Single-cell RNA sequencing of circulating immune cells supports inhibition of TNFAIP3 and NFKBIA translation as psoriatic arthritis biomarkers

Single-cell RNA sequencing of circulating immune cells supports inhibition of TNFAIP3 and NFKBIA translation as psoriatic arthritis biomarkers

ObjectiveTo identify biomarkers that distinguish psoriatic arthritis (PsA) from cutaneous psoriasis without arthritis (PsC) and healthy controls (HC) using single cell RNA sequencing (scRNA-seq).MethodPeripheral blood mononuclear cell samples from three patients with PsA fulfilling CASPAR criteria,...

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Bibliographic Details
Main Authors: Ameth N. Garrido, Rohan Machhar, Omar F. Cruz-Correa, Darshini Ganatra, Sarah Q. Crome, Joan Wither, Igor Jurisica, Dafna D. Gladman
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
psoriatic arthritis
psoriasis
scRNA-seq
TNFAIP3
NFKBIA
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1483393/full
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