Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders
Antimicrobial resistance has significantly increased over the last 30 years, prompting scientists to continuously look for novel, effective ways to combat drug-resistant bacteria and fungi. Due to their broad range of effectiveness, ease of synthesis, and ability to avoid resistance, antimicrobial p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Drug Discovery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fddsv.2024.1440378/full |
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| author | Lucia Falcigno Simone Braccia Rosa Bellavita Gabriella D’Auria Annarita Falanga Stefania Galdiero |
| author_facet | Lucia Falcigno Simone Braccia Rosa Bellavita Gabriella D’Auria Annarita Falanga Stefania Galdiero |
| author_sort | Lucia Falcigno |
| collection | DOAJ |
| description | Antimicrobial resistance has significantly increased over the last 30 years, prompting scientists to continuously look for novel, effective ways to combat drug-resistant bacteria and fungi. Due to their broad range of effectiveness, ease of synthesis, and ability to avoid resistance, antimicrobial peptides (AMPs) represent a potential approach. The direct investigation of metal effects on peptide activity has not received much attention. Divalent metal ions such as Zn(II), Cu(II), Ni(II), and Fe(II) do, in fact, influence some AMPs, producing an effect on their mode of action or function. Although the precise process by which metals are involved in microbial death is not well understood, this review goes into detail on several potential strategies to enhance AMPs activity through the synergy with metals. Important variables in these interactions include the individual peptide sequence, the type of metal ion, the capacity of metal to form chelates, and the softness of the ligand/metal complex. This article offers a thorough summary of the ways in which metal ions alter the structure of AMPs to boost their activity or sequester metal to impact on bacteria function. |
| format | Article |
| id | doaj-art-b3e5f1ac88fd4e3e87937f0c38d98bad |
| institution | OA Journals |
| issn | 2674-0338 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Drug Discovery |
| spelling | doaj-art-b3e5f1ac88fd4e3e87937f0c38d98bad2025-08-20T01:47:37ZengFrontiers Media S.A.Frontiers in Drug Discovery2674-03382024-10-01410.3389/fddsv.2024.14403781440378Metal-antimicrobial peptides combo: promising weapons to combat bacteria invadersLucia Falcigno0Simone Braccia1Rosa Bellavita2Gabriella D’Auria3Annarita Falanga4Stefania Galdiero5Department of Pharmacy, School of Medicine, University of Naples “Federico II”, Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples “Federico II”, Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples “Federico II”, Napoli, ItalyDepartment of Pharmacy, School of Medicine, University of Naples “Federico II”, Napoli, ItalyDepartment of Agricultural Science, University of Naples “Federico II”, Portici, ItalyDepartment of Pharmacy, School of Medicine, University of Naples “Federico II”, Napoli, ItalyAntimicrobial resistance has significantly increased over the last 30 years, prompting scientists to continuously look for novel, effective ways to combat drug-resistant bacteria and fungi. Due to their broad range of effectiveness, ease of synthesis, and ability to avoid resistance, antimicrobial peptides (AMPs) represent a potential approach. The direct investigation of metal effects on peptide activity has not received much attention. Divalent metal ions such as Zn(II), Cu(II), Ni(II), and Fe(II) do, in fact, influence some AMPs, producing an effect on their mode of action or function. Although the precise process by which metals are involved in microbial death is not well understood, this review goes into detail on several potential strategies to enhance AMPs activity through the synergy with metals. Important variables in these interactions include the individual peptide sequence, the type of metal ion, the capacity of metal to form chelates, and the softness of the ligand/metal complex. This article offers a thorough summary of the ways in which metal ions alter the structure of AMPs to boost their activity or sequester metal to impact on bacteria function.https://www.frontiersin.org/articles/10.3389/fddsv.2024.1440378/fulltransition metalantimicrobial peptidessiderophorescoordinationstructural modifications |
| spellingShingle | Lucia Falcigno Simone Braccia Rosa Bellavita Gabriella D’Auria Annarita Falanga Stefania Galdiero Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders Frontiers in Drug Discovery transition metal antimicrobial peptides siderophores coordination structural modifications |
| title | Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders |
| title_full | Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders |
| title_fullStr | Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders |
| title_full_unstemmed | Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders |
| title_short | Metal-antimicrobial peptides combo: promising weapons to combat bacteria invaders |
| title_sort | metal antimicrobial peptides combo promising weapons to combat bacteria invaders |
| topic | transition metal antimicrobial peptides siderophores coordination structural modifications |
| url | https://www.frontiersin.org/articles/10.3389/fddsv.2024.1440378/full |
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