Therapeutic effects of probiotics on symptoms of irritability/emotional lability associated with neurodevelopmental conditions: A systematic review and meta-analysis of placebo-controlled trials
Objectives: The current study aimed at investigating the efficacies of probiotics in alleviating the symptoms of irritability/emotional lability in individuals with a neurodevelopmental condition. Methods: Randomized placebo-controlled trials were identified through searching major electronic databa...
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| Format: | Article |
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Elsevier
2025-05-01
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| Series: | Complementary Therapies in Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S096522992500007X |
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| author | Ping-Wen Huang Chen Chia-Min Cheuk-Kwan Sun Yu-Shian Cheng Yen-Hsiang Tang Cheng Liu Kuo-Chuan Hung |
| author_facet | Ping-Wen Huang Chen Chia-Min Cheuk-Kwan Sun Yu-Shian Cheng Yen-Hsiang Tang Cheng Liu Kuo-Chuan Hung |
| author_sort | Ping-Wen Huang |
| collection | DOAJ |
| description | Objectives: The current study aimed at investigating the efficacies of probiotics in alleviating the symptoms of irritability/emotional lability in individuals with a neurodevelopmental condition. Methods: Randomized placebo-controlled trials were identified through searching major electronic databases from inception to December, 2023. The outcome of interests included improvements in the symptoms of irritability/emotional lability. Outcomes were quantitatively expressed as effect size (ES) based on standardized mean difference (SMD) with 95 % confidence interval (CI). Results: Seven studies with 1479 participants were included in this meta-analysis. The primary results revealed a significant improvement in the symptoms of irritability/emotional lability in individuals with neurodevelopmental conditions receiving probiotics compared with the placebos (SMD= −0.17, p = 0.03). Subgroup analyses demonstrated an association between a significant improvement in the symptoms of irritability/emotional lability and the use probiotics relative to placebos only in studies using multiple-strain probiotics (SMD=-0.19, p = 0.04, three studies with 452 participant) but not in those adopting single-strain regimens. Conclusions: Our study supported the use of probiotics for alleviating the symptoms of irritability/emotional lability in individuals with neurodevelopmental conditions, mainly in those receiving multiple-strain probiotics as supplements. Nevertheless, the limited number of studies targeting irritability as their primary outcomes, and most did not investigate other confounding factors such as dietary habits or consumption of other nutritional supplements may impair the robustness of evidence. Our results, which were derived from a limited number of available trials, warrant further large-scale clinical investigations for verification. |
| format | Article |
| id | doaj-art-b40704d0c681424e87f67e17c85eee70 |
| institution | Kabale University |
| issn | 0965-2299 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Complementary Therapies in Medicine |
| spelling | doaj-art-b40704d0c681424e87f67e17c85eee702025-01-31T05:10:10ZengElsevierComplementary Therapies in Medicine0965-22992025-05-0189103132Therapeutic effects of probiotics on symptoms of irritability/emotional lability associated with neurodevelopmental conditions: A systematic review and meta-analysis of placebo-controlled trialsPing-Wen Huang0Chen Chia-Min1Cheuk-Kwan Sun2Yu-Shian Cheng3Yen-Hsiang Tang4Cheng Liu5Kuo-Chuan Hung6Department of Emergency Medicine, Show Chwan Memorial Hospital, Changhua City, TaiwanDepartment of Natural Biotechnology, Nanhua University, Chiayi, TaiwanDepartment of Emergency Medicine, E-Da Dachang Hospital, I-Shou University, Kaohsiung City, Taiwan; School of Medicine, College of Medicine, I-Shou University, Kaohsiung City, TaiwanDepartment of Psychiatry, Tsyr-Huey Mental Hospital, Kaohsiung Jen-Ai’s Home, TaiwanDepartment of Critical Care Medicine, MacKay Memorial Hospital, Taipei, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, TaiwanDepartment of Physical Education, Huazhong University of Science and Technology, Wuhan 430074, ChinaDepartment of Anesthesiology, Chi Mei Medical Center, Tainan City, Taiwan; Correspondence to: Department of Anesthesiology, Chi Mei Medical Center, Tainan, Taiwan, Chi Mei Medical Center, No.901, ChungHwa Road, YungKung Dist, Tainan 71004, Taiwan.Objectives: The current study aimed at investigating the efficacies of probiotics in alleviating the symptoms of irritability/emotional lability in individuals with a neurodevelopmental condition. Methods: Randomized placebo-controlled trials were identified through searching major electronic databases from inception to December, 2023. The outcome of interests included improvements in the symptoms of irritability/emotional lability. Outcomes were quantitatively expressed as effect size (ES) based on standardized mean difference (SMD) with 95 % confidence interval (CI). Results: Seven studies with 1479 participants were included in this meta-analysis. The primary results revealed a significant improvement in the symptoms of irritability/emotional lability in individuals with neurodevelopmental conditions receiving probiotics compared with the placebos (SMD= −0.17, p = 0.03). Subgroup analyses demonstrated an association between a significant improvement in the symptoms of irritability/emotional lability and the use probiotics relative to placebos only in studies using multiple-strain probiotics (SMD=-0.19, p = 0.04, three studies with 452 participant) but not in those adopting single-strain regimens. Conclusions: Our study supported the use of probiotics for alleviating the symptoms of irritability/emotional lability in individuals with neurodevelopmental conditions, mainly in those receiving multiple-strain probiotics as supplements. Nevertheless, the limited number of studies targeting irritability as their primary outcomes, and most did not investigate other confounding factors such as dietary habits or consumption of other nutritional supplements may impair the robustness of evidence. Our results, which were derived from a limited number of available trials, warrant further large-scale clinical investigations for verification.http://www.sciencedirect.com/science/article/pii/S096522992500007XProbioticsIrritabilityChildren/adolescentMeta-analysis |
| spellingShingle | Ping-Wen Huang Chen Chia-Min Cheuk-Kwan Sun Yu-Shian Cheng Yen-Hsiang Tang Cheng Liu Kuo-Chuan Hung Therapeutic effects of probiotics on symptoms of irritability/emotional lability associated with neurodevelopmental conditions: A systematic review and meta-analysis of placebo-controlled trials Complementary Therapies in Medicine Probiotics Irritability Children/adolescent Meta-analysis |
| title | Therapeutic effects of probiotics on symptoms of irritability/emotional lability associated with neurodevelopmental conditions: A systematic review and meta-analysis of placebo-controlled trials |
| title_full | Therapeutic effects of probiotics on symptoms of irritability/emotional lability associated with neurodevelopmental conditions: A systematic review and meta-analysis of placebo-controlled trials |
| title_fullStr | Therapeutic effects of probiotics on symptoms of irritability/emotional lability associated with neurodevelopmental conditions: A systematic review and meta-analysis of placebo-controlled trials |
| title_full_unstemmed | Therapeutic effects of probiotics on symptoms of irritability/emotional lability associated with neurodevelopmental conditions: A systematic review and meta-analysis of placebo-controlled trials |
| title_short | Therapeutic effects of probiotics on symptoms of irritability/emotional lability associated with neurodevelopmental conditions: A systematic review and meta-analysis of placebo-controlled trials |
| title_sort | therapeutic effects of probiotics on symptoms of irritability emotional lability associated with neurodevelopmental conditions a systematic review and meta analysis of placebo controlled trials |
| topic | Probiotics Irritability Children/adolescent Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S096522992500007X |
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