Venlafaxine-Induced Orthostatic Hypotension in a Geriatric Patient
Venlafaxine is not usually associated with risk of orthostatic hypotension. A 65-year-old US Caucasian female taking 225 mg/day of venlafaxine extended-release developed symptomatic orthostatic hypotension. The systolic and diastolic blood pressure dropped by 25 and 18 mm Hg, respectively, from supi...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2013/761567 |
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| author | Vidyashree Chikkaramanjegowda Jose de Leon |
| author_facet | Vidyashree Chikkaramanjegowda Jose de Leon |
| author_sort | Vidyashree Chikkaramanjegowda |
| collection | DOAJ |
| description | Venlafaxine is not usually associated with risk of orthostatic hypotension. A 65-year-old US Caucasian female taking 225 mg/day of venlafaxine extended-release developed symptomatic orthostatic hypotension. The systolic and diastolic blood pressure dropped by 25 and 18 mm Hg, respectively, from supine position to standing position within 3 minutes. The patient was otherwise healthy and the orthostatic hypotension resolved with venlafaxine discontinuation. This was a probable venlafaxine adverse drug reaction according to the Naranjo scale. This case contributes to the scarce literature that indicates that clinicians need to be aware that occasionally venlafaxine can induce clinically significant orthostatic hypotension, particularly in geriatric patients. Our patient did not have orthostatic hypotension when she was taking venlafaxine at 60 years of age in higher venlafaxine doses (300 mg/day) but developed this adverse drug reaction when venlafaxine was restarted at the geriatric age. This case indicates that a history of prior tolerance to venlafaxine does not guarantee tolerance after 65 years of age. If a clinician decides to use venlafaxine in geriatric patients, the clinician should warn the patient about the risk of orthostatic hypotension and consider very slow titration and low doses. |
| format | Article |
| id | doaj-art-b3de1d75789a4eb1bad6ea9e03683284 |
| institution | Kabale University |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-b3de1d75789a4eb1bad6ea9e036832842025-02-03T05:52:53ZengWileyCase Reports in Psychiatry2090-682X2090-68382013-01-01201310.1155/2013/761567761567Venlafaxine-Induced Orthostatic Hypotension in a Geriatric PatientVidyashree Chikkaramanjegowda0Jose de Leon1Department of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY 40509, USADepartment of Psychiatry, College of Medicine, University of Kentucky, Lexington, KY 40509, USAVenlafaxine is not usually associated with risk of orthostatic hypotension. A 65-year-old US Caucasian female taking 225 mg/day of venlafaxine extended-release developed symptomatic orthostatic hypotension. The systolic and diastolic blood pressure dropped by 25 and 18 mm Hg, respectively, from supine position to standing position within 3 minutes. The patient was otherwise healthy and the orthostatic hypotension resolved with venlafaxine discontinuation. This was a probable venlafaxine adverse drug reaction according to the Naranjo scale. This case contributes to the scarce literature that indicates that clinicians need to be aware that occasionally venlafaxine can induce clinically significant orthostatic hypotension, particularly in geriatric patients. Our patient did not have orthostatic hypotension when she was taking venlafaxine at 60 years of age in higher venlafaxine doses (300 mg/day) but developed this adverse drug reaction when venlafaxine was restarted at the geriatric age. This case indicates that a history of prior tolerance to venlafaxine does not guarantee tolerance after 65 years of age. If a clinician decides to use venlafaxine in geriatric patients, the clinician should warn the patient about the risk of orthostatic hypotension and consider very slow titration and low doses.http://dx.doi.org/10.1155/2013/761567 |
| spellingShingle | Vidyashree Chikkaramanjegowda Jose de Leon Venlafaxine-Induced Orthostatic Hypotension in a Geriatric Patient Case Reports in Psychiatry |
| title | Venlafaxine-Induced Orthostatic Hypotension in a Geriatric Patient |
| title_full | Venlafaxine-Induced Orthostatic Hypotension in a Geriatric Patient |
| title_fullStr | Venlafaxine-Induced Orthostatic Hypotension in a Geriatric Patient |
| title_full_unstemmed | Venlafaxine-Induced Orthostatic Hypotension in a Geriatric Patient |
| title_short | Venlafaxine-Induced Orthostatic Hypotension in a Geriatric Patient |
| title_sort | venlafaxine induced orthostatic hypotension in a geriatric patient |
| url | http://dx.doi.org/10.1155/2013/761567 |
| work_keys_str_mv | AT vidyashreechikkaramanjegowda venlafaxineinducedorthostatichypotensioninageriatricpatient AT josedeleon venlafaxineinducedorthostatichypotensioninageriatricpatient |