Transient cortical beta-frequency oscillations associated with contextual novelty in high density mouse EEG
Abstract Beta-frequency oscillations (20–30 Hz) are prominent in both human and rodent electroencephalogram (EEG) recordings. Discrete epochs of beta (or Beta2) oscillations are prevalent in the hippocampus and other brain areas during exploration of novel environments. However, little is known abou...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-86008-9 |
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| author | Callum Walsh Luke Tait Maria Garcia Garrido Jonathan T. Brown Thomas Ridler |
| author_facet | Callum Walsh Luke Tait Maria Garcia Garrido Jonathan T. Brown Thomas Ridler |
| author_sort | Callum Walsh |
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| description | Abstract Beta-frequency oscillations (20–30 Hz) are prominent in both human and rodent electroencephalogram (EEG) recordings. Discrete epochs of beta (or Beta2) oscillations are prevalent in the hippocampus and other brain areas during exploration of novel environments. However, little is known about the spatial distribution and temporal relationships of beta oscillations across the cortex in response to novel contexts. To investigate this, mice fitted with 30-channel EEG-style multi-electrode arrays underwent a single recording session in a novel environment. While changes to spectral properties of cortical oscillations were minimal, there was a profound increase in the rate of beta bursts during the initial part of the recording session, when the environment was most novel. This was true across the cortex but most notable in recording channels situated above the retrosplenial cortex. Additionally, novelty was associated with greater connectivity between retrosplenial areas and the rest of the cortex, specifically in the beta frequency range. However, it was also found that the cortex in general, is highly modulated by environmental novelty. This data further suggests the retrosplenial cortex is an important hub for distinguishing environmental context and highlights the diversity of functions for beta oscillations across the brain, which can be observed using high-density EEG. |
| format | Article |
| id | doaj-art-b3e41a753b4d4665beeb83f7ddf342e2 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-b3e41a753b4d4665beeb83f7ddf342e22025-01-26T12:30:32ZengNature PortfolioScientific Reports2045-23222025-01-0115111210.1038/s41598-025-86008-9Transient cortical beta-frequency oscillations associated with contextual novelty in high density mouse EEGCallum Walsh0Luke Tait1Maria Garcia Garrido2Jonathan T. Brown3Thomas Ridler4Hatherly Laboratories, Department of Clinical and Biomedical Sciences, University of Exeter Medical School, University of ExeterCardiff University Brain Research Imaging Centre, School of Psychology, Cardiff UniversityHatherly Laboratories, Department of Clinical and Biomedical Sciences, University of Exeter Medical School, University of ExeterHatherly Laboratories, Department of Clinical and Biomedical Sciences, University of Exeter Medical School, University of ExeterHatherly Laboratories, Department of Clinical and Biomedical Sciences, University of Exeter Medical School, University of ExeterAbstract Beta-frequency oscillations (20–30 Hz) are prominent in both human and rodent electroencephalogram (EEG) recordings. Discrete epochs of beta (or Beta2) oscillations are prevalent in the hippocampus and other brain areas during exploration of novel environments. However, little is known about the spatial distribution and temporal relationships of beta oscillations across the cortex in response to novel contexts. To investigate this, mice fitted with 30-channel EEG-style multi-electrode arrays underwent a single recording session in a novel environment. While changes to spectral properties of cortical oscillations were minimal, there was a profound increase in the rate of beta bursts during the initial part of the recording session, when the environment was most novel. This was true across the cortex but most notable in recording channels situated above the retrosplenial cortex. Additionally, novelty was associated with greater connectivity between retrosplenial areas and the rest of the cortex, specifically in the beta frequency range. However, it was also found that the cortex in general, is highly modulated by environmental novelty. This data further suggests the retrosplenial cortex is an important hub for distinguishing environmental context and highlights the diversity of functions for beta oscillations across the brain, which can be observed using high-density EEG.https://doi.org/10.1038/s41598-025-86008-9Beta oscillationNoveltyRetrosplenialCortexEEG |
| spellingShingle | Callum Walsh Luke Tait Maria Garcia Garrido Jonathan T. Brown Thomas Ridler Transient cortical beta-frequency oscillations associated with contextual novelty in high density mouse EEG Scientific Reports Beta oscillation Novelty Retrosplenial Cortex EEG |
| title | Transient cortical beta-frequency oscillations associated with contextual novelty in high density mouse EEG |
| title_full | Transient cortical beta-frequency oscillations associated with contextual novelty in high density mouse EEG |
| title_fullStr | Transient cortical beta-frequency oscillations associated with contextual novelty in high density mouse EEG |
| title_full_unstemmed | Transient cortical beta-frequency oscillations associated with contextual novelty in high density mouse EEG |
| title_short | Transient cortical beta-frequency oscillations associated with contextual novelty in high density mouse EEG |
| title_sort | transient cortical beta frequency oscillations associated with contextual novelty in high density mouse eeg |
| topic | Beta oscillation Novelty Retrosplenial Cortex EEG |
| url | https://doi.org/10.1038/s41598-025-86008-9 |
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