Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis
BackgroundThe role of sperm DNA fragmentation index (DFI) in fertility remains controversial. Herein, we analyzed its association with semen parameters, embryonic development, and pregnancy outcomes after in vitro fertilization (IVF) treatment. Additionally, we assessed whether DFI had a potential i...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1530972/full |
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| author | Bin Yang Leizhen Xia Rufei Deng Liping Wu Zhiqin Zhang Xingwu Wu Tao Ding Yan Zhao Jialyu Huang Jialyu Huang Zhihui Huang |
| author_facet | Bin Yang Leizhen Xia Rufei Deng Liping Wu Zhiqin Zhang Xingwu Wu Tao Ding Yan Zhao Jialyu Huang Jialyu Huang Zhihui Huang |
| author_sort | Bin Yang |
| collection | DOAJ |
| description | BackgroundThe role of sperm DNA fragmentation index (DFI) in fertility remains controversial. Herein, we analyzed its association with semen parameters, embryonic development, and pregnancy outcomes after in vitro fertilization (IVF) treatment. Additionally, we assessed whether DFI had a potential impact on long-term maternal and neonatal complications.MethodsA total of 5,271 women who underwent IVF treatment for the first time between October 1, 2020, and July 31, 2023, were included from an academic fertility center. Participants were categorized into three groups based on sperm DFI: DFI < 15%, 15 ≤ DFI < 30%, and DFI ≥ 30%. We collected data on patient demographics, semen parameters, embryonic development, clinical outcomes, maternal and infant complications. Multivariate logistic regression analyses were conducted to control for potential confounders.ResultsThe DFI value was negatively correlated with semen quality in males. High DFI affected the blastocyst formation rate (56.44%, 55.32%, 53.72%, respectively; P=0.045) and the rate of transferable embryos (3.97 ± 2.71, 3.90 ± 2.7, 3.38 ± 2.4, respectively; P<0.001); however, no significant difference in pregnancy outcomes was observed among the three groups. Elevated DFI did not contribute to clinically relevant adverse maternal events during pregnancy, but it was associated with an increased risk of low birth weight (3.9%, 6.6%, 10.1%, respectively; P=0.006) in newborns.ConclusionsSperm DFI could influence embryonic development, with a higher risk of low birthweight infants in the high DFI group. However, it does not appear to affect clinical outcomes or other perinatal complications. The role of DFI as a predictive factor in assisted reproduction, especially regarding offspring outcomes, requires further investigation with larger sample sizes. |
| format | Article |
| id | doaj-art-b404994e005c4e83bed95526082a2764 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-b404994e005c4e83bed95526082a27642025-01-21T08:36:58ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.15309721530972Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysisBin Yang0Leizhen Xia1Rufei Deng2Liping Wu3Zhiqin Zhang4Xingwu Wu5Tao Ding6Yan Zhao7Jialyu Huang8Jialyu Huang9Zhihui Huang10Center for Reproductive Medicine, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Nanchang, ChinaCenter for Reproductive Medicine, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Nanchang, ChinaMedical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaCenter for Reproductive Medicine, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Nanchang, ChinaCenter for Reproductive Medicine, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Nanchang, ChinaCenter for Reproductive Medicine, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Nanchang, ChinaCenter for Reproductive Medicine, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Nanchang, ChinaCenter for Reproductive Medicine, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Nanchang, ChinaCenter for Reproductive Medicine, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Nanchang, ChinaBright Prosperity Research Center, Hangzhou, ChinaCenter for Reproductive Medicine, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology, Jiangxi Maternal and Child Health Hospital, Nanchang Medical College, Nanchang, ChinaBackgroundThe role of sperm DNA fragmentation index (DFI) in fertility remains controversial. Herein, we analyzed its association with semen parameters, embryonic development, and pregnancy outcomes after in vitro fertilization (IVF) treatment. Additionally, we assessed whether DFI had a potential impact on long-term maternal and neonatal complications.MethodsA total of 5,271 women who underwent IVF treatment for the first time between October 1, 2020, and July 31, 2023, were included from an academic fertility center. Participants were categorized into three groups based on sperm DFI: DFI < 15%, 15 ≤ DFI < 30%, and DFI ≥ 30%. We collected data on patient demographics, semen parameters, embryonic development, clinical outcomes, maternal and infant complications. Multivariate logistic regression analyses were conducted to control for potential confounders.ResultsThe DFI value was negatively correlated with semen quality in males. High DFI affected the blastocyst formation rate (56.44%, 55.32%, 53.72%, respectively; P=0.045) and the rate of transferable embryos (3.97 ± 2.71, 3.90 ± 2.7, 3.38 ± 2.4, respectively; P<0.001); however, no significant difference in pregnancy outcomes was observed among the three groups. Elevated DFI did not contribute to clinically relevant adverse maternal events during pregnancy, but it was associated with an increased risk of low birth weight (3.9%, 6.6%, 10.1%, respectively; P=0.006) in newborns.ConclusionsSperm DFI could influence embryonic development, with a higher risk of low birthweight infants in the high DFI group. However, it does not appear to affect clinical outcomes or other perinatal complications. The role of DFI as a predictive factor in assisted reproduction, especially regarding offspring outcomes, requires further investigation with larger sample sizes.https://www.frontiersin.org/articles/10.3389/fendo.2024.1530972/fullsperm DNA fragmentation indexembryonic developmentpregnancy outcomesperinatal outcomesneonatal complications |
| spellingShingle | Bin Yang Leizhen Xia Rufei Deng Liping Wu Zhiqin Zhang Xingwu Wu Tao Ding Yan Zhao Jialyu Huang Jialyu Huang Zhihui Huang Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis Frontiers in Endocrinology sperm DNA fragmentation index embryonic development pregnancy outcomes perinatal outcomes neonatal complications |
| title | Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis |
| title_full | Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis |
| title_fullStr | Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis |
| title_full_unstemmed | Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis |
| title_short | Impact of sperm DNA fragmentation index on assisted reproductive outcomes: a retrospective analysis |
| title_sort | impact of sperm dna fragmentation index on assisted reproductive outcomes a retrospective analysis |
| topic | sperm DNA fragmentation index embryonic development pregnancy outcomes perinatal outcomes neonatal complications |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1530972/full |
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