Revealing the role of U2AF1 in splicing regulation and chimeric RNA dynamics

Revealing the role of U2AF1 in splicing regulation and chimeric RNA dynamics

Abstract U2 small nuclear ribonucleoprotein auxiliary factor 1 (U2AF1) gene is a pivotal splicing factor frequently mutated in various malignancies, including myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). U2AF1 plays a critical role in the recognition and processing of 3ʹ splice...

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Bibliographic Details
Main Authors: Sangeen Khan, Yue Tang, Yangyang Guo, Jing Feng, Hui Wu, Zhenguo Song, Chengjuan Zhang, Fujun Qin
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
U2AF1
Mutation
Splicing
Alternative splicing
Chimeric RNA, cis-SAGe
RNA-seq
Online Access:https://doi.org/10.1038/s41598-025-99865-1
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