜhttps://orcid.org/0000-0002-1487-7028Mevlüt Sinan OCAKhttps://orcid.org/0000-0002-3121-2116Serkan DUNDARhttps://orcid.org/0000-0003-3944-1957İbrahim Hanifi ÖZERCANhttps://orcid.org/0000-0002-8781-8838Abstract This study evaluated the effect of Stemregen® nutritional supplement on inflammation and resorption in apical periodontitis using a rat model. Methodology Rats were divided in three groups: negative control (n=7), positive control (n=10), and Stemregen® (Stem) (n=10). Apical periodontitis was induced in the positive control and Stem groups, and all rats were sacrificed on the 30th day. Serum phosphorus (P), calcium (Ca), and alkaline phosphatase (ALP) were analyzed. Histopathological assessments measured osteoblastic and osteoclastic activity, inflammation, fibrosis, and abscess density. Immunohistochemical analyses evaluated RANKL, TRAP, and OPG levels. Results Results showed significantly lower osteoblastic activity in the negative control compared to Stem and positive control groups (p=0.005). Osteoclastic activity was higher in the positive control (p=0.032). Inflammation and abscess formation were reduced in the Stem group compared to the positive control (p<0.001). OPG levels were lower in the negative control compared to the other groups (p=0.005). Conclusion Stemregen® effectively reduced inflammation and bone destruction, suggesting potential benefits for apical periodontitis management, though further research is needed.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572025000100406&lng=en&tlng=enApical periodontitisStemregen®Host modulationRat |
| spellingShingle | Fatma GÖNÜLLÜ Mevlüt Sinan OCAK Serkan DUNDAR İbrahim Hanifi ÖZERCAN The effects of Stemregen® host modulation therapy on experimentally induced apical periodontitis in rats* Journal of Applied Oral Science Apical periodontitis Stemregen® Host modulation Rat |
| title | The effects of Stemregen® host modulation therapy on experimentally induced apical periodontitis in rats* |
| title_full | The effects of Stemregen® host modulation therapy on experimentally induced apical periodontitis in rats* |
| title_fullStr | The effects of Stemregen® host modulation therapy on experimentally induced apical periodontitis in rats* |
| title_full_unstemmed | The effects of Stemregen® host modulation therapy on experimentally induced apical periodontitis in rats* |
| title_short | The effects of Stemregen® host modulation therapy on experimentally induced apical periodontitis in rats* |
| title_sort | effects of stemregen r host modulation therapy on experimentally induced apical periodontitis in rats |
| topic | Apical periodontitis Stemregen® Host modulation Rat |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572025000100406&lng=en&tlng=en |
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