Pharmacokinetic, biodistribution, safety and efficacy studies of borophenylalanine (BPA) in BNCT in hepatocellular carcinoma cells and tumor-bearing mouse model

Pharmacokinetic, biodistribution, safety and efficacy studies of borophenylalanine (BPA) in BNCT in hepatocellular carcinoma cells and tumor-bearing mouse model

Abstract Boron neutron capture therapy (BNCT), using boronophenylalanine (BPA) as the main boron carrier, is a dual-targeted particle radiotherapy at the cellular level. Although BPA shows clinical promise in liver cancer, there is relatively little basic research on its effect on hepatocellular car...

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Bibliographic Details
Main Authors: Tanglong Zhang, Pengcheng Zhang, Huanyu Zhang, Zhuoya Zhang, Xiaodong Jin, Ting Zhao, Juntao Ran
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Boron neutron capture therapy
Distribution of drugs
Pharmacokinetic
BPA
Online Access:https://doi.org/10.1038/s41598-025-14885-1
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