Debunking Myths and Misinformation in Cervical Cancer: A Narrative Review on Navigating Complex Treatment Choices in Locally Advanced Cases and Exploring Beyond Standard Protocols
Cervical cancer remains a significant health challenge globally, with locally advanced cervical cancer (LACC) representing a particularly complex subset due to its diverse definitions and varied treatment approaches. The absence of randomized controlled trials comparing the upfront radical surgery f...
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MDPI AG
2025-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/9/1174 |
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| author | Mustafa Zelal Muallem Ahmad Sayasneh |
| author_facet | Mustafa Zelal Muallem Ahmad Sayasneh |
| author_sort | Mustafa Zelal Muallem |
| collection | DOAJ |
| description | Cervical cancer remains a significant health challenge globally, with locally advanced cervical cancer (LACC) representing a particularly complex subset due to its diverse definitions and varied treatment approaches. The absence of randomized controlled trials comparing the upfront radical surgery followed by concurrent chemoradiotherapy (CCRT) or chemotherapy alone for clearly defined risk factors for LACC hinders the development of standardized treatment protocols, leading to disparities in patient outcomes across different healthcare settings. This paper seeks to underline the necessity of a consensus on the definition of LACC and aims to comprehensively and critically review the existing literature trying to harmonize treatment strategies and improve prognostic outcomes. Our analysis suggests a multimodal approach for treating FIGO IB3, IIA2, and selected IIB cases at facilities capable of delivering highly curative nerve-sparing surgical interventions, with the goal of bridging the gap in current treatment methodologies. Preliminary findings suggest that adopting a standardized definition could facilitate more consistent treatment outcomes and enhance comparative research. |
| format | Article |
| id | doaj-art-b3f4249024b64056ac3cc22ab969dcba |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-b3f4249024b64056ac3cc22ab969dcba2025-08-20T02:24:47ZengMDPI AGDiagnostics2075-44182025-05-01159117410.3390/diagnostics15091174Debunking Myths and Misinformation in Cervical Cancer: A Narrative Review on Navigating Complex Treatment Choices in Locally Advanced Cases and Exploring Beyond Standard ProtocolsMustafa Zelal Muallem0Ahmad Sayasneh1Department of Gynecology with Center for Oncological Surgery, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Virchow Campus Clinic, Charité Medical University, 13353 Berlin, GermanyDepartment of Gynecological Oncology, Guy’s and St Thomas’ NHS Foundation Trust, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King’s College London, Westminster Bridge Road, London SE1 7EH, UKCervical cancer remains a significant health challenge globally, with locally advanced cervical cancer (LACC) representing a particularly complex subset due to its diverse definitions and varied treatment approaches. The absence of randomized controlled trials comparing the upfront radical surgery followed by concurrent chemoradiotherapy (CCRT) or chemotherapy alone for clearly defined risk factors for LACC hinders the development of standardized treatment protocols, leading to disparities in patient outcomes across different healthcare settings. This paper seeks to underline the necessity of a consensus on the definition of LACC and aims to comprehensively and critically review the existing literature trying to harmonize treatment strategies and improve prognostic outcomes. Our analysis suggests a multimodal approach for treating FIGO IB3, IIA2, and selected IIB cases at facilities capable of delivering highly curative nerve-sparing surgical interventions, with the goal of bridging the gap in current treatment methodologies. Preliminary findings suggest that adopting a standardized definition could facilitate more consistent treatment outcomes and enhance comparative research.https://www.mdpi.com/2075-4418/15/9/1174locally advanced cervical cancermultimodal therapychemoradiotherapyradical surgerypersonalized medicine |
| spellingShingle | Mustafa Zelal Muallem Ahmad Sayasneh Debunking Myths and Misinformation in Cervical Cancer: A Narrative Review on Navigating Complex Treatment Choices in Locally Advanced Cases and Exploring Beyond Standard Protocols Diagnostics locally advanced cervical cancer multimodal therapy chemoradiotherapy radical surgery personalized medicine |
| title | Debunking Myths and Misinformation in Cervical Cancer: A Narrative Review on Navigating Complex Treatment Choices in Locally Advanced Cases and Exploring Beyond Standard Protocols |
| title_full | Debunking Myths and Misinformation in Cervical Cancer: A Narrative Review on Navigating Complex Treatment Choices in Locally Advanced Cases and Exploring Beyond Standard Protocols |
| title_fullStr | Debunking Myths and Misinformation in Cervical Cancer: A Narrative Review on Navigating Complex Treatment Choices in Locally Advanced Cases and Exploring Beyond Standard Protocols |
| title_full_unstemmed | Debunking Myths and Misinformation in Cervical Cancer: A Narrative Review on Navigating Complex Treatment Choices in Locally Advanced Cases and Exploring Beyond Standard Protocols |
| title_short | Debunking Myths and Misinformation in Cervical Cancer: A Narrative Review on Navigating Complex Treatment Choices in Locally Advanced Cases and Exploring Beyond Standard Protocols |
| title_sort | debunking myths and misinformation in cervical cancer a narrative review on navigating complex treatment choices in locally advanced cases and exploring beyond standard protocols |
| topic | locally advanced cervical cancer multimodal therapy chemoradiotherapy radical surgery personalized medicine |
| url | https://www.mdpi.com/2075-4418/15/9/1174 |
| work_keys_str_mv | AT mustafazelalmuallem debunkingmythsandmisinformationincervicalcanceranarrativereviewonnavigatingcomplextreatmentchoicesinlocallyadvancedcasesandexploringbeyondstandardprotocols AT ahmadsayasneh debunkingmythsandmisinformationincervicalcanceranarrativereviewonnavigatingcomplextreatmentchoicesinlocallyadvancedcasesandexploringbeyondstandardprotocols |