Exploring the role of monocarboxylate transporter 4 in diverse KRAS mutation subtypes of colorectal Cancer

Exploring the role of monocarboxylate transporter 4 in diverse KRAS mutation subtypes of colorectal Cancer

Abstract This study explored the therapeutic potential of monocarboxylate transporter 4 (MCT4/SLC16A3) in KRAS-mutant colorectal cancer (CRC). By integrating immunohistochemistry with UCSC Xena database analysis, we identified a distinct MCT4 expression pattern in KRAS-mutant CRC. Cytoplasmic MCT4 e...

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Bibliographic Details
Main Authors: Qian Gong, Jing Huang, Qingshu Li, Shuxian Zhang, Ming Xiao, Ming Li, Yaying Yang, Yi Tang, Yalan Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Monocarboxylate transporter 4(MCT4)
SLC16A3
Colorectal cancer
KRAS
Immunohistochemistry
Online Access:https://doi.org/10.1038/s41598-025-06254-9
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