Prevalence and clinical correlates of chronic obstructive pulmonary disease in heart failure patients: a cross-sectional study in China
BackgroundDespite chronic obstructive pulmonary disease’s (COPD)'s prevalence in the general populace, its incidence in heart failure (HF) patients is understudied. This study aimed to assess COPD prevalence and clinical associations in Chinese HF patients.MethodsFrom the Chinese Heart Failure...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1477388/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832542846022844416 |
|---|---|
| author | Ailing Zhu Manman Hu Dehai Ge Xiujian Zhang Jinfeng Zhang Yangchun Wang Xin Yao Junjun Liu |
| author_facet | Ailing Zhu Manman Hu Dehai Ge Xiujian Zhang Jinfeng Zhang Yangchun Wang Xin Yao Junjun Liu |
| author_sort | Ailing Zhu |
| collection | DOAJ |
| description | BackgroundDespite chronic obstructive pulmonary disease’s (COPD)'s prevalence in the general populace, its incidence in heart failure (HF) patients is understudied. This study aimed to assess COPD prevalence and clinical associations in Chinese HF patients.MethodsFrom the Chinese Heart Failure Study, demographic and clinical details of 2008 HF patients were analyzed. Divided into 233 COPD cases and 1775 non-COPD controls, a multivariable logistic regression identified factors linked to COPD onset in HF, with thorough examination of intergroup clinical differences.ResultsThe incidence of COPD in HF individuals was 11.60% (233/2008). The COPD subgroup featured a higher ratio of individuals over 60 and males, alongside lower systolic blood pressure (SBP), body mass index (BMI), higher Charlson Comorbidity Index (CCI) scores, and increased PaCO₂ levels (p < 0.05). Type II respiratory failure and right ventricular dysfunction (RVD) were more prevalent in the COPD subgroup (p < 0.001). Binary logistic regression, after adjustments, indicated positive associations between COPD and age over 60 (OR = 3.831, 95%CI: 1.085–13.526, p = 0.037), male sex (OR = 1.587, 95%CI: 1.032–2.441, p = 0.036), higher CCI (OR = 2.214, 95%CI: 1.796–2.729, p < 0.001), elevated PaCO2 (OR = 1.035, 95%CI: 1.015–1.055, p < 0.001), and RVD (OR = 0.605, 95%CI: 0.119–3.063, p = 0.544). Inversely, higher SBP (OR = 0.990, 95%CI: 0.982–0.998, p = 0.020) and log (triglycerides) (OR = 0.183, 95%CI: 0.064–0.552, p = 0.002) were negatively correlated with COPD in HF patients.ConclusionIn a large cohort of Chinese Heart Failure (HF) patients, our study revealed a notable COPD prevalence. Key risk factors included age, sex, elevated PaCO2, CCI score, and right heart failure, while higher SBP and triglyceride levels offered protection. These insights lay groundwork for probing disease mechanisms and therapeutic approaches. |
| format | Article |
| id | doaj-art-b3d2dd296bbd44c7be6fa89a1e745b7e |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-b3d2dd296bbd44c7be6fa89a1e745b7e2025-02-03T15:17:12ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.14773881477388Prevalence and clinical correlates of chronic obstructive pulmonary disease in heart failure patients: a cross-sectional study in ChinaAiling Zhu0Manman Hu1Dehai Ge2Xiujian Zhang3Jinfeng Zhang4Yangchun Wang5Xin Yao6Junjun Liu7Nanjing Meishan Hospital, Nanjing, ChinaNanjing Meishan Hospital, Nanjing, ChinaNanjing Meishan Hospital, Nanjing, ChinaNanjing Meishan Hospital, Nanjing, ChinaNanjing Meishan Hospital, Nanjing, ChinaNanjing Meishan Hospital, Nanjing, ChinaThe First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaNanjing Meishan Hospital, Nanjing, ChinaBackgroundDespite chronic obstructive pulmonary disease’s (COPD)'s prevalence in the general populace, its incidence in heart failure (HF) patients is understudied. This study aimed to assess COPD prevalence and clinical associations in Chinese HF patients.MethodsFrom the Chinese Heart Failure Study, demographic and clinical details of 2008 HF patients were analyzed. Divided into 233 COPD cases and 1775 non-COPD controls, a multivariable logistic regression identified factors linked to COPD onset in HF, with thorough examination of intergroup clinical differences.ResultsThe incidence of COPD in HF individuals was 11.60% (233/2008). The COPD subgroup featured a higher ratio of individuals over 60 and males, alongside lower systolic blood pressure (SBP), body mass index (BMI), higher Charlson Comorbidity Index (CCI) scores, and increased PaCO₂ levels (p < 0.05). Type II respiratory failure and right ventricular dysfunction (RVD) were more prevalent in the COPD subgroup (p < 0.001). Binary logistic regression, after adjustments, indicated positive associations between COPD and age over 60 (OR = 3.831, 95%CI: 1.085–13.526, p = 0.037), male sex (OR = 1.587, 95%CI: 1.032–2.441, p = 0.036), higher CCI (OR = 2.214, 95%CI: 1.796–2.729, p < 0.001), elevated PaCO2 (OR = 1.035, 95%CI: 1.015–1.055, p < 0.001), and RVD (OR = 0.605, 95%CI: 0.119–3.063, p = 0.544). Inversely, higher SBP (OR = 0.990, 95%CI: 0.982–0.998, p = 0.020) and log (triglycerides) (OR = 0.183, 95%CI: 0.064–0.552, p = 0.002) were negatively correlated with COPD in HF patients.ConclusionIn a large cohort of Chinese Heart Failure (HF) patients, our study revealed a notable COPD prevalence. Key risk factors included age, sex, elevated PaCO2, CCI score, and right heart failure, while higher SBP and triglyceride levels offered protection. These insights lay groundwork for probing disease mechanisms and therapeutic approaches.https://www.frontiersin.org/articles/10.3389/fmed.2025.1477388/fullCOPDHFprevalenceclinical correlatesCCI scorelipid metabolism |
| spellingShingle | Ailing Zhu Manman Hu Dehai Ge Xiujian Zhang Jinfeng Zhang Yangchun Wang Xin Yao Junjun Liu Prevalence and clinical correlates of chronic obstructive pulmonary disease in heart failure patients: a cross-sectional study in China Frontiers in Medicine COPD HF prevalence clinical correlates CCI score lipid metabolism |
| title | Prevalence and clinical correlates of chronic obstructive pulmonary disease in heart failure patients: a cross-sectional study in China |
| title_full | Prevalence and clinical correlates of chronic obstructive pulmonary disease in heart failure patients: a cross-sectional study in China |
| title_fullStr | Prevalence and clinical correlates of chronic obstructive pulmonary disease in heart failure patients: a cross-sectional study in China |
| title_full_unstemmed | Prevalence and clinical correlates of chronic obstructive pulmonary disease in heart failure patients: a cross-sectional study in China |
| title_short | Prevalence and clinical correlates of chronic obstructive pulmonary disease in heart failure patients: a cross-sectional study in China |
| title_sort | prevalence and clinical correlates of chronic obstructive pulmonary disease in heart failure patients a cross sectional study in china |
| topic | COPD HF prevalence clinical correlates CCI score lipid metabolism |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1477388/full |
| work_keys_str_mv | AT ailingzhu prevalenceandclinicalcorrelatesofchronicobstructivepulmonarydiseaseinheartfailurepatientsacrosssectionalstudyinchina AT manmanhu prevalenceandclinicalcorrelatesofchronicobstructivepulmonarydiseaseinheartfailurepatientsacrosssectionalstudyinchina AT dehaige prevalenceandclinicalcorrelatesofchronicobstructivepulmonarydiseaseinheartfailurepatientsacrosssectionalstudyinchina AT xiujianzhang prevalenceandclinicalcorrelatesofchronicobstructivepulmonarydiseaseinheartfailurepatientsacrosssectionalstudyinchina AT jinfengzhang prevalenceandclinicalcorrelatesofchronicobstructivepulmonarydiseaseinheartfailurepatientsacrosssectionalstudyinchina AT yangchunwang prevalenceandclinicalcorrelatesofchronicobstructivepulmonarydiseaseinheartfailurepatientsacrosssectionalstudyinchina AT xinyao prevalenceandclinicalcorrelatesofchronicobstructivepulmonarydiseaseinheartfailurepatientsacrosssectionalstudyinchina AT junjunliu prevalenceandclinicalcorrelatesofchronicobstructivepulmonarydiseaseinheartfailurepatientsacrosssectionalstudyinchina |