Changes in Quality of Life, Depression, and Menopausal Symptoms After Surgical Menopause and the Efficacy of Hormone Replacement Therapy in Gynecological Cancer Survivors: A One-Year Prospective Longitudinal Study
<i>Background and Objectives</i>: This study investigated changes in quality of life (QOL), depression, and menopausal symptoms after surgical menopause, and the efficacy of hormone replacement therapy (HRT) in gynecological cancer survivors (GCS). <i>Materials and Methods</i>...
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2025-06-01
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| Online Access: | https://www.mdpi.com/1648-9144/61/7/1191 |
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| author | Noriko Karakida Shintaro Yanazume Natsuko Uchida Mika Sakihama Tsutomu Douchi Hiroaki Kobayashi |
| author_facet | Noriko Karakida Shintaro Yanazume Natsuko Uchida Mika Sakihama Tsutomu Douchi Hiroaki Kobayashi |
| author_sort | Noriko Karakida |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: This study investigated changes in quality of life (QOL), depression, and menopausal symptoms after surgical menopause, and the efficacy of hormone replacement therapy (HRT) in gynecological cancer survivors (GCS). <i>Materials and Methods</i>: Participants undergoing gynecologic cancer surgery (N = 155) were divided into those who received HRT after surgical menopause (SH, N = 47), those after surgical menopause (SM, N = 54), and those after natural menopause (NM, N = 54). QOL, depression, and menopausal symptoms were assessed using the Functional Assessment of Cancer Therapy-General (FACT-G), Center for Epidemiologic Studies Depression Scale (CES-D), and Endocrine Symptoms Subscale-19 (ESS-19), respectively. Assessments were conducted before and at 6 and 12 months after surgery. <i>Results</i>: In SH and SM, FACT-G and CES-D were worst before surgery, gradually improved by 6 months, and remained stable for the following 6 months. FACT-G and CES-D showed an inverse relationship. ESS-19 did not change in SH and SM for 12 months. Among the items on the ESS-19, worsened vasomotor symptoms (VMSs), assessed with ES1, showed more improvement in SH than in SM, while worsened arthralgia assessed with BRM1 was maintained in SM. Multivariate analysis showed that HRT was not independently correlated with changes in QOL and depression status. <i>Conclusions</i>: In GCS, the prevalence of depression was highest at cancer disclosure along with declining QOL. QOL gradually improved by 6 months after surgery in SH and SM, but not in NM. Although menopausal HRT is known to alleviate VMS, anxiety, and depression, its efficacy for cancer-related emotional distress and the associated decline in QOL seems limited. |
| format | Article |
| id | doaj-art-b3fa506f55784e9cae70d1ce79a3ba17 |
| institution | DOAJ |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Medicina |
| spelling | doaj-art-b3fa506f55784e9cae70d1ce79a3ba172025-08-20T03:08:09ZengMDPI AGMedicina1010-660X1648-91442025-06-01617119110.3390/medicina61071191Changes in Quality of Life, Depression, and Menopausal Symptoms After Surgical Menopause and the Efficacy of Hormone Replacement Therapy in Gynecological Cancer Survivors: A One-Year Prospective Longitudinal StudyNoriko Karakida0Shintaro Yanazume1Natsuko Uchida2Mika Sakihama3Tsutomu Douchi4Hiroaki Kobayashi5Department of Obstetrics and Gynecology, Kagoshima University School of Medicine, Kagoshima 890-0075, JapanDepartment of Obstetrics and Gynecology, Kagoshima University School of Medicine, Kagoshima 890-0075, JapanDepartment of Obstetrics and Gynecology, Kagoshima University School of Medicine, Kagoshima 890-0075, JapanDepartment of Obstetrics and Gynecology, Kagoshima University School of Medicine, Kagoshima 890-0075, JapanDepartment of Obstetrics and Gynecology, Kagoshima University School of Medicine, Kagoshima 890-0075, JapanDepartment of Obstetrics and Gynecology, Kagoshima University School of Medicine, Kagoshima 890-0075, Japan<i>Background and Objectives</i>: This study investigated changes in quality of life (QOL), depression, and menopausal symptoms after surgical menopause, and the efficacy of hormone replacement therapy (HRT) in gynecological cancer survivors (GCS). <i>Materials and Methods</i>: Participants undergoing gynecologic cancer surgery (N = 155) were divided into those who received HRT after surgical menopause (SH, N = 47), those after surgical menopause (SM, N = 54), and those after natural menopause (NM, N = 54). QOL, depression, and menopausal symptoms were assessed using the Functional Assessment of Cancer Therapy-General (FACT-G), Center for Epidemiologic Studies Depression Scale (CES-D), and Endocrine Symptoms Subscale-19 (ESS-19), respectively. Assessments were conducted before and at 6 and 12 months after surgery. <i>Results</i>: In SH and SM, FACT-G and CES-D were worst before surgery, gradually improved by 6 months, and remained stable for the following 6 months. FACT-G and CES-D showed an inverse relationship. ESS-19 did not change in SH and SM for 12 months. Among the items on the ESS-19, worsened vasomotor symptoms (VMSs), assessed with ES1, showed more improvement in SH than in SM, while worsened arthralgia assessed with BRM1 was maintained in SM. Multivariate analysis showed that HRT was not independently correlated with changes in QOL and depression status. <i>Conclusions</i>: In GCS, the prevalence of depression was highest at cancer disclosure along with declining QOL. QOL gradually improved by 6 months after surgery in SH and SM, but not in NM. Although menopausal HRT is known to alleviate VMS, anxiety, and depression, its efficacy for cancer-related emotional distress and the associated decline in QOL seems limited.https://www.mdpi.com/1648-9144/61/7/1191gynecological cancer survivorsquality of lifesurgical menopausemenopausal symptomsdepressionhormone replacement therapy |
| spellingShingle | Noriko Karakida Shintaro Yanazume Natsuko Uchida Mika Sakihama Tsutomu Douchi Hiroaki Kobayashi Changes in Quality of Life, Depression, and Menopausal Symptoms After Surgical Menopause and the Efficacy of Hormone Replacement Therapy in Gynecological Cancer Survivors: A One-Year Prospective Longitudinal Study Medicina gynecological cancer survivors quality of life surgical menopause menopausal symptoms depression hormone replacement therapy |
| title | Changes in Quality of Life, Depression, and Menopausal Symptoms After Surgical Menopause and the Efficacy of Hormone Replacement Therapy in Gynecological Cancer Survivors: A One-Year Prospective Longitudinal Study |
| title_full | Changes in Quality of Life, Depression, and Menopausal Symptoms After Surgical Menopause and the Efficacy of Hormone Replacement Therapy in Gynecological Cancer Survivors: A One-Year Prospective Longitudinal Study |
| title_fullStr | Changes in Quality of Life, Depression, and Menopausal Symptoms After Surgical Menopause and the Efficacy of Hormone Replacement Therapy in Gynecological Cancer Survivors: A One-Year Prospective Longitudinal Study |
| title_full_unstemmed | Changes in Quality of Life, Depression, and Menopausal Symptoms After Surgical Menopause and the Efficacy of Hormone Replacement Therapy in Gynecological Cancer Survivors: A One-Year Prospective Longitudinal Study |
| title_short | Changes in Quality of Life, Depression, and Menopausal Symptoms After Surgical Menopause and the Efficacy of Hormone Replacement Therapy in Gynecological Cancer Survivors: A One-Year Prospective Longitudinal Study |
| title_sort | changes in quality of life depression and menopausal symptoms after surgical menopause and the efficacy of hormone replacement therapy in gynecological cancer survivors a one year prospective longitudinal study |
| topic | gynecological cancer survivors quality of life surgical menopause menopausal symptoms depression hormone replacement therapy |
| url | https://www.mdpi.com/1648-9144/61/7/1191 |
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