AgRP1 modulates breeding season-dependent feeding behavior in female medaka
Feeding and reproduction are known to be closely correlated with each other, and the seasonal breeders show breeding season-dependent feeding behavior. However, most model animals do not have definite breeding seasonality, and the mechanisms for such feeding behavior remain unclear. Here, we focused...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2025-05-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/100996 |
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| author | Yurika Tagui Shingo Takeda Hiroyo Waida Shoichi Kitahara Tomoki Kimura Shinji Kanda Yoshitaka Oka Yu Hayashi Chie Umatani |
| author_facet | Yurika Tagui Shingo Takeda Hiroyo Waida Shoichi Kitahara Tomoki Kimura Shinji Kanda Yoshitaka Oka Yu Hayashi Chie Umatani |
| author_sort | Yurika Tagui |
| collection | DOAJ |
| description | Feeding and reproduction are known to be closely correlated with each other, and the seasonal breeders show breeding season-dependent feeding behavior. However, most model animals do not have definite breeding seasonality, and the mechanisms for such feeding behavior remain unclear. Here, we focused on female medaka (Oryzias latipes); they show breeding season-dependent feeding behavior, and their condition of breeding season can be experimentally controlled by day-length. We first demonstrated that, among previously reported feeding-related peptides (neuropeptides involved in feeding), agouti-related peptide 1 (agrp1) and neuropeptide y b (npyb) show higher brain expression under the breeding condition than under the non-breeding one. Combined with analysis of agrp1 knockout medaka, we obtained results to suggest that long day-induced sexually mature condition, especially ovarian estrogenic signals, increase the expressions of agrp1 in the brain, which results in increased food intake to promote reproduction. Our findings advance the understanding of neural mechanisms of feeding behavior for reproductive success. |
| format | Article |
| id | doaj-art-b3d5dfb2b8f64fd9b017a09789f44bd2 |
| institution | DOAJ |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-b3d5dfb2b8f64fd9b017a09789f44bd22025-08-20T03:12:53ZengeLife Sciences Publications LtdeLife2050-084X2025-05-011310.7554/eLife.100996AgRP1 modulates breeding season-dependent feeding behavior in female medakaYurika Tagui0Shingo Takeda1Hiroyo Waida2Shoichi Kitahara3Tomoki Kimura4Shinji Kanda5https://orcid.org/0000-0001-7556-1433Yoshitaka Oka6https://orcid.org/0000-0002-3482-3051Yu Hayashi7https://orcid.org/0000-0001-5007-4532Chie Umatani8https://orcid.org/0000-0003-3612-4374Graduate School of Science, The University of Tokyo, Tokyo, JapanGraduate School of Science, The University of Tokyo, Tokyo, JapanGraduate School of Science, The University of Tokyo, Tokyo, JapanGraduate School of Science, The University of Tokyo, Tokyo, JapanDepartment of Applied Physics, The University of Tokyo, Tokyo, JapanAtmosphere and Ocean Research Institute, The University of Tokyo, Chiba, JapanGraduate School of Science, The University of Tokyo, Tokyo, JapanGraduate School of Science, The University of Tokyo, Tokyo, JapanGraduate School of Science, The University of Tokyo, Tokyo, Japan; Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, JapanFeeding and reproduction are known to be closely correlated with each other, and the seasonal breeders show breeding season-dependent feeding behavior. However, most model animals do not have definite breeding seasonality, and the mechanisms for such feeding behavior remain unclear. Here, we focused on female medaka (Oryzias latipes); they show breeding season-dependent feeding behavior, and their condition of breeding season can be experimentally controlled by day-length. We first demonstrated that, among previously reported feeding-related peptides (neuropeptides involved in feeding), agouti-related peptide 1 (agrp1) and neuropeptide y b (npyb) show higher brain expression under the breeding condition than under the non-breeding one. Combined with analysis of agrp1 knockout medaka, we obtained results to suggest that long day-induced sexually mature condition, especially ovarian estrogenic signals, increase the expressions of agrp1 in the brain, which results in increased food intake to promote reproduction. Our findings advance the understanding of neural mechanisms of feeding behavior for reproductive success.https://elifesciences.org/articles/100996Oryzias latipesfeeding behavioragrpnpyreproduction |
| spellingShingle | Yurika Tagui Shingo Takeda Hiroyo Waida Shoichi Kitahara Tomoki Kimura Shinji Kanda Yoshitaka Oka Yu Hayashi Chie Umatani AgRP1 modulates breeding season-dependent feeding behavior in female medaka eLife Oryzias latipes feeding behavior agrp npy reproduction |
| title | AgRP1 modulates breeding season-dependent feeding behavior in female medaka |
| title_full | AgRP1 modulates breeding season-dependent feeding behavior in female medaka |
| title_fullStr | AgRP1 modulates breeding season-dependent feeding behavior in female medaka |
| title_full_unstemmed | AgRP1 modulates breeding season-dependent feeding behavior in female medaka |
| title_short | AgRP1 modulates breeding season-dependent feeding behavior in female medaka |
| title_sort | agrp1 modulates breeding season dependent feeding behavior in female medaka |
| topic | Oryzias latipes feeding behavior agrp npy reproduction |
| url | https://elifesciences.org/articles/100996 |
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