A novel and safe SmartCap® SC101 to develop the COVID-19 mRNA vaccine STP2104 inducing potent immune responses in humans

A novel and safe SmartCap® SC101 to develop the COVID-19 mRNA vaccine STP2104 inducing potent immune responses in humans

We have developed a 5′-capping library screening (CLS) method using over 30 different novel cap analogues. The optimal 5′-cap for the coronavirus disease 2019 (COVID-19) mRNA vaccine STP2104 was selected and applied. This is the first report to describe the proven safety of the novel cap analogue, S...

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Main Authors: Rachel Kim, Tae-Gi Uhm, Jisu Kim, Dayeon Woo, Uk-Il Kim, Xue Meng, Byounggu Yang, Suhyeon Kim, Heejene Kim, Jonghyeon Kim, Sunkyung Yoon, Joo-Young Lee, Byungkyun Kim, Dongheon Cho, Duckho Chang, Young-Hwan Cho, Kanghyun Choi, WonSeok Gwak, Hoon-Woo Lee, Jieun Bang, Elizabeth Hellström, Byoungguk Kim, Kyungjin Kim, Joo-Sung Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
mRNA vaccine
COVID-19
SARS-CoV-2
STP2104
human clinical trial study
Capping Library Screening
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1571092/full
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