Association of eNOS T786C genetic polymorphism with the risk of aneurysmal subarachnoid haemorrhage
Unruptured intracranial aneurysms (IAs) are increasingly detected due to advancements in neuroimaging. Despite improvements in treatment, aneurysmal subarachnoid haemorrhage (aSAH) is associated with high mortality and morbidity. Treatment decisions for IA are complex and individualized, considering...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-04-01
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| Series: | Translational Neuroscience |
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| Online Access: | https://doi.org/10.1515/tnsci-2025-0368 |
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| author | Ljevak Josip Jerčić Kristina Gotovac Blažeković Antonela Ozretić David Perić Ivan Blažević Nikola Borovečki Fran Skurić Zdravka Poljaković |
| author_facet | Ljevak Josip Jerčić Kristina Gotovac Blažeković Antonela Ozretić David Perić Ivan Blažević Nikola Borovečki Fran Skurić Zdravka Poljaković |
| author_sort | Ljevak Josip |
| collection | DOAJ |
| description | Unruptured intracranial aneurysms (IAs) are increasingly detected due to advancements in neuroimaging. Despite improvements in treatment, aneurysmal subarachnoid haemorrhage (aSAH) is associated with high mortality and morbidity. Treatment decisions for IA are complex and individualized, considering aneurysm and patient-related risk factors. Genetic factors, particularly endothelial nitric oxide synthase (eNOS) polymorphisms, have been implicated in IA formation and rupture risk. |
| format | Article |
| id | doaj-art-b3e8f31a62354b1d84978c4504aee385 |
| institution | OA Journals |
| issn | 2081-6936 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Neuroscience |
| spelling | doaj-art-b3e8f31a62354b1d84978c4504aee3852025-08-20T02:27:09ZengDe GruyterTranslational Neuroscience2081-69362025-04-011612192710.1515/tnsci-2025-0368Association of eNOS T786C genetic polymorphism with the risk of aneurysmal subarachnoid haemorrhageLjevak Josip0Jerčić Kristina Gotovac1Blažeković Antonela2Ozretić David3Perić Ivan4Blažević Nikola5Borovečki Fran6Skurić Zdravka Poljaković7Department of Neurology, University Hospital Center Zagreb, 10 000, Zagreb, CroatiaDepartment for Personalized Medicine, University Hospital Center Zagreb, 10 000, Zagreb, CroatiaDepartment for Anatomy and Clinical Anatomy, University of Zagreb School of Medicine, 10 000, Zagreb, CroatiaDepartment of Neuroradiology, University Hospital Center Zagreb, University of Zagreb School of Medicine, 10 000, Zagreb, CroatiaDepartment of Neurology, University Hospital Center Zagreb, 10 000, Zagreb, CroatiaDepartment of Neurology, University Hospital Center Zagreb, 10 000, Zagreb, CroatiaDepartment of Neurology, University Hospital Center Zagreb, 10 000, Zagreb, CroatiaDepartment of Neurology, University Hospital Center Zagreb, 10 000, Zagreb, CroatiaUnruptured intracranial aneurysms (IAs) are increasingly detected due to advancements in neuroimaging. Despite improvements in treatment, aneurysmal subarachnoid haemorrhage (aSAH) is associated with high mortality and morbidity. Treatment decisions for IA are complex and individualized, considering aneurysm and patient-related risk factors. Genetic factors, particularly endothelial nitric oxide synthase (eNOS) polymorphisms, have been implicated in IA formation and rupture risk.https://doi.org/10.1515/tnsci-2025-0368aneurysmsubarachnoid haemorrhageenospolymorphism |
| spellingShingle | Ljevak Josip Jerčić Kristina Gotovac Blažeković Antonela Ozretić David Perić Ivan Blažević Nikola Borovečki Fran Skurić Zdravka Poljaković Association of eNOS T786C genetic polymorphism with the risk of aneurysmal subarachnoid haemorrhage Translational Neuroscience aneurysm subarachnoid haemorrhage enos polymorphism |
| title | Association of eNOS T786C genetic polymorphism with the risk of aneurysmal subarachnoid haemorrhage |
| title_full | Association of eNOS T786C genetic polymorphism with the risk of aneurysmal subarachnoid haemorrhage |
| title_fullStr | Association of eNOS T786C genetic polymorphism with the risk of aneurysmal subarachnoid haemorrhage |
| title_full_unstemmed | Association of eNOS T786C genetic polymorphism with the risk of aneurysmal subarachnoid haemorrhage |
| title_short | Association of eNOS T786C genetic polymorphism with the risk of aneurysmal subarachnoid haemorrhage |
| title_sort | association of enos t786c genetic polymorphism with the risk of aneurysmal subarachnoid haemorrhage |
| topic | aneurysm subarachnoid haemorrhage enos polymorphism |
| url | https://doi.org/10.1515/tnsci-2025-0368 |
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