Iatrogenic tension pneumocephalus complication of osteoradionecrosis in the treatment of nasopharyngeal carcinoma. A case report and critical literature review
Nasopharyngeal carcinoma typically originates in the fossa of Rosenmüller within the mucosal epithelium directly underlying the lymphatic tissue, and commonly presents clinically with symptoms such as headache, dizziness, and rhinorrhea. In this case study, we describe a 61-year-old man diagnosed wi...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2024-05-01
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| Series: | Brazilian Journal of Oncology |
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| Online Access: | https://www.brazilianjournalofoncology.com.br/details/279/en-US/iatrogenic-tension-pneumocephalus-complication-of-osteoradionecrosis-in-the-treatment-of-nasopharyngeal-carcinoma--a-case-report-and-critical-literatu |
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| author | Isidro Miguel Martín Pérez Sebastián Eustaquio Martín Pérez Adolfo Vérgez Muñoz Nart Keituqwa Yáñez María Carmen Dolado Correa Carolina Rodríguez González Fidel Rodríguez Hernández |
| author_facet | Isidro Miguel Martín Pérez Sebastián Eustaquio Martín Pérez Adolfo Vérgez Muñoz Nart Keituqwa Yáñez María Carmen Dolado Correa Carolina Rodríguez González Fidel Rodríguez Hernández |
| author_sort | Isidro Miguel Martín Pérez |
| collection | DOAJ |
| description | Nasopharyngeal carcinoma typically originates in the fossa of Rosenmüller within the mucosal epithelium directly underlying the lymphatic tissue, and commonly presents clinically with symptoms such as headache, dizziness, and rhinorrhea. In this case study, we describe a 61-year-old man diagnosed with nasopharyngeal carcinoma who underwent radiation therapy with a total dose of 50 Gy administered at a rate of 2 Gy per day, along with chemotherapy consisting of cisplatin at a dose of 100 mg/m2. Surgical intervention was deemed unsuitable due to the size of the tumors. Five months later, the patient developed a tension pneumocephalus due to a clival fistula “corking effect,” which resulted in the infiltration of air bubbles into the brain and culminating in his death 2 weeks after admission to the intensive care unit. |
| format | Article |
| id | doaj-art-b3d3e63965554b4d9ab5d18932f4d24d |
| institution | DOAJ |
| issn | 2526-8732 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Brazilian Journal of Oncology |
| spelling | doaj-art-b3d3e63965554b4d9ab5d18932f4d24d2025-08-20T03:20:52ZengThieme Revinter Publicações Ltda.Brazilian Journal of Oncology2526-87322024-05-012010.5935/2526-8732.20240449Iatrogenic tension pneumocephalus complication of osteoradionecrosis in the treatment of nasopharyngeal carcinoma. A case report and critical literature reviewIsidro Miguel Martín Pérez0Sebastián Eustaquio Martín Pérez1Adolfo Vérgez Muñoz2Nart Keituqwa Yáñez3María Carmen Dolado Correa4Carolina Rodríguez González5Fidel Rodríguez Hernández6Universidad de La Laguna, Departamento de Farmacología y Medicina Física - Santa Cruz de Tenerife - Santa Cruz de Tenerife - SpainUniversidad de La Laguna, Departamento de Farmacología y Medicina Física - Santa Cruz de Tenerife - Santa Cruz de Tenerife - SpainHospital Universitario de Canarias, Radiation Oncology Service - Santa Cruz de Tenerife - Santa Cruz de Tenerife - SpainHospital Universitario de Canarias, Radiation Oncology Service - Santa Cruz de Tenerife - Santa Cruz de Tenerife - SpainHospital Universitario de Canarias, Radiation Oncology Service - Santa Cruz de Tenerife - Santa Cruz de Tenerife - SpainUniversidad de La Laguna, Departamento de Farmacología y Medicina Física - Santa Cruz de Tenerife - Santa Cruz de Tenerife - SpainUniversidad de La Laguna, Departamento de Farmacología y Medicina Física - Santa Cruz de Tenerife - Santa Cruz de Tenerife - SpainNasopharyngeal carcinoma typically originates in the fossa of Rosenmüller within the mucosal epithelium directly underlying the lymphatic tissue, and commonly presents clinically with symptoms such as headache, dizziness, and rhinorrhea. In this case study, we describe a 61-year-old man diagnosed with nasopharyngeal carcinoma who underwent radiation therapy with a total dose of 50 Gy administered at a rate of 2 Gy per day, along with chemotherapy consisting of cisplatin at a dose of 100 mg/m2. Surgical intervention was deemed unsuitable due to the size of the tumors. Five months later, the patient developed a tension pneumocephalus due to a clival fistula “corking effect,” which resulted in the infiltration of air bubbles into the brain and culminating in his death 2 weeks after admission to the intensive care unit.https://www.brazilianjournalofoncology.com.br/details/279/en-US/iatrogenic-tension-pneumocephalus-complication-of-osteoradionecrosis-in-the-treatment-of-nasopharyngeal-carcinoma--a-case-report-and-critical-literatunasopharyngeal carcinomaradiotherapypneumocephalusosteoradionecrosis |
| spellingShingle | Isidro Miguel Martín Pérez Sebastián Eustaquio Martín Pérez Adolfo Vérgez Muñoz Nart Keituqwa Yáñez María Carmen Dolado Correa Carolina Rodríguez González Fidel Rodríguez Hernández Iatrogenic tension pneumocephalus complication of osteoradionecrosis in the treatment of nasopharyngeal carcinoma. A case report and critical literature review Brazilian Journal of Oncology nasopharyngeal carcinoma radiotherapy pneumocephalus osteoradionecrosis |
| title | Iatrogenic tension pneumocephalus complication of osteoradionecrosis in the treatment of nasopharyngeal carcinoma. A case report and critical literature review |
| title_full | Iatrogenic tension pneumocephalus complication of osteoradionecrosis in the treatment of nasopharyngeal carcinoma. A case report and critical literature review |
| title_fullStr | Iatrogenic tension pneumocephalus complication of osteoradionecrosis in the treatment of nasopharyngeal carcinoma. A case report and critical literature review |
| title_full_unstemmed | Iatrogenic tension pneumocephalus complication of osteoradionecrosis in the treatment of nasopharyngeal carcinoma. A case report and critical literature review |
| title_short | Iatrogenic tension pneumocephalus complication of osteoradionecrosis in the treatment of nasopharyngeal carcinoma. A case report and critical literature review |
| title_sort | iatrogenic tension pneumocephalus complication of osteoradionecrosis in the treatment of nasopharyngeal carcinoma a case report and critical literature review |
| topic | nasopharyngeal carcinoma radiotherapy pneumocephalus osteoradionecrosis |
| url | https://www.brazilianjournalofoncology.com.br/details/279/en-US/iatrogenic-tension-pneumocephalus-complication-of-osteoradionecrosis-in-the-treatment-of-nasopharyngeal-carcinoma--a-case-report-and-critical-literatu |
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