Seroprevalence of transfusion-transmissible infections among family replacement donors and voluntary non-remunerated blood donors during the COVID-19 pandemic in sub Saharan Africa
Introduction : According to WHO, regular, voluntary, unpaid blood donors are the safest group of donors, as they have the lowest prevalence of blood transmitted infections. However, family/replacement blood donors is widely used in sub Saharan Africa and this practice was exacerbated during the CO...
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| Language: | English |
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PAGEPress Publications
2024-01-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://mjhid.org/mjhid/article/view/5529 |
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| author | Macoura Gadji Youssou Bamar Gueye David Motto Saliou Diop |
| author_facet | Macoura Gadji Youssou Bamar Gueye David Motto Saliou Diop |
| author_sort | Macoura Gadji |
| collection | DOAJ |
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Introduction : According to WHO, regular, voluntary, unpaid blood donors are the safest group of donors, as they have the lowest prevalence of blood transmitted infections. However, family/replacement blood donors is widely used in sub Saharan Africa and this practice was exacerbated during the COVID 19 pandemic. This study aimed to compare the seroprevalence of infectious markers in family replacement blood donors and voluntary non-remunerated blood donors during the COVID 19 pandemic in a country of sub Saharan Africa.
Materials and Methods
Blood donors received at the National Centre of Blood Transfusion (NBTC) of Dakar from August 1st to October 31th 2021, were included in this study. All donors completed a pre-donation questionnaire. Donors identity, epidemiological parameters, reasons for donation and laboratory results were collected in the Inlog® software of the NBTC. The serological tests for HBV, HIV and HCV were performed with chemiluminescence technology. The Rapid Plasma Reagent test was used to find out treponemal antibodies. The determination of ABO and Rh blood groups was performed using monoclonal antisera following classical hemagglutination test on a plate.
Results
A total of 5002 donors were collected during this COVID-19 pandemic period. Blood family/replacement donors represented 54.0% and new voluntary donors represented 52.6%. Comparison of HIV, HCV and syphilis markers seroprevalence showed no statistically significant difference between new voluntary donors and new family replacement donors (p>0.05). However, for HBV the seroprevalence was significantly higher in new family replacement donors (p=0,002).
Conclusion
The proper supply of blood was impacted by the COVID-19 pandemic meanwhile replacement donations had contributed to limiting the damage observed with blood shortages. However, the significant differences noted on the seroprevalences of transfusion-transmissible infections between voluntary non-paid donors and family/replacement donors strengthens WHO recommendations for the selection of volunteer non-paid donors to lower transfusion-transmissible HBV in sub Saharan Africa.
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| format | Article |
| id | doaj-art-b3eed8eceb8d4538816d4c1a5ff8069e |
| institution | DOAJ |
| issn | 2035-3006 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-b3eed8eceb8d4538816d4c1a5ff8069e2025-08-20T02:43:00ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062024-01-0116110.4084/MJHID.2024.008Seroprevalence of transfusion-transmissible infections among family replacement donors and voluntary non-remunerated blood donors during the COVID-19 pandemic in sub Saharan AfricaMacoura Gadji0Youssou Bamar Gueye1David Motto2Saliou Diop3National Centre of blood Transfusion (NCBT) of Dakar, Senegal, National Centre of Blood Transfusion (NCBT) of Dakar, Senegal 2- Service of Haematology & Oncology-Haematology (HBOH), Department of Biology and Applied Pharmaceutical Sciences; Faculty of Medicine, Pharmacy and Odonto-Stomatology (FMPOS), University Cheikh Anta Diop of Dakar (UCAD), DakarNational Centre of Blood Transfusion (NCBT) of DakarNational Centre of Blood Transfusion (NCBT) of DakarNational Centre of Blood Transfusion (NCBT) of Dakar, Senegal; Service of Haematology, Department of Medicine; Faculty of Medicine, Pharmacy and Odonto-Stomatology (FMPOS), University Cheikh Anta Diop of Dakar (UCAD), Dakar Introduction : According to WHO, regular, voluntary, unpaid blood donors are the safest group of donors, as they have the lowest prevalence of blood transmitted infections. However, family/replacement blood donors is widely used in sub Saharan Africa and this practice was exacerbated during the COVID 19 pandemic. This study aimed to compare the seroprevalence of infectious markers in family replacement blood donors and voluntary non-remunerated blood donors during the COVID 19 pandemic in a country of sub Saharan Africa. Materials and Methods Blood donors received at the National Centre of Blood Transfusion (NBTC) of Dakar from August 1st to October 31th 2021, were included in this study. All donors completed a pre-donation questionnaire. Donors identity, epidemiological parameters, reasons for donation and laboratory results were collected in the Inlog® software of the NBTC. The serological tests for HBV, HIV and HCV were performed with chemiluminescence technology. The Rapid Plasma Reagent test was used to find out treponemal antibodies. The determination of ABO and Rh blood groups was performed using monoclonal antisera following classical hemagglutination test on a plate. Results A total of 5002 donors were collected during this COVID-19 pandemic period. Blood family/replacement donors represented 54.0% and new voluntary donors represented 52.6%. Comparison of HIV, HCV and syphilis markers seroprevalence showed no statistically significant difference between new voluntary donors and new family replacement donors (p>0.05). However, for HBV the seroprevalence was significantly higher in new family replacement donors (p=0,002). Conclusion The proper supply of blood was impacted by the COVID-19 pandemic meanwhile replacement donations had contributed to limiting the damage observed with blood shortages. However, the significant differences noted on the seroprevalences of transfusion-transmissible infections between voluntary non-paid donors and family/replacement donors strengthens WHO recommendations for the selection of volunteer non-paid donors to lower transfusion-transmissible HBV in sub Saharan Africa. https://mjhid.org/mjhid/article/view/5529Blood donorsreplacement donorunpaid voluntary donortransfusions transmissible infectionsHBSHIV |
| spellingShingle | Macoura Gadji Youssou Bamar Gueye David Motto Saliou Diop Seroprevalence of transfusion-transmissible infections among family replacement donors and voluntary non-remunerated blood donors during the COVID-19 pandemic in sub Saharan Africa Mediterranean Journal of Hematology and Infectious Diseases Blood donors replacement donor unpaid voluntary donor transfusions transmissible infections HBS HIV |
| title | Seroprevalence of transfusion-transmissible infections among family replacement donors and voluntary non-remunerated blood donors during the COVID-19 pandemic in sub Saharan Africa |
| title_full | Seroprevalence of transfusion-transmissible infections among family replacement donors and voluntary non-remunerated blood donors during the COVID-19 pandemic in sub Saharan Africa |
| title_fullStr | Seroprevalence of transfusion-transmissible infections among family replacement donors and voluntary non-remunerated blood donors during the COVID-19 pandemic in sub Saharan Africa |
| title_full_unstemmed | Seroprevalence of transfusion-transmissible infections among family replacement donors and voluntary non-remunerated blood donors during the COVID-19 pandemic in sub Saharan Africa |
| title_short | Seroprevalence of transfusion-transmissible infections among family replacement donors and voluntary non-remunerated blood donors during the COVID-19 pandemic in sub Saharan Africa |
| title_sort | seroprevalence of transfusion transmissible infections among family replacement donors and voluntary non remunerated blood donors during the covid 19 pandemic in sub saharan africa |
| topic | Blood donors replacement donor unpaid voluntary donor transfusions transmissible infections HBS HIV |
| url | https://mjhid.org/mjhid/article/view/5529 |
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