Point-of-care ClotPro thromboelastography to determine bleeding risk in two cats with factor XII deficiency
Case series summary Factor XII (FXII) deficiency is a rare autosomal recessive genetic disorder in cats, leading to singular prolonged activated partial thromboplastin clotting time (aPTT) without increased bleeding risk. This case series describes two cats diagnosed with FXII deficiency using the C...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-03-01
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| Series: | Journal of Feline Medicine and Surgery Open Reports |
| Online Access: | https://doi.org/10.1177/20551169251319138 |
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| author | Vera Forer Pavlos G Doulidis Verena Steiner Natali Bauer Lisa Maria Kulmer Nicole Luckschander-Zeller |
| author_facet | Vera Forer Pavlos G Doulidis Verena Steiner Natali Bauer Lisa Maria Kulmer Nicole Luckschander-Zeller |
| author_sort | Vera Forer |
| collection | DOAJ |
| description | Case series summary Factor XII (FXII) deficiency is a rare autosomal recessive genetic disorder in cats, leading to singular prolonged activated partial thromboplastin clotting time (aPTT) without increased bleeding risk. This case series describes two cats diagnosed with FXII deficiency using the ClotPro system, a point-of-care viscoelastic coagulation test. Both cats exhibited significantly prolonged aPTT and intrinsic pathway clotting time but maintained normal clot strength, as indicated by thromboelastography (TEG). FXII deficiency was confirmed through quantitative ELISA measurement. Despite prolonged clotting times, the cats did not demonstrate clinical bleeding, suggesting that FXII deficiency does not increase bleeding risk. However, larger controlled studies are necessary to further investigate the utility of TEG in cats with FXII deficiency or other coagulation disorders. Relevance and novel information This study addresses the diagnostic challenges associated with FXII deficiency, a condition that can lead to misinterpretation of coagulation results and unnecessary treatments. It highlights the application of the ClotPro system in feline medicine, providing deeper insights into coagulation dynamics and confirming that FXII deficiency does not inherently increase bleeding risk despite prolonged clotting times. |
| format | Article |
| id | doaj-art-b3da0bf260804201930529c4b24e6a34 |
| institution | DOAJ |
| issn | 2055-1169 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Feline Medicine and Surgery Open Reports |
| spelling | doaj-art-b3da0bf260804201930529c4b24e6a342025-08-20T02:50:05ZengSAGE PublishingJournal of Feline Medicine and Surgery Open Reports2055-11692025-03-011110.1177/20551169251319138Point-of-care ClotPro thromboelastography to determine bleeding risk in two cats with factor XII deficiencyVera Forer0Pavlos G Doulidis1Verena Steiner2Natali Bauer3Lisa Maria Kulmer4Nicole Luckschander-Zeller5Clinical Center for Small Animals, Division of Small Animal Internal Medicine, Department for Small Animals and Horses, University of Veterinary Medicine, Vienna, AustriaClinical Center for Small Animals, Division of Small Animal Internal Medicine, Department for Small Animals and Horses, University of Veterinary Medicine, Vienna, AustriaTierklinik Sattledt, Traunkreis VET Clinic, Upper Austria, AustriaDepartment of Veterinary Clinical Sciences, Clinical Pathology and Clinical Pathophysiology, Justus-Liebig-University Giessen, Giessen, GermanyClinical Center for Small Animals, Division of Small Animal Internal Medicine, Department for Small Animals and Horses, University of Veterinary Medicine, Vienna, AustriaClinical Center for Small Animals, Division of Small Animal Internal Medicine, Department for Small Animals and Horses, University of Veterinary Medicine, Vienna, AustriaCase series summary Factor XII (FXII) deficiency is a rare autosomal recessive genetic disorder in cats, leading to singular prolonged activated partial thromboplastin clotting time (aPTT) without increased bleeding risk. This case series describes two cats diagnosed with FXII deficiency using the ClotPro system, a point-of-care viscoelastic coagulation test. Both cats exhibited significantly prolonged aPTT and intrinsic pathway clotting time but maintained normal clot strength, as indicated by thromboelastography (TEG). FXII deficiency was confirmed through quantitative ELISA measurement. Despite prolonged clotting times, the cats did not demonstrate clinical bleeding, suggesting that FXII deficiency does not increase bleeding risk. However, larger controlled studies are necessary to further investigate the utility of TEG in cats with FXII deficiency or other coagulation disorders. Relevance and novel information This study addresses the diagnostic challenges associated with FXII deficiency, a condition that can lead to misinterpretation of coagulation results and unnecessary treatments. It highlights the application of the ClotPro system in feline medicine, providing deeper insights into coagulation dynamics and confirming that FXII deficiency does not inherently increase bleeding risk despite prolonged clotting times.https://doi.org/10.1177/20551169251319138 |
| spellingShingle | Vera Forer Pavlos G Doulidis Verena Steiner Natali Bauer Lisa Maria Kulmer Nicole Luckschander-Zeller Point-of-care ClotPro thromboelastography to determine bleeding risk in two cats with factor XII deficiency Journal of Feline Medicine and Surgery Open Reports |
| title | Point-of-care ClotPro thromboelastography to determine bleeding risk in two cats with factor XII deficiency |
| title_full | Point-of-care ClotPro thromboelastography to determine bleeding risk in two cats with factor XII deficiency |
| title_fullStr | Point-of-care ClotPro thromboelastography to determine bleeding risk in two cats with factor XII deficiency |
| title_full_unstemmed | Point-of-care ClotPro thromboelastography to determine bleeding risk in two cats with factor XII deficiency |
| title_short | Point-of-care ClotPro thromboelastography to determine bleeding risk in two cats with factor XII deficiency |
| title_sort | point of care clotpro thromboelastography to determine bleeding risk in two cats with factor xii deficiency |
| url | https://doi.org/10.1177/20551169251319138 |
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