The Association with Subclinical Thyroid Dysfunction and Uric Acid
The relationship between subclinical thyroid dysfunction and uric acid was not well established. This study aimed to determine if subclinical thyroid dysfunction is associated with hyperuricemia risk and to evaluate the levels of uric acid in patients with different forms of subclinical thyroid dysf...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2021/9720618 |
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| author | Yuling Xing Linlin Yang Jing Liu Huijuan Ma |
| author_facet | Yuling Xing Linlin Yang Jing Liu Huijuan Ma |
| author_sort | Yuling Xing |
| collection | DOAJ |
| description | The relationship between subclinical thyroid dysfunction and uric acid was not well established. This study aimed to determine if subclinical thyroid dysfunction is associated with hyperuricemia risk and to evaluate the levels of uric acid in patients with different forms of subclinical thyroid dysfunction. A systematic search was conducted in 4 databases to obtain relevant studies on subclinical thyroid dysfunction (subclinical hyperthyroidism and subclinical hypothyroidism) and uric acid. The standardized mean difference (SMD) or odds ratio (OR) and 95% confidence interval (95% CI) were used for evaluation, and the sensitivity analysis was conducted. Publication bias was estimated by funnel plot, Egger’s test, and Begg’s test. A total of 73 studies were included in this meta-analysis. The results demonstrated that serum levels of uric acid in patients with subclinical hypothyroidism were significantly higher than those of controls and patients with subclinical hyperthyroidism. Patients with subclinical thyroid dysfunction had a higher prevalence of hyperuricemia compared with normal clinical thyroid function. Subclinical thyroid dysfunction was associated with the prevalence of hyperuricemia. Different types of subclinical thyroid dysfunction had varied effects on serum levels of uric acid. |
| format | Article |
| id | doaj-art-b3f9d6c75f61489ab4e47294e004072b |
| institution | OA Journals |
| issn | 1687-8345 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-b3f9d6c75f61489ab4e47294e004072b2025-08-20T02:23:14ZengWileyInternational Journal of Endocrinology1687-83452021-01-01202110.1155/2021/9720618The Association with Subclinical Thyroid Dysfunction and Uric AcidYuling Xing0Linlin Yang1Jing Liu2Huijuan Ma3Department of EndocrinologyHebei Key Laboratory of Metabolic DiseasesDepartment of EndocrinologyDepartment of EndocrinologyThe relationship between subclinical thyroid dysfunction and uric acid was not well established. This study aimed to determine if subclinical thyroid dysfunction is associated with hyperuricemia risk and to evaluate the levels of uric acid in patients with different forms of subclinical thyroid dysfunction. A systematic search was conducted in 4 databases to obtain relevant studies on subclinical thyroid dysfunction (subclinical hyperthyroidism and subclinical hypothyroidism) and uric acid. The standardized mean difference (SMD) or odds ratio (OR) and 95% confidence interval (95% CI) were used for evaluation, and the sensitivity analysis was conducted. Publication bias was estimated by funnel plot, Egger’s test, and Begg’s test. A total of 73 studies were included in this meta-analysis. The results demonstrated that serum levels of uric acid in patients with subclinical hypothyroidism were significantly higher than those of controls and patients with subclinical hyperthyroidism. Patients with subclinical thyroid dysfunction had a higher prevalence of hyperuricemia compared with normal clinical thyroid function. Subclinical thyroid dysfunction was associated with the prevalence of hyperuricemia. Different types of subclinical thyroid dysfunction had varied effects on serum levels of uric acid.http://dx.doi.org/10.1155/2021/9720618 |
| spellingShingle | Yuling Xing Linlin Yang Jing Liu Huijuan Ma The Association with Subclinical Thyroid Dysfunction and Uric Acid International Journal of Endocrinology |
| title | The Association with Subclinical Thyroid Dysfunction and Uric Acid |
| title_full | The Association with Subclinical Thyroid Dysfunction and Uric Acid |
| title_fullStr | The Association with Subclinical Thyroid Dysfunction and Uric Acid |
| title_full_unstemmed | The Association with Subclinical Thyroid Dysfunction and Uric Acid |
| title_short | The Association with Subclinical Thyroid Dysfunction and Uric Acid |
| title_sort | association with subclinical thyroid dysfunction and uric acid |
| url | http://dx.doi.org/10.1155/2021/9720618 |
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