Dynamic 19F-MRI of pulmonary ventilation in lung transplant recipients with and without chronic lung allograft dysfunction
Background: By the time chronic lung allograft dysfunction (CLAD), with its main phenotypes bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), is diagnosed by pulmonary function testing, irreversible damage to the lung allograft may already have occurred. Dynamic 19F-M...
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Elsevier
2025-02-01
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| Series: | JHLT Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950133424001162 |
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| author | Mary A. Neal, PhD Saskia Bos, MD, PhD Charlotte W. Holland, MRCP Kieren G. Hollingsworth Gerard Meachery, FRCP Arun Nair, MD, FRCP James L. Lordan, FRCP Andrew J. Fisher, FRCP, PhD Peter E. Thelwall, PhD |
| author_facet | Mary A. Neal, PhD Saskia Bos, MD, PhD Charlotte W. Holland, MRCP Kieren G. Hollingsworth Gerard Meachery, FRCP Arun Nair, MD, FRCP James L. Lordan, FRCP Andrew J. Fisher, FRCP, PhD Peter E. Thelwall, PhD |
| author_sort | Mary A. Neal, PhD |
| collection | DOAJ |
| description | Background: By the time chronic lung allograft dysfunction (CLAD), with its main phenotypes bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), is diagnosed by pulmonary function testing, irreversible damage to the lung allograft may already have occurred. Dynamic 19F-MRI of inhaled perfluoropropane may detect subtle changes in regional lung ventilation and provides a quantitative measure of regional lung function. We assessed feasibility of detecting regional ventilation dysfunction due to CLAD in lung transplant recipients. Methods: Dynamic 19F-MRI was performed in ten lung transplant recipients, four without CLAD and six with CLAD (5 BOS, 1 RAS). Gas wash-in and washout dynamics were assessed and regional lung clearance index (RLCI) provided a quantitative metric of regional lung ventilation. Results: BOS patients had substantially greater variation in regional ventilation compared with stable patients, with more regions of reduced ventilation, especially in the periphery. Tracer washout was homogeneous and rapid in stable patients but highly heterogeneous in CLAD. CLAD patients exhibited significant difference in RLCI between central and peripheral lung regions (p = 0.0016) and a wider interquartile range of RLCI for wash-in compared with stable patients (no CLAD 4.1, BOS 10.5, p = 0.036). FEV1 (% of baseline) negatively correlated with ventilation during wash-in, most strongly for the periphery (r = −0.844, p = 0.0021). Conclusions: Dynamic 19F-MRI identified quantifiable differences in regional ventilation in lung transplant recipients with and without CLAD and was well tolerated. Larger longitudinal studies using this approach will determine if early detection of changes in regional ventilation in lung transplant patients allows earlier CLAD detection. |
| format | Article |
| id | doaj-art-b3d1eca48bfe4574a1daa60f1cc0877f |
| institution | Kabale University |
| issn | 2950-1334 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JHLT Open |
| spelling | doaj-art-b3d1eca48bfe4574a1daa60f1cc0877f2025-02-09T05:01:53ZengElsevierJHLT Open2950-13342025-02-017100167Dynamic 19F-MRI of pulmonary ventilation in lung transplant recipients with and without chronic lung allograft dysfunctionMary A. Neal, PhD0Saskia Bos, MD, PhD1Charlotte W. Holland, MRCP2Kieren G. Hollingsworth3Gerard Meachery, FRCP4Arun Nair, MD, FRCP5James L. Lordan, FRCP6Andrew J. Fisher, FRCP, PhD7Peter E. Thelwall, PhD8Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UKTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UKNewcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UKNewcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UKInstitute of Transplantation, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UKTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UKInstitute of Transplantation, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UKTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK; Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK; Corresponding author: Andrew J Fisher, Translational and Clinical Research Institute, Newcastle University, United Kingdom.Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UKBackground: By the time chronic lung allograft dysfunction (CLAD), with its main phenotypes bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), is diagnosed by pulmonary function testing, irreversible damage to the lung allograft may already have occurred. Dynamic 19F-MRI of inhaled perfluoropropane may detect subtle changes in regional lung ventilation and provides a quantitative measure of regional lung function. We assessed feasibility of detecting regional ventilation dysfunction due to CLAD in lung transplant recipients. Methods: Dynamic 19F-MRI was performed in ten lung transplant recipients, four without CLAD and six with CLAD (5 BOS, 1 RAS). Gas wash-in and washout dynamics were assessed and regional lung clearance index (RLCI) provided a quantitative metric of regional lung ventilation. Results: BOS patients had substantially greater variation in regional ventilation compared with stable patients, with more regions of reduced ventilation, especially in the periphery. Tracer washout was homogeneous and rapid in stable patients but highly heterogeneous in CLAD. CLAD patients exhibited significant difference in RLCI between central and peripheral lung regions (p = 0.0016) and a wider interquartile range of RLCI for wash-in compared with stable patients (no CLAD 4.1, BOS 10.5, p = 0.036). FEV1 (% of baseline) negatively correlated with ventilation during wash-in, most strongly for the periphery (r = −0.844, p = 0.0021). Conclusions: Dynamic 19F-MRI identified quantifiable differences in regional ventilation in lung transplant recipients with and without CLAD and was well tolerated. Larger longitudinal studies using this approach will determine if early detection of changes in regional ventilation in lung transplant patients allows earlier CLAD detection.http://www.sciencedirect.com/science/article/pii/S2950133424001162Lung transplantationChronic lung allograft dysfunctionBronchiolitis obliterates syndromeRestrictive allograft syndromeMRI |
| spellingShingle | Mary A. Neal, PhD Saskia Bos, MD, PhD Charlotte W. Holland, MRCP Kieren G. Hollingsworth Gerard Meachery, FRCP Arun Nair, MD, FRCP James L. Lordan, FRCP Andrew J. Fisher, FRCP, PhD Peter E. Thelwall, PhD Dynamic 19F-MRI of pulmonary ventilation in lung transplant recipients with and without chronic lung allograft dysfunction JHLT Open Lung transplantation Chronic lung allograft dysfunction Bronchiolitis obliterates syndrome Restrictive allograft syndrome MRI |
| title | Dynamic 19F-MRI of pulmonary ventilation in lung transplant recipients with and without chronic lung allograft dysfunction |
| title_full | Dynamic 19F-MRI of pulmonary ventilation in lung transplant recipients with and without chronic lung allograft dysfunction |
| title_fullStr | Dynamic 19F-MRI of pulmonary ventilation in lung transplant recipients with and without chronic lung allograft dysfunction |
| title_full_unstemmed | Dynamic 19F-MRI of pulmonary ventilation in lung transplant recipients with and without chronic lung allograft dysfunction |
| title_short | Dynamic 19F-MRI of pulmonary ventilation in lung transplant recipients with and without chronic lung allograft dysfunction |
| title_sort | dynamic 19f mri of pulmonary ventilation in lung transplant recipients with and without chronic lung allograft dysfunction |
| topic | Lung transplantation Chronic lung allograft dysfunction Bronchiolitis obliterates syndrome Restrictive allograft syndrome MRI |
| url | http://www.sciencedirect.com/science/article/pii/S2950133424001162 |
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