Efficacy and safety of Tongxinluo in the treatment of stroke: a systematic review and meta-analysis of randomized controlled trials
ObjectiveTo evaluates the efficacy and safety of Tongxinluo in treating stroke.MethodsPubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure and Wanfang databases were performed to search literature from 2000 to 2024. Randomized controlled trials evaluating Tongxin...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1573069/full |
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| author | Zhixin Wu Jiamei Fu Yumeng Zhou Yabin Zhou |
| author_facet | Zhixin Wu Jiamei Fu Yumeng Zhou Yabin Zhou |
| author_sort | Zhixin Wu |
| collection | DOAJ |
| description | ObjectiveTo evaluates the efficacy and safety of Tongxinluo in treating stroke.MethodsPubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure and Wanfang databases were performed to search literature from 2000 to 2024. Randomized controlled trials evaluating Tongxinluo for stroke were included. The primary outcomes were efficacy and safety. Sensitivity and subgroup analyses were conducted to assess result stability and identify sources of heterogeneity. All analyses were conducted using Review Manager 5.4 and STATA 15.1.ResultsFifty-one RCTs including 9,577 participants for analysis. Tongxinluo significantly outperformed the control group in efficacy [RR = 1.20, 95% CI (1.16, 1.25)]. Adverse event incidence between groups showed no significant difference [RR = 1.01, 95% CI (0.90, 1.12)]. Additionally, Tongxinluo significantly improved NIHSS, total cholesterol (TC), and serum hypersensitive C-reactive protein (hs-CRP) levels in stroke individuals.ConclusionTongxinluo, as an adjunctive treatment for stroke, offers superior clinical efficacy compared to conventional treatments without increasing adverse event risk. However, due to study limitations, further multicenter, large-sample RCTs are required to confirm.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/. |
| format | Article |
| id | doaj-art-b3cc847efcb04816828d86a5b69df47f |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-b3cc847efcb04816828d86a5b69df47f2025-08-20T03:51:08ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.15730691573069Efficacy and safety of Tongxinluo in the treatment of stroke: a systematic review and meta-analysis of randomized controlled trialsZhixin Wu0Jiamei Fu1Yumeng Zhou2Yabin Zhou3Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaHeilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaHeilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaThe First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaObjectiveTo evaluates the efficacy and safety of Tongxinluo in treating stroke.MethodsPubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure and Wanfang databases were performed to search literature from 2000 to 2024. Randomized controlled trials evaluating Tongxinluo for stroke were included. The primary outcomes were efficacy and safety. Sensitivity and subgroup analyses were conducted to assess result stability and identify sources of heterogeneity. All analyses were conducted using Review Manager 5.4 and STATA 15.1.ResultsFifty-one RCTs including 9,577 participants for analysis. Tongxinluo significantly outperformed the control group in efficacy [RR = 1.20, 95% CI (1.16, 1.25)]. Adverse event incidence between groups showed no significant difference [RR = 1.01, 95% CI (0.90, 1.12)]. Additionally, Tongxinluo significantly improved NIHSS, total cholesterol (TC), and serum hypersensitive C-reactive protein (hs-CRP) levels in stroke individuals.ConclusionTongxinluo, as an adjunctive treatment for stroke, offers superior clinical efficacy compared to conventional treatments without increasing adverse event risk. However, due to study limitations, further multicenter, large-sample RCTs are required to confirm.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/.https://www.frontiersin.org/articles/10.3389/fphar.2025.1573069/fulltongxinluoadjunctive treatmenttraditional Chinese medicinestrokemeta-analysis |
| spellingShingle | Zhixin Wu Jiamei Fu Yumeng Zhou Yabin Zhou Efficacy and safety of Tongxinluo in the treatment of stroke: a systematic review and meta-analysis of randomized controlled trials Frontiers in Pharmacology tongxinluo adjunctive treatment traditional Chinese medicine stroke meta-analysis |
| title | Efficacy and safety of Tongxinluo in the treatment of stroke: a systematic review and meta-analysis of randomized controlled trials |
| title_full | Efficacy and safety of Tongxinluo in the treatment of stroke: a systematic review and meta-analysis of randomized controlled trials |
| title_fullStr | Efficacy and safety of Tongxinluo in the treatment of stroke: a systematic review and meta-analysis of randomized controlled trials |
| title_full_unstemmed | Efficacy and safety of Tongxinluo in the treatment of stroke: a systematic review and meta-analysis of randomized controlled trials |
| title_short | Efficacy and safety of Tongxinluo in the treatment of stroke: a systematic review and meta-analysis of randomized controlled trials |
| title_sort | efficacy and safety of tongxinluo in the treatment of stroke a systematic review and meta analysis of randomized controlled trials |
| topic | tongxinluo adjunctive treatment traditional Chinese medicine stroke meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1573069/full |
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