Changes in salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment: a systematic review
ABSTRACT Objective: This systematic review aimed to analyze the literature on changes in endogenous salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment of children and adolescents. Material and Methods: An electronic search was perf...
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| Language: | English |
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Dental Press Editora
2024-12-01
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| Series: | Dental Press Journal of Orthodontics |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2176-94512024000600300&lng=en&tlng=en |
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| author | Rodrigo RODRIGUES Caio Melo MESQUITA Helena Benatt do Nascimento ALVES Filipe Gontijo SILVA Walbert de Andrade VIEIRA Paula Cristiana Santos de AGUIAR Carlos FLORES-MIR Luiz Renato PARANHOS Rui Barbosa de BRITO-JÚNIOR |
| author_facet | Rodrigo RODRIGUES Caio Melo MESQUITA Helena Benatt do Nascimento ALVES Filipe Gontijo SILVA Walbert de Andrade VIEIRA Paula Cristiana Santos de AGUIAR Carlos FLORES-MIR Luiz Renato PARANHOS Rui Barbosa de BRITO-JÚNIOR |
| author_sort | Rodrigo RODRIGUES |
| collection | DOAJ |
| description | ABSTRACT Objective: This systematic review aimed to analyze the literature on changes in endogenous salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment of children and adolescents. Material and Methods: An electronic search was performed in nine databases to identify quasi-experimental studies, without restricting publication language and year. Two reviewers extracted the data and assessed the individual risk of bias using the JBI tools, and the certainty of evidence using the GRADE tool. Results: The electronic search found 7,038 records, of which 12 met the eligibility criteria and were included in the qualitative synthesis. Most studies had a low risk of bias. Biomarkers were grouped into five categories: electrolytes, enzymes, hormones, immunoglobulins, and mediators. Electrolytes showed decreased Ca2+, Pi3+ and K+ levels, and increased Na+ and Cl- levels. All enzymes (ALP, LDH, MMP8, and MMP9) increased over time. Hormones presented a decrease in leptin and some fluctuations in daily cortisol levels. Immunoglobulins (IgA, IgG, IgM, IgD, and IgE) had no significant changes, and salivary IgA showed divergent results among studies. Mediators (sRANKL, OPG, IL‐1β, and PGE2) showed fluctuations at different treatment stages, mainly after orthodontic activation. Conclusions: Based on a very low certainty level, orthodontic tooth movement had little to no effect on endogenous salivary biomarkers. |
| format | Article |
| id | doaj-art-b3e7b7c9d7724f389d83d183c61f2bb1 |
| institution | OA Journals |
| issn | 2177-6709 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Dental Press Editora |
| record_format | Article |
| series | Dental Press Journal of Orthodontics |
| spelling | doaj-art-b3e7b7c9d7724f389d83d183c61f2bb12025-08-20T01:57:59ZengDental Press EditoraDental Press Journal of Orthodontics2177-67092024-12-0129610.1590/2177-6709.29.6.e242436.oarChanges in salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment: a systematic reviewRodrigo RODRIGUEShttps://orcid.org/0000-0002-4218-2303Caio Melo MESQUITAhttps://orcid.org/0000-0002-6892-3659Helena Benatt do Nascimento ALVEShttps://orcid.org/0000-0003-3895-7871Filipe Gontijo SILVAhttps://orcid.org/0009-0000-6816-7315Walbert de Andrade VIEIRAhttps://orcid.org/0000-0001-8872-2865Paula Cristiana Santos de AGUIARhttps://orcid.org/0000-0003-3226-3916Carlos FLORES-MIRhttps://orcid.org/0000-0002-0887-9385Luiz Renato PARANHOShttps://orcid.org/0000-0002-7599-0120Rui Barbosa de BRITO-JÚNIORhttps://orcid.org/0000-0002-3484-9438ABSTRACT Objective: This systematic review aimed to analyze the literature on changes in endogenous salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment of children and adolescents. Material and Methods: An electronic search was performed in nine databases to identify quasi-experimental studies, without restricting publication language and year. Two reviewers extracted the data and assessed the individual risk of bias using the JBI tools, and the certainty of evidence using the GRADE tool. Results: The electronic search found 7,038 records, of which 12 met the eligibility criteria and were included in the qualitative synthesis. Most studies had a low risk of bias. Biomarkers were grouped into five categories: electrolytes, enzymes, hormones, immunoglobulins, and mediators. Electrolytes showed decreased Ca2+, Pi3+ and K+ levels, and increased Na+ and Cl- levels. All enzymes (ALP, LDH, MMP8, and MMP9) increased over time. Hormones presented a decrease in leptin and some fluctuations in daily cortisol levels. Immunoglobulins (IgA, IgG, IgM, IgD, and IgE) had no significant changes, and salivary IgA showed divergent results among studies. Mediators (sRANKL, OPG, IL‐1β, and PGE2) showed fluctuations at different treatment stages, mainly after orthodontic activation. Conclusions: Based on a very low certainty level, orthodontic tooth movement had little to no effect on endogenous salivary biomarkers.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2176-94512024000600300&lng=en&tlng=enOrthodonticsSalivaBiomarkers |
| spellingShingle | Rodrigo RODRIGUES Caio Melo MESQUITA Helena Benatt do Nascimento ALVES Filipe Gontijo SILVA Walbert de Andrade VIEIRA Paula Cristiana Santos de AGUIAR Carlos FLORES-MIR Luiz Renato PARANHOS Rui Barbosa de BRITO-JÚNIOR Changes in salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment: a systematic review Dental Press Journal of Orthodontics Orthodontics Saliva Biomarkers |
| title | Changes in salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment: a systematic review |
| title_full | Changes in salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment: a systematic review |
| title_fullStr | Changes in salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment: a systematic review |
| title_full_unstemmed | Changes in salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment: a systematic review |
| title_short | Changes in salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment: a systematic review |
| title_sort | changes in salivary biomarkers of pain anxiety stress and inflammation related to tooth movement during orthodontic treatment a systematic review |
| topic | Orthodontics Saliva Biomarkers |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2176-94512024000600300&lng=en&tlng=en |
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