Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer
Mitochondria are vital organelles found within living cells and have signalling, biosynthetic, and bioenergetic functions. Mitochondria play a crucial role in metabolic reprogramming, which is a characteristic of cancer cells and allows them to ensure a steady supply of proteins, nucleotides, and li...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Biomedical Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417024000179 |
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| author | Rawan Al-Faze Hoda A. Ahmed Mohamed A. El-Atawy Hayat Zagloul Eida M. Alshammari Mariusz Jaremko Abdul-Hamid Emwas Gehan M. Nabil Demiana H. Hanna |
| author_facet | Rawan Al-Faze Hoda A. Ahmed Mohamed A. El-Atawy Hayat Zagloul Eida M. Alshammari Mariusz Jaremko Abdul-Hamid Emwas Gehan M. Nabil Demiana H. Hanna |
| author_sort | Rawan Al-Faze |
| collection | DOAJ |
| description | Mitochondria are vital organelles found within living cells and have signalling, biosynthetic, and bioenergetic functions. Mitochondria play a crucial role in metabolic reprogramming, which is a characteristic of cancer cells and allows them to ensure a steady supply of proteins, nucleotides, and lipids to enable rapid proliferation and development. Their dysregulated activities have been associated with the growth and metastasis of different kinds of human cancer, particularly ovarian carcinoma. In this review, we briefly demonstrated the modified mitochondrial function in cancer, including mutations in mitochondrial DNA (mtDNA), reactive oxygen species (ROS) production, dynamics, apoptosis of cells, autophagy, and calcium excess to maintain cancer genesis, progression, and metastasis. Furthermore, the mitochondrial dysfunction pathway for some genomic, proteomic, and metabolomics modifications in ovarian cancer has been studied. Additionally, ovarian cancer has been linked to targeted therapies and biomarkers found through various alteration processes underlying mitochondrial dysfunction, notably targeting (ROS), metabolites, rewind metabolic pathways, and chemo-resistant ovarian carcinoma cells. |
| format | Article |
| id | doaj-art-b3daa123c4264478bd6e7cc7c1cd7774 |
| institution | DOAJ |
| issn | 2319-4170 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj-art-b3daa123c4264478bd6e7cc7c1cd77742025-08-20T02:50:48ZengElsevierBiomedical Journal2319-41702025-02-0148110071410.1016/j.bj.2024.100714Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancerRawan Al-Faze0Hoda A. Ahmed1Mohamed A. El-Atawy2Hayat Zagloul3Eida M. Alshammari4Mariusz Jaremko5Abdul-Hamid Emwas6Gehan M. Nabil7Demiana H. Hanna8Department of Chemistry, Faculty of Science, Taibah University, Almadinah Almunawarah, Saudi ArabiaChemistry Department, Faculty of Science at Yanbu, Taibah University, Yanbu, Saudi Arabia; Chemistry Department, Faculty of Science, Cairo University, Giza, EgyptChemistry Department, Faculty of Science at Yanbu, Taibah University, Yanbu, Saudi Arabia; Chemistry Department, Faculty of Science, Alexandria University, Ibrahemia, Alexandria, EgyptChemistry Department, Faculty of Science at Yanbu, Taibah University, Yanbu, Saudi ArabiaDepartment of Chemistry, College of Sciences, University of Ha'il, Ha'il, Saudi ArabiaBiological and Environmental Sciences & Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi ArabiaCore Labs., King Abdullah University of Science and Technology, Thuwal, Saudi ArabiaDepartment of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi ArabiaChemistry Department, Faculty of Science, Cairo University, Giza, Egypt; Corresponding author. Chemistry Department, Faculty of Science, Cairo University, 1 Gamaa Street, 12613-Giza, Egypt.Mitochondria are vital organelles found within living cells and have signalling, biosynthetic, and bioenergetic functions. Mitochondria play a crucial role in metabolic reprogramming, which is a characteristic of cancer cells and allows them to ensure a steady supply of proteins, nucleotides, and lipids to enable rapid proliferation and development. Their dysregulated activities have been associated with the growth and metastasis of different kinds of human cancer, particularly ovarian carcinoma. In this review, we briefly demonstrated the modified mitochondrial function in cancer, including mutations in mitochondrial DNA (mtDNA), reactive oxygen species (ROS) production, dynamics, apoptosis of cells, autophagy, and calcium excess to maintain cancer genesis, progression, and metastasis. Furthermore, the mitochondrial dysfunction pathway for some genomic, proteomic, and metabolomics modifications in ovarian cancer has been studied. Additionally, ovarian cancer has been linked to targeted therapies and biomarkers found through various alteration processes underlying mitochondrial dysfunction, notably targeting (ROS), metabolites, rewind metabolic pathways, and chemo-resistant ovarian carcinoma cells.http://www.sciencedirect.com/science/article/pii/S2319417024000179MitochondriaOvarian carcinomaMitochondrial dysfunction pathwayBiomarkersTargeted therapies |
| spellingShingle | Rawan Al-Faze Hoda A. Ahmed Mohamed A. El-Atawy Hayat Zagloul Eida M. Alshammari Mariusz Jaremko Abdul-Hamid Emwas Gehan M. Nabil Demiana H. Hanna Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer Biomedical Journal Mitochondria Ovarian carcinoma Mitochondrial dysfunction pathway Biomarkers Targeted therapies |
| title | Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer |
| title_full | Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer |
| title_fullStr | Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer |
| title_full_unstemmed | Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer |
| title_short | Mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer |
| title_sort | mitochondrial dysfunction route as a possible biomarker and therapy target for human cancer |
| topic | Mitochondria Ovarian carcinoma Mitochondrial dysfunction pathway Biomarkers Targeted therapies |
| url | http://www.sciencedirect.com/science/article/pii/S2319417024000179 |
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