Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin
Gamma radiation induces the generation of free radicals, leading to serious cellular damages in biological systems. Radioprotectors act as prophylactic agents that are administered to shield normal cells and tissues from the deleterious effects of radiation. Melatonin synergistically acts as an immu...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/621570 |
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| author | Ehsan Mihandoost Alireza Shirazi Seied Rabie Mahdavi Akbar Aliasgharzadeh |
| author_facet | Ehsan Mihandoost Alireza Shirazi Seied Rabie Mahdavi Akbar Aliasgharzadeh |
| author_sort | Ehsan Mihandoost |
| collection | DOAJ |
| description | Gamma radiation induces the generation of free radicals, leading to serious cellular damages in biological systems. Radioprotectors act as prophylactic agents that are administered to shield normal cells and tissues from the deleterious effects of radiation. Melatonin synergistically acts as an immune-stimulator and antioxidant. We investigated the possible radioprotective role of melatonin (100 mg/kg i.p.) against lethal-whole-body radiation- (10 Gy) induced sickness, body weight loss, and mortality in rats. Results of the present study suggest that exposure to lethal-whole-body radiation incurred mortality, body weight loss, and apoptosis and it also depleted the immunity and the antioxidant status of the rats. Our results show that melatonin pretreatment provides protection against radiation induced mortality, oxidative stress, and immune-suppression. The melatonin pretreated irradiated rats showed less change in body weight as compared to radiation only group. On the other hand, melatonin appeared to have another radioprotective role, suggesting that melatonin may reduce apoptosis through a caspase-3-mediated pathway by blocking caspase-3 activity. |
| format | Article |
| id | doaj-art-b3d3befcf5ec42eabdf284d36fb197b8 |
| institution | DOAJ |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-b3d3befcf5ec42eabdf284d36fb197b82025-08-20T03:20:52ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/621570621570Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of MelatoninEhsan Mihandoost0Alireza Shirazi1Seied Rabie Mahdavi2Akbar Aliasgharzadeh3Department of Medical Radiation Engineering, Science and Research Branch, Islamic Azad University, Tehran, IranDepartment of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, IranDepartment of Medical Physics, Faculty of Medicine, Iran University of Medical Sciences, Tehran, IranDepartment of Radiology and Medical Physics, Faculty of Paramedicine, Kashan University of Medical Sciences, Kashan, IranGamma radiation induces the generation of free radicals, leading to serious cellular damages in biological systems. Radioprotectors act as prophylactic agents that are administered to shield normal cells and tissues from the deleterious effects of radiation. Melatonin synergistically acts as an immune-stimulator and antioxidant. We investigated the possible radioprotective role of melatonin (100 mg/kg i.p.) against lethal-whole-body radiation- (10 Gy) induced sickness, body weight loss, and mortality in rats. Results of the present study suggest that exposure to lethal-whole-body radiation incurred mortality, body weight loss, and apoptosis and it also depleted the immunity and the antioxidant status of the rats. Our results show that melatonin pretreatment provides protection against radiation induced mortality, oxidative stress, and immune-suppression. The melatonin pretreated irradiated rats showed less change in body weight as compared to radiation only group. On the other hand, melatonin appeared to have another radioprotective role, suggesting that melatonin may reduce apoptosis through a caspase-3-mediated pathway by blocking caspase-3 activity.http://dx.doi.org/10.1155/2014/621570 |
| spellingShingle | Ehsan Mihandoost Alireza Shirazi Seied Rabie Mahdavi Akbar Aliasgharzadeh Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin The Scientific World Journal |
| title | Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin |
| title_full | Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin |
| title_fullStr | Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin |
| title_full_unstemmed | Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin |
| title_short | Consequences of Lethal-Whole-Body Gamma Radiation and Possible Ameliorative Role of Melatonin |
| title_sort | consequences of lethal whole body gamma radiation and possible ameliorative role of melatonin |
| url | http://dx.doi.org/10.1155/2014/621570 |
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