Functional characterization and therapeutic potential of human umbilical cord blood mononuclear cells
Human umbilical cord blood mononuclear cells (hUCB-MNCs) are a population of cells derived from neonatal cord blood, encompassing various stem cells and immune cells. The unique characteristics of hUCB-MNCs endow them with distinctive multifunctionality, including the promotion of angiogenesis, acce...
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Elsevier
2025-03-01
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| Series: | Regenerative Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352320424002116 |
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| author | Yu Zhang Yueda Lu Xinyue Hu Mengxing Jiang Zhixiu Chen Lingkun Jin Min Li Chen Chen Jianye Wang |
| author_facet | Yu Zhang Yueda Lu Xinyue Hu Mengxing Jiang Zhixiu Chen Lingkun Jin Min Li Chen Chen Jianye Wang |
| author_sort | Yu Zhang |
| collection | DOAJ |
| description | Human umbilical cord blood mononuclear cells (hUCB-MNCs) are a population of cells derived from neonatal cord blood, encompassing various stem cells and immune cells. The unique characteristics of hUCB-MNCs endow them with distinctive multifunctionality, including the promotion of angiogenesis, acceleration of tissue repair, regulation of immune responses, neuroprotection, alleviation of inflammatory reactions, enhancement of antioxidant capacity, reduction of fibrosis processes, and inhibition of apoptosis. These diverse biological properties underscore the significant clinical therapeutic potential of hUCB-MNCs, which are widely applied in the treatment of various diseases. This review aims to summarize the underlying mechanisms responsible for the multifunctional attributes of hUCB-MNCs, elucidating their potential modes of action in disease management and providing novel theoretical insights and practical guidance for their expanded application across different disease domains. By synthesizing current research findings, this review may provide insights into the potential clinical applications of hUCB-MNCs in the fields of regenerative medicine and cell therapy. |
| format | Article |
| id | doaj-art-b3ea5ce1873e4b4eb34d863cc0bad583 |
| institution | DOAJ |
| issn | 2352-3204 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Regenerative Therapy |
| spelling | doaj-art-b3ea5ce1873e4b4eb34d863cc0bad5832025-08-20T02:46:51ZengElsevierRegenerative Therapy2352-32042025-03-012810111410.1016/j.reth.2024.11.019Functional characterization and therapeutic potential of human umbilical cord blood mononuclear cellsYu Zhang0Yueda Lu1Xinyue Hu2Mengxing Jiang3Zhixiu Chen4Lingkun Jin5Min Li6Chen Chen7Jianye Wang8Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; The First Clinical College of Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, No 81 Meishan Road, Hefei 230032, Anhui, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; The First Clinical College of Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, No 81 Meishan Road, Hefei 230032, Anhui, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; The First Clinical College of Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, No 81 Meishan Road, Hefei 230032, Anhui, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; The First Clinical College of Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, No 81 Meishan Road, Hefei 230032, Anhui, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; The First Clinical College of Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, No 81 Meishan Road, Hefei 230032, Anhui, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; The First Clinical College of Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, No 81 Meishan Road, Hefei 230032, Anhui, ChinaDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; The First Clinical College of Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, No 81 Meishan Road, Hefei 230032, Anhui, China; Corresponding author. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China.Department of Surgical Oncology, Anhui Provincial Children's Hospital, No.39 East Wangjiang Road, Hefei 230022, Anhui, China; Corresponding author. Department of surgical oncology, Anhui provincial children’s hospital, No 39 Wangjiang Road, Hefei 230022, Anhui, China.Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; The First Clinical College of Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Engineering Research Center of Biopreservation and Artificial Organs, Ministry of Education, No 81 Meishan Road, Hefei 230032, Anhui, China; Corresponding author. Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China.Human umbilical cord blood mononuclear cells (hUCB-MNCs) are a population of cells derived from neonatal cord blood, encompassing various stem cells and immune cells. The unique characteristics of hUCB-MNCs endow them with distinctive multifunctionality, including the promotion of angiogenesis, acceleration of tissue repair, regulation of immune responses, neuroprotection, alleviation of inflammatory reactions, enhancement of antioxidant capacity, reduction of fibrosis processes, and inhibition of apoptosis. These diverse biological properties underscore the significant clinical therapeutic potential of hUCB-MNCs, which are widely applied in the treatment of various diseases. This review aims to summarize the underlying mechanisms responsible for the multifunctional attributes of hUCB-MNCs, elucidating their potential modes of action in disease management and providing novel theoretical insights and practical guidance for their expanded application across different disease domains. By synthesizing current research findings, this review may provide insights into the potential clinical applications of hUCB-MNCs in the fields of regenerative medicine and cell therapy.http://www.sciencedirect.com/science/article/pii/S2352320424002116Human umbilical cord blood mononuclear cellsRegenerative medicineCell therapy |
| spellingShingle | Yu Zhang Yueda Lu Xinyue Hu Mengxing Jiang Zhixiu Chen Lingkun Jin Min Li Chen Chen Jianye Wang Functional characterization and therapeutic potential of human umbilical cord blood mononuclear cells Regenerative Therapy Human umbilical cord blood mononuclear cells Regenerative medicine Cell therapy |
| title | Functional characterization and therapeutic potential of human umbilical cord blood mononuclear cells |
| title_full | Functional characterization and therapeutic potential of human umbilical cord blood mononuclear cells |
| title_fullStr | Functional characterization and therapeutic potential of human umbilical cord blood mononuclear cells |
| title_full_unstemmed | Functional characterization and therapeutic potential of human umbilical cord blood mononuclear cells |
| title_short | Functional characterization and therapeutic potential of human umbilical cord blood mononuclear cells |
| title_sort | functional characterization and therapeutic potential of human umbilical cord blood mononuclear cells |
| topic | Human umbilical cord blood mononuclear cells Regenerative medicine Cell therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2352320424002116 |
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