Development and Validation of a Radiomics Nomogram Based on Magnetic Resonance Imaging and Clinicoradiological Factors to Predict HCC TACE Refractoriness
YuHan Dong,1 Jihong Hu,2 Xuerou Meng,2 Bin Yang,3 Chao Peng,1 Wei Zhao1 1Medical Imaging Department, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 2Department of Interventional Radiology, The First Affiliated Hospital of Kunming Medical Uni...
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Dove Medical Press
2025-07-01
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| author | Dong Y Hu J Meng X Yang B Peng C Zhao W |
| author_facet | Dong Y Hu J Meng X Yang B Peng C Zhao W |
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| description | YuHan Dong,1 Jihong Hu,2 Xuerou Meng,2 Bin Yang,3 Chao Peng,1 Wei Zhao1 1Medical Imaging Department, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 2Department of Interventional Radiology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 3Medical Imaging Center, The First Hospital of Kunming, Kunming, 650051, People’s Republic of ChinaCorrespondence: Wei Zhao, Medical Imaging Department, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China, Email kyyyzhaowei@foxmail.com Chao Peng, Medical Imaging Department, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China, Email 609101429@qq.comPurpose: This study constructs a predictive model for hepatocellular carcinoma (HCC) transarterial chemoembolization (TACE) refractoriness using a machine learning (ML) algorithm and verifies the predictive performance of different algorithms.Patients and Methods: Clinical and magnetic resonance imaging (MRI) data of 131 patients (48 with TACE refractoriness) who underwent repeated TACE treatment for HCC were retrospectively collected. The training and validation cohorts comprised 104 and 27 cases, respectively, following an 8:2 ratio. Clinical imaging characteristics related to TACE refractoriness were identified through logistic regression analysis. HCC lesions on arterial phase, portal phase, delayed phase, and T2-weighted fat suppression MRI images before the first TACE were manually delineated as regions of interest. Dimension reduction was conducted using variance threshold, univariate selection, and least absolute shrinkage and selection operator methods. Relevant indices of TACE refractoriness were selected. ML algorithms, including a support vector machine, random forest, logistic regression and adaptive boosting, were used to construct the radiomics, clinical prediction, and combined models. The predictive performance of these models was evaluated using receiver operating characteristic curves. The optimal model was presented as a nomogram and verified through calibration and decision curve analyses.Results: In evaluating radiomics models for predicting TACE refractoriness in HCC, the LR-developed portal venous phase (VP) model achieved optimal single-sequence performance (training AUC: 0.896, 95% CI: 0.843– 0.941; validation: 0.853, 0.727– 0.965). Multisequence models significantly surpassed single-sequence counterparts, with the T2WI-FS+AP+VP+DP multisequence LR model demonstrating peak efficacy (training: 0.905, 0.853– 0.949; validation: 0.876, 0.773– 0.976). The integrated clinical-radiomics model demonstrated robust predictive performance, achieving a training cohort AUC of 0.955 (95% CI: 0.918– 0.984) with 0.885 accuracy, 0.921 sensitivity, and 0.864 specificity, and maintained strong validation performance (AUC=0.941, 95% CI: 0.880– 0.991).Conclusion: Multisequence clinical-radiomics model accurately predicts TACE refractoriness in hepatocellular carcinoma.Keywords: hepatocellular carcinoma, machine learning, transarterial chemoembolization, radiomics |
| format | Article |
| id | doaj-art-b3ce809dd23e4861ac7466b5a3b10b98 |
| institution | DOAJ |
| issn | 1179-1322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Dove Medical Press |
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| series | Cancer Management and Research |
| spelling | doaj-art-b3ce809dd23e4861ac7466b5a3b10b982025-08-20T02:39:48ZengDove Medical PressCancer Management and Research1179-13222025-07-01Volume 17Issue 114411455104911Development and Validation of a Radiomics Nomogram Based on Magnetic Resonance Imaging and Clinicoradiological Factors to Predict HCC TACE RefractorinessDong Y0Hu JMeng X1Yang B2Peng C3Zhao W4Department of Medical ImagingInterventional DepartmentDepartment of Medical Imaging CenterDepartment of Medical ImagingDepartment of Medical ImagingYuHan Dong,1 Jihong Hu,2 Xuerou Meng,2 Bin Yang,3 Chao Peng,1 Wei Zhao1 1Medical Imaging Department, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 2Department of Interventional Radiology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China; 3Medical Imaging Center, The First Hospital of Kunming, Kunming, 650051, People’s Republic of ChinaCorrespondence: Wei Zhao, Medical Imaging Department, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China, Email kyyyzhaowei@foxmail.com Chao Peng, Medical Imaging Department, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, People’s Republic of China, Email 609101429@qq.comPurpose: This study constructs a predictive model for hepatocellular carcinoma (HCC) transarterial chemoembolization (TACE) refractoriness using a machine learning (ML) algorithm and verifies the predictive performance of different algorithms.Patients and Methods: Clinical and magnetic resonance imaging (MRI) data of 131 patients (48 with TACE refractoriness) who underwent repeated TACE treatment for HCC were retrospectively collected. The training and validation cohorts comprised 104 and 27 cases, respectively, following an 8:2 ratio. Clinical imaging characteristics related to TACE refractoriness were identified through logistic regression analysis. HCC lesions on arterial phase, portal phase, delayed phase, and T2-weighted fat suppression MRI images before the first TACE were manually delineated as regions of interest. Dimension reduction was conducted using variance threshold, univariate selection, and least absolute shrinkage and selection operator methods. Relevant indices of TACE refractoriness were selected. ML algorithms, including a support vector machine, random forest, logistic regression and adaptive boosting, were used to construct the radiomics, clinical prediction, and combined models. The predictive performance of these models was evaluated using receiver operating characteristic curves. The optimal model was presented as a nomogram and verified through calibration and decision curve analyses.Results: In evaluating radiomics models for predicting TACE refractoriness in HCC, the LR-developed portal venous phase (VP) model achieved optimal single-sequence performance (training AUC: 0.896, 95% CI: 0.843– 0.941; validation: 0.853, 0.727– 0.965). Multisequence models significantly surpassed single-sequence counterparts, with the T2WI-FS+AP+VP+DP multisequence LR model demonstrating peak efficacy (training: 0.905, 0.853– 0.949; validation: 0.876, 0.773– 0.976). The integrated clinical-radiomics model demonstrated robust predictive performance, achieving a training cohort AUC of 0.955 (95% CI: 0.918– 0.984) with 0.885 accuracy, 0.921 sensitivity, and 0.864 specificity, and maintained strong validation performance (AUC=0.941, 95% CI: 0.880– 0.991).Conclusion: Multisequence clinical-radiomics model accurately predicts TACE refractoriness in hepatocellular carcinoma.Keywords: hepatocellular carcinoma, machine learning, transarterial chemoembolization, radiomicshttps://www.dovepress.com/development-and-validation-of-a-radiomics-nomogram-based-on-magnetic-r-peer-reviewed-fulltext-article-CMARHepatocellular carcinomaMachine LearningTransarterial chemoembolizationRadiomics |
| spellingShingle | Dong Y Hu J Meng X Yang B Peng C Zhao W Development and Validation of a Radiomics Nomogram Based on Magnetic Resonance Imaging and Clinicoradiological Factors to Predict HCC TACE Refractoriness Cancer Management and Research Hepatocellular carcinoma Machine Learning Transarterial chemoembolization Radiomics |
| title | Development and Validation of a Radiomics Nomogram Based on Magnetic Resonance Imaging and Clinicoradiological Factors to Predict HCC TACE Refractoriness |
| title_full | Development and Validation of a Radiomics Nomogram Based on Magnetic Resonance Imaging and Clinicoradiological Factors to Predict HCC TACE Refractoriness |
| title_fullStr | Development and Validation of a Radiomics Nomogram Based on Magnetic Resonance Imaging and Clinicoradiological Factors to Predict HCC TACE Refractoriness |
| title_full_unstemmed | Development and Validation of a Radiomics Nomogram Based on Magnetic Resonance Imaging and Clinicoradiological Factors to Predict HCC TACE Refractoriness |
| title_short | Development and Validation of a Radiomics Nomogram Based on Magnetic Resonance Imaging and Clinicoradiological Factors to Predict HCC TACE Refractoriness |
| title_sort | development and validation of a radiomics nomogram based on magnetic resonance imaging and clinicoradiological factors to predict hcc tace refractoriness |
| topic | Hepatocellular carcinoma Machine Learning Transarterial chemoembolization Radiomics |
| url | https://www.dovepress.com/development-and-validation-of-a-radiomics-nomogram-based-on-magnetic-r-peer-reviewed-fulltext-article-CMAR |
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