In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases
In vivo chemical screening is a broadly applicable approach not only for dissecting genetic pathways governing hematopoiesis and hematological diseases, but also for finding critical components in those pathways that may be pharmacologically modulated. Both high-throughput chemical screening and fac...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/851674 |
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| _version_ | 1850160121734234112 |
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| author | Yiyun Zhang J.-R. Joanna Yeh |
| author_facet | Yiyun Zhang J.-R. Joanna Yeh |
| author_sort | Yiyun Zhang |
| collection | DOAJ |
| description | In vivo chemical screening is a broadly applicable approach not only for dissecting genetic pathways governing hematopoiesis and hematological diseases, but also for finding critical components in those pathways that may be pharmacologically modulated. Both high-throughput chemical screening and facile detection of blood-cell-related phenotypes are feasible in embryonic/larval zebrafish. Two recent studies utilizing phenotypic chemical screens in zebrafish have identified several compounds that promote hematopoietic stem cell formation and reverse the hematopoietic phenotypes of a leukemia oncogene, respectively. These studies illustrate efficient drug discovery processes in zebrafish and reveal novel biological roles of prostaglandin E2 in hematopoietic and leukemia stem cells. Furthermore, the compounds discovered in zebrafish screens have become promising therapeutic candidates against leukemia and included in a clinical trial for enhancing hematopoietic stem cells during hematopoietic cell transplantation. |
| format | Article |
| id | doaj-art-b3dee66fca5a4b63bc0930b04734f3f2 |
| institution | OA Journals |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-b3dee66fca5a4b63bc0930b04734f3f22025-08-20T02:23:15ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/851674851674In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological DiseasesYiyun Zhang0J.-R. Joanna Yeh1Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USACardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USAIn vivo chemical screening is a broadly applicable approach not only for dissecting genetic pathways governing hematopoiesis and hematological diseases, but also for finding critical components in those pathways that may be pharmacologically modulated. Both high-throughput chemical screening and facile detection of blood-cell-related phenotypes are feasible in embryonic/larval zebrafish. Two recent studies utilizing phenotypic chemical screens in zebrafish have identified several compounds that promote hematopoietic stem cell formation and reverse the hematopoietic phenotypes of a leukemia oncogene, respectively. These studies illustrate efficient drug discovery processes in zebrafish and reveal novel biological roles of prostaglandin E2 in hematopoietic and leukemia stem cells. Furthermore, the compounds discovered in zebrafish screens have become promising therapeutic candidates against leukemia and included in a clinical trial for enhancing hematopoietic stem cells during hematopoietic cell transplantation.http://dx.doi.org/10.1155/2012/851674 |
| spellingShingle | Yiyun Zhang J.-R. Joanna Yeh In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases Advances in Hematology |
| title | In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases |
| title_full | In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases |
| title_fullStr | In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases |
| title_full_unstemmed | In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases |
| title_short | In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases |
| title_sort | in vivo chemical screening for modulators of hematopoiesis and hematological diseases |
| url | http://dx.doi.org/10.1155/2012/851674 |
| work_keys_str_mv | AT yiyunzhang invivochemicalscreeningformodulatorsofhematopoiesisandhematologicaldiseases AT jrjoannayeh invivochemicalscreeningformodulatorsofhematopoiesisandhematologicaldiseases |