A case report and literature review on a large MDM2 negative retroperitoneal/psoas muscle well-differentiated liposarcoma mimicking intramuscular myxoma
Well-differentiated liposarcoma (WDLPS) typically presents as a large soft tissue mass in the retroperitoneal region. Amplification of the MDM2 gene is considered the gold standard for pathologic diagnosis. We present a case of 22 cm large intramuscular mass, located in the psoas muscle of the retro...
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Elsevier
2025-09-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043325005278 |
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| author | Victoria Xie Guiliang Yu Amanda Wiggett Justin Rivard Miao Lu Yi Yan |
| author_facet | Victoria Xie Guiliang Yu Amanda Wiggett Justin Rivard Miao Lu Yi Yan |
| author_sort | Victoria Xie |
| collection | DOAJ |
| description | Well-differentiated liposarcoma (WDLPS) typically presents as a large soft tissue mass in the retroperitoneal region. Amplification of the MDM2 gene is considered the gold standard for pathologic diagnosis. We present a case of 22 cm large intramuscular mass, located in the psoas muscle of the retroperitoneum. No macroscopic fat was identified on imaging, and the lesion featured extensive myxoid stroma, closely mimicking an intramuscular myxoma on both radiological and histopathological evaluation from biopsy sample. Final diagnosis was however revised to MDM2-negative WDLPS.This case highlights the diagnostic challenge posed by WDLPS with extensive myxoid stroma lacking MDM2 amplification and macroscopic fat on imaging. Accurate diagnosis relies on the integration of clinical, radiologic, and pathologic data, as well as thorough sampling of the tumor. |
| format | Article |
| id | doaj-art-b3c9bdf2fe2f4ee59dc5c2a695d6a58e |
| institution | DOAJ |
| issn | 1930-0433 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj-art-b3c9bdf2fe2f4ee59dc5c2a695d6a58e2025-08-20T03:17:02ZengElsevierRadiology Case Reports1930-04332025-09-012094661466810.1016/j.radcr.2025.05.094A case report and literature review on a large MDM2 negative retroperitoneal/psoas muscle well-differentiated liposarcoma mimicking intramuscular myxomaVictoria Xie0Guiliang Yu1Amanda Wiggett2Justin Rivard3Miao Lu4Yi Yan5Rady Faculty of Health Sciences, Interdisciplinary Health Program, University of Manitoba, Winnipeg, Manitoba, CanadaDepartment of Urology, Shenzhen Baoan Hospital, The Second Affiliated Hospital of Shenzhen University, Shenzhen, ChinaDepartment of Pathology, Max Rady College of Medicine, University of Manitoba, Health Sciences Centre, Winnipeg, Manitoba, CanadaDepartment of Surgery, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, CanadaDepartment of Pathology, Max Rady College of Medicine, University of Manitoba, Health Sciences Centre, Winnipeg, Manitoba, Canada; Corresponding authors.Department of Diagnostic Radiology, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada; Corresponding authors.Well-differentiated liposarcoma (WDLPS) typically presents as a large soft tissue mass in the retroperitoneal region. Amplification of the MDM2 gene is considered the gold standard for pathologic diagnosis. We present a case of 22 cm large intramuscular mass, located in the psoas muscle of the retroperitoneum. No macroscopic fat was identified on imaging, and the lesion featured extensive myxoid stroma, closely mimicking an intramuscular myxoma on both radiological and histopathological evaluation from biopsy sample. Final diagnosis was however revised to MDM2-negative WDLPS.This case highlights the diagnostic challenge posed by WDLPS with extensive myxoid stroma lacking MDM2 amplification and macroscopic fat on imaging. Accurate diagnosis relies on the integration of clinical, radiologic, and pathologic data, as well as thorough sampling of the tumor.http://www.sciencedirect.com/science/article/pii/S1930043325005278Well-differentiated liposarcomaIntramuscular myxomaMyxoid neoplasm, Core biopsy, MDM2 gene |
| spellingShingle | Victoria Xie Guiliang Yu Amanda Wiggett Justin Rivard Miao Lu Yi Yan A case report and literature review on a large MDM2 negative retroperitoneal/psoas muscle well-differentiated liposarcoma mimicking intramuscular myxoma Radiology Case Reports Well-differentiated liposarcoma Intramuscular myxoma Myxoid neoplasm, Core biopsy, MDM2 gene |
| title | A case report and literature review on a large MDM2 negative retroperitoneal/psoas muscle well-differentiated liposarcoma mimicking intramuscular myxoma |
| title_full | A case report and literature review on a large MDM2 negative retroperitoneal/psoas muscle well-differentiated liposarcoma mimicking intramuscular myxoma |
| title_fullStr | A case report and literature review on a large MDM2 negative retroperitoneal/psoas muscle well-differentiated liposarcoma mimicking intramuscular myxoma |
| title_full_unstemmed | A case report and literature review on a large MDM2 negative retroperitoneal/psoas muscle well-differentiated liposarcoma mimicking intramuscular myxoma |
| title_short | A case report and literature review on a large MDM2 negative retroperitoneal/psoas muscle well-differentiated liposarcoma mimicking intramuscular myxoma |
| title_sort | case report and literature review on a large mdm2 negative retroperitoneal psoas muscle well differentiated liposarcoma mimicking intramuscular myxoma |
| topic | Well-differentiated liposarcoma Intramuscular myxoma Myxoid neoplasm, Core biopsy, MDM2 gene |
| url | http://www.sciencedirect.com/science/article/pii/S1930043325005278 |
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