Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities
Toll-like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial components. Triggering TLRs results in increased expression of multiple inflammatory genes, which then play a protective role against infection. However, aberrant activation of TLR signaling has a significant...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/781235 |
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| _version_ | 1832562159606824960 |
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| author | Jiankun Zhu Chandra Mohan |
| author_facet | Jiankun Zhu Chandra Mohan |
| author_sort | Jiankun Zhu |
| collection | DOAJ |
| description | Toll-like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial components. Triggering TLRs results in increased expression of multiple inflammatory genes, which then play a protective role against infection. However, aberrant activation of TLR signaling has a significant impact on the onset of cancer, allergy, sepsis and autoimmunity. Various adaptor proteins, including MyD88, IRAKs, TIRAP, TRIF, and TRAM, are involved in specific TLR signaling pathways. This article reviews the role of these molecules in TLR signaling, and discusses the impact of this pathway on various disease scenarios. Given their important role in infectious and non-infectious disease settings, TLRs and their signaling pathways emerge as attractive targets for therapeutics. |
| format | Article |
| id | doaj-art-b3e842b6b14b434fa00199c467af46ed |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-b3e842b6b14b434fa00199c467af46ed2025-02-03T01:23:17ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/781235781235Toll-Like Receptor Signaling Pathways—Therapeutic OpportunitiesJiankun Zhu0Chandra Mohan1The Department of Internal Medicine (Rheumatology), University of Texas Southwestern Medical School, Dallas, TX 75390, USAThe Department of Internal Medicine (Rheumatology), University of Texas Southwestern Medical School, Dallas, TX 75390, USAToll-like receptors (TLRs) are transmembrane proteins acting mainly as sensors of microbial components. Triggering TLRs results in increased expression of multiple inflammatory genes, which then play a protective role against infection. However, aberrant activation of TLR signaling has a significant impact on the onset of cancer, allergy, sepsis and autoimmunity. Various adaptor proteins, including MyD88, IRAKs, TIRAP, TRIF, and TRAM, are involved in specific TLR signaling pathways. This article reviews the role of these molecules in TLR signaling, and discusses the impact of this pathway on various disease scenarios. Given their important role in infectious and non-infectious disease settings, TLRs and their signaling pathways emerge as attractive targets for therapeutics.http://dx.doi.org/10.1155/2010/781235 |
| spellingShingle | Jiankun Zhu Chandra Mohan Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities Mediators of Inflammation |
| title | Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities |
| title_full | Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities |
| title_fullStr | Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities |
| title_full_unstemmed | Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities |
| title_short | Toll-Like Receptor Signaling Pathways—Therapeutic Opportunities |
| title_sort | toll like receptor signaling pathways therapeutic opportunities |
| url | http://dx.doi.org/10.1155/2010/781235 |
| work_keys_str_mv | AT jiankunzhu tolllikereceptorsignalingpathwaystherapeuticopportunities AT chandramohan tolllikereceptorsignalingpathwaystherapeuticopportunities |