The association between active and passive tobacco smoke exposures and epilepsy in United States participants of the National Health and Nutrition Examination Survey (2013–2018)
BackgroundEpilepsy is a common chronic neurological disease, and identifying modifiable risk factors for epilepsy and seizure is extremely important. Currently, the relationship between tobacco exposure and epilepsy or seizure is controversy.ObjectiveThe objective of this study is to test the relati...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1502894/full |
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| author | Tingting Song Chunlan Jia Qi Wang Jie Mu Jie Mu |
| author_facet | Tingting Song Chunlan Jia Qi Wang Jie Mu Jie Mu |
| author_sort | Tingting Song |
| collection | DOAJ |
| description | BackgroundEpilepsy is a common chronic neurological disease, and identifying modifiable risk factors for epilepsy and seizure is extremely important. Currently, the relationship between tobacco exposure and epilepsy or seizure is controversy.ObjectiveThe objective of this study is to test the relationship between tobacco smoke exposures and epilepsy in United States (US) participants of the National Health and Nutrition Examination Survey (NHANES).MethodsThis is a cross-sectional study using data from NHANES 2013–2018. We included all participants in these cycles and excluded those with missing variables. Weighted logistic regression models, weighted sensitivity analysis and weighted subgroup analysis were conducted to estimate the association between active and passive tobacco smoke exposures and epilepsy.ResultsWe included 15,277 participants in NHANES, of whom 131 reported with epilepsy [taking at least one antiseizure medication (ASM) for epilepsy and recurrent seizures]. The weighted mean age of individuals is 42.35 years, 49.08% (95% confidence interval [CI] 48.03–50.12) were male, 64.56% (95%CI 63.70–65.41) were Non-Hispanic White, and 59.95% (95%CI 58.98–60.92) were private insurance. The weighted prevalence of epilepsy was 0.82% (95%CI 0.60–1.11) and 0.60% (95%CI 0.42–0.86) in those with and without tobacco smoke exposures, respectively. After adjusting for covariates, active and passive tobacco smoke exposure was not associated with epilepsy [weighted adjusted odd ratio (OR) 1.16, 95% CI 0.68–1.98, p-value = 0.576] and the results remained in multiple sensitivity analyses. However, we found that tobacco exposure was a protective factor for epilepsy in those aged 40–50 (OR 0.23, 95%CI 0.10–0.53, p-value < 0.001).ConclusionIn summary, tobacco exposure was not associated with epilepsy in the US population and this result remained after adjusting for confounding factors, and the sensitivity analysis was robust. However, in stratified analysis, tobacco exposure was a protective factor for epilepsy patients aged 40–50. |
| format | Article |
| id | doaj-art-b3f1c2db6401458fa13c0dfee859c62b |
| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-b3f1c2db6401458fa13c0dfee859c62b2025-08-20T02:28:16ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-05-011610.3389/fneur.2025.15028941502894The association between active and passive tobacco smoke exposures and epilepsy in United States participants of the National Health and Nutrition Examination Survey (2013–2018)Tingting Song0Chunlan Jia1Qi Wang2Jie Mu3Jie Mu4Department of Neurology, West China Xiamen Hospital, Sichuan University, Xiamen, ChinaCenter for Neurological Function Test and Neuromodulation, West China Xiamen Hospital, Sichuan University, Xiamen, ChinaDepartment of Neurology, West China Xiamen Hospital, Sichuan University, Xiamen, ChinaDepartment of Neurology, West China Xiamen Hospital, Sichuan University, Xiamen, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, ChinaBackgroundEpilepsy is a common chronic neurological disease, and identifying modifiable risk factors for epilepsy and seizure is extremely important. Currently, the relationship between tobacco exposure and epilepsy or seizure is controversy.ObjectiveThe objective of this study is to test the relationship between tobacco smoke exposures and epilepsy in United States (US) participants of the National Health and Nutrition Examination Survey (NHANES).MethodsThis is a cross-sectional study using data from NHANES 2013–2018. We included all participants in these cycles and excluded those with missing variables. Weighted logistic regression models, weighted sensitivity analysis and weighted subgroup analysis were conducted to estimate the association between active and passive tobacco smoke exposures and epilepsy.ResultsWe included 15,277 participants in NHANES, of whom 131 reported with epilepsy [taking at least one antiseizure medication (ASM) for epilepsy and recurrent seizures]. The weighted mean age of individuals is 42.35 years, 49.08% (95% confidence interval [CI] 48.03–50.12) were male, 64.56% (95%CI 63.70–65.41) were Non-Hispanic White, and 59.95% (95%CI 58.98–60.92) were private insurance. The weighted prevalence of epilepsy was 0.82% (95%CI 0.60–1.11) and 0.60% (95%CI 0.42–0.86) in those with and without tobacco smoke exposures, respectively. After adjusting for covariates, active and passive tobacco smoke exposure was not associated with epilepsy [weighted adjusted odd ratio (OR) 1.16, 95% CI 0.68–1.98, p-value = 0.576] and the results remained in multiple sensitivity analyses. However, we found that tobacco exposure was a protective factor for epilepsy in those aged 40–50 (OR 0.23, 95%CI 0.10–0.53, p-value < 0.001).ConclusionIn summary, tobacco exposure was not associated with epilepsy in the US population and this result remained after adjusting for confounding factors, and the sensitivity analysis was robust. However, in stratified analysis, tobacco exposure was a protective factor for epilepsy patients aged 40–50.https://www.frontiersin.org/articles/10.3389/fneur.2025.1502894/fullepilepsyseizuretobacco smoke exposurescotininenicotineNHANES |
| spellingShingle | Tingting Song Chunlan Jia Qi Wang Jie Mu Jie Mu The association between active and passive tobacco smoke exposures and epilepsy in United States participants of the National Health and Nutrition Examination Survey (2013–2018) Frontiers in Neurology epilepsy seizure tobacco smoke exposures cotinine nicotine NHANES |
| title | The association between active and passive tobacco smoke exposures and epilepsy in United States participants of the National Health and Nutrition Examination Survey (2013–2018) |
| title_full | The association between active and passive tobacco smoke exposures and epilepsy in United States participants of the National Health and Nutrition Examination Survey (2013–2018) |
| title_fullStr | The association between active and passive tobacco smoke exposures and epilepsy in United States participants of the National Health and Nutrition Examination Survey (2013–2018) |
| title_full_unstemmed | The association between active and passive tobacco smoke exposures and epilepsy in United States participants of the National Health and Nutrition Examination Survey (2013–2018) |
| title_short | The association between active and passive tobacco smoke exposures and epilepsy in United States participants of the National Health and Nutrition Examination Survey (2013–2018) |
| title_sort | association between active and passive tobacco smoke exposures and epilepsy in united states participants of the national health and nutrition examination survey 2013 2018 |
| topic | epilepsy seizure tobacco smoke exposures cotinine nicotine NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1502894/full |
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