Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with Oleogels
In the complex process of wound healing, oleogels (OG) are suitable as the primary component of dressing materials, but they cannot meet the diverse requirements at different healing stages. In this study, a new kind of carbon dots (CrCi‐CDs) prepared by carbonizing human hair, exhibits excellent he...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-03-01
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| Series: | Small Structures |
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| Online Access: | https://doi.org/10.1002/sstr.202400435 |
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| author | Xiaofeng Shi Qianli Ma Xinlin Jia Zhaofan Wu Chaohong Yu Tian Gao Wei Xu Zhaonan Sun Jingwei Zhang Huanming Xiong Yuanqing Mao |
| author_facet | Xiaofeng Shi Qianli Ma Xinlin Jia Zhaofan Wu Chaohong Yu Tian Gao Wei Xu Zhaonan Sun Jingwei Zhang Huanming Xiong Yuanqing Mao |
| author_sort | Xiaofeng Shi |
| collection | DOAJ |
| description | In the complex process of wound healing, oleogels (OG) are suitable as the primary component of dressing materials, but they cannot meet the diverse requirements at different healing stages. In this study, a new kind of carbon dots (CrCi‐CDs) prepared by carbonizing human hair, exhibits excellent hemostatic, antibacterial, anti‐inflammatory, and pro‐angiogenic properties and thus supports the various stages of wound healing effectively. Such CrCi‐CDs are incorporated into OG to produce a CrCi‐CD/OG composite material with enhanced multifunctional capabilities, significantly outperforming OG alone. Various experiments in vitro and in vivo confirm that the CrCi‐CDs/OG can rapidly achieve hemostasis at the initial stage of wound formation, subsequently inhibit bacterial proliferation and biofilm formation, improve the complex microenvironment surrounding the wound, and promote neovascularization, ultimately accelerating the wound repair. |
| format | Article |
| id | doaj-art-b3d0764d2a1a4fbf95c801bb7dc94921 |
| institution | DOAJ |
| issn | 2688-4062 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj-art-b3d0764d2a1a4fbf95c801bb7dc949212025-08-20T03:01:35ZengWiley-VCHSmall Structures2688-40622025-03-0163n/an/a10.1002/sstr.202400435Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with OleogelsXiaofeng Shi0Qianli Ma1Xinlin Jia2Zhaofan Wu3Chaohong Yu4Tian Gao5Wei Xu6Zhaonan Sun7Jingwei Zhang8Huanming Xiong9Yuanqing Mao10Shanghai Key Laboratory of Orthopaedic Implants Department of Orthopedics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. ChinaDepartment of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University 2005 Songhu Road Shanghai 200433 P. R. ChinaShanghai Key Laboratory of Orthopaedic Implants Department of Orthopedics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. ChinaDepartment of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University 2005 Songhu Road Shanghai 200433 P. R. ChinaShanghai Key Laboratory of Orthopaedic Implants Department of Orthopedics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. ChinaShanghai Key Laboratory of Orthopaedic Implants Department of Orthopedics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. ChinaDepartment of Plastic and Reconstructive Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. ChinaDepartment of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University 2005 Songhu Road Shanghai 200433 P. R. ChinaShanghai Key Laboratory of Orthopaedic Implants Department of Orthopedics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. ChinaDepartment of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Fudan University 2005 Songhu Road Shanghai 200433 P. R. ChinaShanghai Key Laboratory of Orthopaedic Implants Department of Orthopedics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road Shanghai 200011 P. R. ChinaIn the complex process of wound healing, oleogels (OG) are suitable as the primary component of dressing materials, but they cannot meet the diverse requirements at different healing stages. In this study, a new kind of carbon dots (CrCi‐CDs) prepared by carbonizing human hair, exhibits excellent hemostatic, antibacterial, anti‐inflammatory, and pro‐angiogenic properties and thus supports the various stages of wound healing effectively. Such CrCi‐CDs are incorporated into OG to produce a CrCi‐CD/OG composite material with enhanced multifunctional capabilities, significantly outperforming OG alone. Various experiments in vitro and in vivo confirm that the CrCi‐CDs/OG can rapidly achieve hemostasis at the initial stage of wound formation, subsequently inhibit bacterial proliferation and biofilm formation, improve the complex microenvironment surrounding the wound, and promote neovascularization, ultimately accelerating the wound repair.https://doi.org/10.1002/sstr.202400435carbon dotsCrinis Carbonisatushemostasisoleogelswound healing |
| spellingShingle | Xiaofeng Shi Qianli Ma Xinlin Jia Zhaofan Wu Chaohong Yu Tian Gao Wei Xu Zhaonan Sun Jingwei Zhang Huanming Xiong Yuanqing Mao Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with Oleogels Small Structures carbon dots Crinis Carbonisatus hemostasis oleogels wound healing |
| title | Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with Oleogels |
| title_full | Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with Oleogels |
| title_fullStr | Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with Oleogels |
| title_full_unstemmed | Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with Oleogels |
| title_short | Multifunctional Carbon Dots Derived from Human Hair for Fast Healing Wounds Together with Oleogels |
| title_sort | multifunctional carbon dots derived from human hair for fast healing wounds together with oleogels |
| topic | carbon dots Crinis Carbonisatus hemostasis oleogels wound healing |
| url | https://doi.org/10.1002/sstr.202400435 |
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