Evaluation of proton and carbon ion beam models in TReatment Planning for Particles 4D (TRiP4D) referring to a commercial treatment planning system
Purpose: To investigate the accuracy of the treatment planning system (TPS) TRiP4D in reproducing doses computed by the clinically used TPS SyngoRT. Methods: Proton and carbon ion beam models in TRiP4D were converted from SyngoRT. Cubic plans with different depths in a water-tank phantom (WP) and pr...
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Elsevier
2025-05-01
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| Series: | Zeitschrift für Medizinische Physik |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S093938892300079X |
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| author | Yinxiangzi Sheng Lennart Volz Weiwei Wang Marco Durante Christian Graeff |
| author_facet | Yinxiangzi Sheng Lennart Volz Weiwei Wang Marco Durante Christian Graeff |
| author_sort | Yinxiangzi Sheng |
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| description | Purpose: To investigate the accuracy of the treatment planning system (TPS) TRiP4D in reproducing doses computed by the clinically used TPS SyngoRT. Methods: Proton and carbon ion beam models in TRiP4D were converted from SyngoRT. Cubic plans with different depths in a water-tank phantom (WP) and previously treated and experimentally verified patient plans from SyngoRT were recalculated in TRiP4D. The target mean dose deviation (ΔDmean,T) and global gamma index (2%–2 mm for the absorbed dose and 3%–3mm for the RBE-weighted dose with 10% threshold) were evaluated. Results: The carbon and proton absorbed dose gamma passing rates (γ-PRs) were ≥99.93% and ΔDmean,T smaller than −0.22%. On average, the RBE-weighted dose Dmean,T was −1.26% lower for TRiP4D than SyngoRT for cubic plans. In TRiP4D, the faster analytical ‘low dose approximation’ (Krämer, 2006) was used, while SyngoRT used a stochastic implementation (Krämer, 2000). The average ΔDmean, T could be reduced to −0.59% when applying the same biological effect calculation algorithm. However, the dose recalculation time increased by a factor of 79–477. ΔDmean,T variation up to −2.27% and −2.79% was observed for carbon absorbed and RBE-weighted doses in patient plans. The γ-PRs were ≥93.92% and ≥91.83% for patient plans, except for one proton beam with a range shifter (γ-PR of 64.19%). Conclusion: The absorbed dose between TRiP4D and SyngoRT were identical for both proton and carbon ion plans in the WP. Compared to SyngoRT, TRiP4D underestimated the target RBE-weighted dose; however more efficient in RBE-weighted dose calculation. Large variation for proton beam with range shifter was observed. TRiP4D will be used to evaluate doses delivered to moving targets. Uncertainties inherent to the 4D-dose reconstruction calculation are expected to be significantly larger than the dose errors reported here. For this reason, the residual differences between TRiP4D and SyngoRT observed in this study are considered acceptable.The study was approved by the Institutional Research Board of Shanghai Proton and Heavy Ion Center (approval number SPHIC-MP-2020-04, RS). |
| format | Article |
| id | doaj-art-b3e83fcbb9e24b25b4bfef8462989741 |
| institution | OA Journals |
| issn | 0939-3889 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
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| series | Zeitschrift für Medizinische Physik |
| spelling | doaj-art-b3e83fcbb9e24b25b4bfef84629897412025-08-20T01:52:22ZengElsevierZeitschrift für Medizinische Physik0939-38892025-05-0135221822610.1016/j.zemedi.2023.06.002Evaluation of proton and carbon ion beam models in TReatment Planning for Particles 4D (TRiP4D) referring to a commercial treatment planning systemYinxiangzi Sheng0Lennart Volz1Weiwei Wang2Marco Durante3Christian Graeff4Biophysics GSI Helmholtz Center for Heavy Ion Research GmbH, Darmstadt, Germany; Department of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai, China; School of Sensing Science and Engineering, Shanghai Jiao Tong University, Shanghai, ChinaBiophysics GSI Helmholtz Center for Heavy Ion Research GmbH, Darmstadt, GermanyDepartment of Medical Physics, Shanghai Proton and Heavy Ion Center, Shanghai, ChinaBiophysics GSI Helmholtz Center for Heavy Ion Research GmbH, Darmstadt, Germany; Institute of Condensed Matter Physics, Technical University of Darmstadt, Darmstadt, Germany,Biophysics GSI Helmholtz Center for Heavy Ion Research GmbH, Darmstadt, Germany; Institute of Electrical Engineering and Information Technology, Technical University of Darmstadt, Darmstadt, Germany; Corresponding author: Christian Graeff, Biophysics GSI Helmholtz Center for Heavy Ion Research GmbH, Darmstadt, Germany.Purpose: To investigate the accuracy of the treatment planning system (TPS) TRiP4D in reproducing doses computed by the clinically used TPS SyngoRT. Methods: Proton and carbon ion beam models in TRiP4D were converted from SyngoRT. Cubic plans with different depths in a water-tank phantom (WP) and previously treated and experimentally verified patient plans from SyngoRT were recalculated in TRiP4D. The target mean dose deviation (ΔDmean,T) and global gamma index (2%–2 mm for the absorbed dose and 3%–3mm for the RBE-weighted dose with 10% threshold) were evaluated. Results: The carbon and proton absorbed dose gamma passing rates (γ-PRs) were ≥99.93% and ΔDmean,T smaller than −0.22%. On average, the RBE-weighted dose Dmean,T was −1.26% lower for TRiP4D than SyngoRT for cubic plans. In TRiP4D, the faster analytical ‘low dose approximation’ (Krämer, 2006) was used, while SyngoRT used a stochastic implementation (Krämer, 2000). The average ΔDmean, T could be reduced to −0.59% when applying the same biological effect calculation algorithm. However, the dose recalculation time increased by a factor of 79–477. ΔDmean,T variation up to −2.27% and −2.79% was observed for carbon absorbed and RBE-weighted doses in patient plans. The γ-PRs were ≥93.92% and ≥91.83% for patient plans, except for one proton beam with a range shifter (γ-PR of 64.19%). Conclusion: The absorbed dose between TRiP4D and SyngoRT were identical for both proton and carbon ion plans in the WP. Compared to SyngoRT, TRiP4D underestimated the target RBE-weighted dose; however more efficient in RBE-weighted dose calculation. Large variation for proton beam with range shifter was observed. TRiP4D will be used to evaluate doses delivered to moving targets. Uncertainties inherent to the 4D-dose reconstruction calculation are expected to be significantly larger than the dose errors reported here. For this reason, the residual differences between TRiP4D and SyngoRT observed in this study are considered acceptable.The study was approved by the Institutional Research Board of Shanghai Proton and Heavy Ion Center (approval number SPHIC-MP-2020-04, RS).http://www.sciencedirect.com/science/article/pii/S093938892300079Xparticle radiotherapytreatment planningdosimetric comparison |
| spellingShingle | Yinxiangzi Sheng Lennart Volz Weiwei Wang Marco Durante Christian Graeff Evaluation of proton and carbon ion beam models in TReatment Planning for Particles 4D (TRiP4D) referring to a commercial treatment planning system Zeitschrift für Medizinische Physik particle radiotherapy treatment planning dosimetric comparison |
| title | Evaluation of proton and carbon ion beam models in TReatment Planning for Particles 4D (TRiP4D) referring to a commercial treatment planning system |
| title_full | Evaluation of proton and carbon ion beam models in TReatment Planning for Particles 4D (TRiP4D) referring to a commercial treatment planning system |
| title_fullStr | Evaluation of proton and carbon ion beam models in TReatment Planning for Particles 4D (TRiP4D) referring to a commercial treatment planning system |
| title_full_unstemmed | Evaluation of proton and carbon ion beam models in TReatment Planning for Particles 4D (TRiP4D) referring to a commercial treatment planning system |
| title_short | Evaluation of proton and carbon ion beam models in TReatment Planning for Particles 4D (TRiP4D) referring to a commercial treatment planning system |
| title_sort | evaluation of proton and carbon ion beam models in treatment planning for particles 4d trip4d referring to a commercial treatment planning system |
| topic | particle radiotherapy treatment planning dosimetric comparison |
| url | http://www.sciencedirect.com/science/article/pii/S093938892300079X |
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