Breast cancer cells utilize T3 to trigger proliferation through cellular Ca2+ modulation

Breast cancer cells utilize T3 to trigger proliferation through cellular Ca2+ modulation

Abstract High levels of thyroid hormones are linked to increased risk and advanced stages of breast cancer. Our previous work demonstrated that the biologically active triiodothyronine (T3) facilitates mitochondrial ATP production by upregulating Ca2+ handling proteins, thereby boosting mitochondria...

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Bibliographic Details
Main Authors: Ines Tawfik, Katharina Schlick, Julian Ostaku, Doruntina Bresilla, Sonja Gabrijelčič, Benjamin Gottschalk, Alwin Sokolowski, Ernst Malle, Katarina Kalinova, Martin Hirtl, Corina T. Madreiter-Sokolowski
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell Communication and Signaling
Subjects:
Thyroid hormones
Calcium homeostasis
Breast cancer
IP3R3
Mitochondria
Thyroid hormone receptor α
Online Access:https://doi.org/10.1186/s12964-024-01917-y
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